Soy: allergenic properties of proteins and IgE cross-reactions



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Abstract

Since the last century, European countries began to actively use soybean seeds as food additives or for the production of food products with 100% replacement of milk and animal proteins with soy. In Russia, soy is a relatively new agricultural crop, which recently began to be used in food production. Meanwhile, it is known that some proteins of soybeans have the pronounced allergenic properties. 8 soy proteins (Gly m 1 - Gly m 8) are classified by the World Health Organization as allergens capable of causing clinically significant IgE-mediated sensitization in patients with allergic diseases. Moreover, most of these allergens have been included in the WHO nomenclature over the past 15 years. In addition, there is scientific evidence for the presence of other soybean allergens that can bind to sIgE. It has also been shown that some soy allergens have homology in amino acid sequence and three-dimensional similarity to proteins of other plants and animals. In this regard, questions of IgE - cross-reactivity are becoming relevant. In this way, the purpose of this review is to analyze and summarize scientific data on the chemical structure, properties, allergenic activity of soy and soybean proteins (soybean seeds), their cross-reactions with proteins of animal and plant origin.

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Competing interests

The authors declare no potential and apparent conflicts of interest associated with the publication of this manuscript.

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There was no external funding for the article preparation.

Author contribution.

All authors made a significant contribution to the preparation and writing of the manuscript, in accordance with the international ICMJE authorship criteria.

The largest contribution is distributed as follows:

Gervazieva V.B. – selection of the topic and concept of the review article, collection and analysis of literary sources, editing the text of the article.

Samoylikov P.V., Zaitsev E.M., Bykov A.S. – collection and analysis of literature data, as well as editing, preparation and writing of the text of the article.

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About the authors

Valentina Borisovna Gervazieva

I. Mechnikov Research Institute of Vaccines and Sera

Email: vbger@mail.ru

 professor, honored scientist of the Russian Federation, head of the laboratory of allergodiagnostics.

Moscow, Russia, 5a, Malyi Kazennyi lane

Pavel Vladimirovich Samoylikov

I. Mechnikov Research Institute of Vaccines and Sera

Author for correspondence.
Email: samoilikov@mail.ru
ORCID iD: 0000-0003-3580-3199
SPIN-code: 4294-2188
Scopus Author ID: 55931760300

Ph.D., senior scientist, laboratory of allergodiagnostics

Russian Federation, Moscow, Russia, 5a, Malyi Kazennyi lane

Evgeny Michailovich Zaitsev

I. Mechnikov Research Institute of Vaccines and Sera

Email: pertussis@yandex.ru
ORCID iD: 0000-0002-4813-9074

Ph.D., head of laboratory of immunomodulators

Russian Federation, Moscow, Russia, 5a, Malyi Kazennyi lane

Anatoly Sergeevich Bykov

The State Education Institution of Higher Professional Training The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation

Email: bykov_a_s@staff.sechenov.ru
ORCID iD: 0000-0002-8099-6201

Professor at the Department of Microbiology, Virology and Immunology, medical and preventive faculty

Russian Federation, Moscow, Russia, 8-2, Trubetskaya street

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