Soy: allergenic properties of proteins and IgE cross-reactions

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Since the last century, European countries began to actively use soybean seeds as food additives or for food production with 100% milk and animal proteins replaced with soy.

In Russia, soy is a relatively new agricultural crop, which recently began to be used in food production. Meanwhile, some proteins of soybeans have pronounced allergenic properties. The World Health Organization classified eight soy proteins (Gly m 1–Gly m 8) as allergens capable of causing clinically significant immunoglobulin (Ig)E-mediated sensitization in patients with allergic diseases. Moreover, most of these allergens were included in the World Health Organization nomenclature over the past 15 years. Additionally, the presence of other soybean allergens that can bind to sIgE has scientific evidence. Moreover, some soy allergens have homology in amino acid sequence and three-dimensional similarity to proteins of other plants and animals. Therefore, questions of IgE-cross-reactivity are becoming relevant.

Thus, this review aimed to analyze and summarize scientific data on the chemical structure, properties, and allergenic activity of soy and soybean proteins (soybean seeds) and their cross-reactions with proteins of animal and plant origin.

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About the authors

Valentina B. Gervazieva

I. Mechnikov Research Institute of Vaccines and Sera

ORCID iD: 0000-0001-5191-8709
SPIN-code: 9868-9164

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow

Pavel V. Samoylikov

I. Mechnikov Research Institute of Vaccines and Sera

Author for correspondence.
ORCID iD: 0000-0003-3580-3199
SPIN-code: 4294-2188
Scopus Author ID: 55931760300

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

Evgeny M. Zaitsev

I. Mechnikov Research Institute of Vaccines and Sera

ORCID iD: 0000-0002-4813-9074
SPIN-code: 5089-7661

MD, Dr. Sci. (Med.)

Russian Federation, Moscow

Anatoly S. Bykov

The First Sechenov Moscow State Medical University

ORCID iD: 0000-0002-8099-6201
SPIN-code: 3894-1190

MD, Dr. Sci. (Med.), Professor

Russian Federation, Moscow


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