Soy: allergenic properties of proteins and IgE cross-reactions
- Authors: Gervazieva V.B.1, Samoylikov P.V.1, Zaitsev E.M.1, Bykov A.S.2
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Affiliations:
- I. Mechnikov Research Institute of Vaccines and Sera
- The First Sechenov Moscow State Medical University
- Issue: Vol 19, No 3 (2022)
- Pages: 367-377
- Section: Reviews
- URL: https://rusalljournal.ru/raj/article/view/1558
- DOI: https://doi.org/10.36691/RJA1558
- ID: 1558
Cite item
Abstract
Since the last century, European countries began to actively use soybean seeds as food additives or for food production with 100% milk and animal proteins replaced with soy.
In Russia, soy is a relatively new agricultural crop, which recently began to be used in food production. Meanwhile, some proteins of soybeans have pronounced allergenic properties. The World Health Organization classified eight soy proteins (Gly m 1–Gly m 8) as allergens capable of causing clinically significant immunoglobulin (Ig)E-mediated sensitization in patients with allergic diseases. Moreover, most of these allergens were included in the World Health Organization nomenclature over the past 15 years. Additionally, the presence of other soybean allergens that can bind to sIgE has scientific evidence. Moreover, some soy allergens have homology in amino acid sequence and three-dimensional similarity to proteins of other plants and animals. Therefore, questions of IgE-cross-reactivity are becoming relevant.
Thus, this review aimed to analyze and summarize scientific data on the chemical structure, properties, and allergenic activity of soy and soybean proteins (soybean seeds) and their cross-reactions with proteins of animal and plant origin.
Keywords
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About the authors
Valentina B. Gervazieva
I. Mechnikov Research Institute of Vaccines and Sera
Email: vbger@mail.ru
ORCID iD: 0000-0001-5191-8709
SPIN-code: 9868-9164
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowPavel V. Samoylikov
I. Mechnikov Research Institute of Vaccines and Sera
Author for correspondence.
Email: samoilikov@mail.ru
ORCID iD: 0000-0003-3580-3199
SPIN-code: 4294-2188
Scopus Author ID: 55931760300
MD, Cand. Sci. (Med.)
Russian Federation, MoscowEvgeny M. Zaitsev
I. Mechnikov Research Institute of Vaccines and Sera
Email: pertussis@yandex.ru
ORCID iD: 0000-0002-4813-9074
SPIN-code: 5089-7661
MD, Dr. Sci. (Med.)
Russian Federation, MoscowAnatoly S. Bykov
The First Sechenov Moscow State Medical University
Email: bykov_a_s@staff.sechenov.ru
ORCID iD: 0000-0002-8099-6201
SPIN-code: 3894-1190
MD, Dr. Sci. (Med.), Professor
Russian Federation, MoscowReferences
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