Active tolerance development in allergy to cow-based milk proteins
- Authors: Galimova A.A.1, Vyazankina S.S.1, Makarova S.G.1,2, Ereshko O.A.1
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Affiliations:
- National Medical Research Center for Children’s Health
- Lomonosov Moscow State University
- Issue: Vol 18, No 4 (2021)
- Pages: 116-125
- Section: Reviews
- URL: https://rusalljournal.ru/raj/article/view/1491
- DOI: https://doi.org/10.36691/RJA1491
- ID: 1491
Cite item
Abstract
Food allergy is a potentially life-threatening condition without approved pathogenetic treatments other than eliminating the causal allergen and relief of acute allergic conditions. Immunoglobulin G-mediated form of food allergy remains a serious and growing problem worldwide. Its prevalence is steadily increasing and is a severe psychosocial and economic burden for patients and their families. Cow-based milk and products are important components of a child’s diet, which are introduced at their first year of life, which can cause allergic reactions. The traditional management of children with cow-based milk allergy includes eliminating the dairy-free diet, and a significant number of patients form milk protein tolerance by the age of 5 years. However, with persistent forms of allergy to cow-based milk proteins, the need for “active” tactics of patient management to form tolerance arises. Oral immunotherapy is a promising approach to food allergy treatments based on a gradually increased allergen by analogy with standardized immunotherapy for respiratory allergens until reaching a maintenance dose. Each stage of oral immunotherapy should be considered as a personalized therapy.
This review contains an analysis of available studies on the effectiveness of oral immunotherapy in the treatment of cow-based milk protein allergy.
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About the authors
Albina A. Galimova
National Medical Research Center for Children’s Health
Author for correspondence.
Email: albina86@yandex.ru
ORCID iD: 0000-0002-6701-3872
SPIN-code: 2960-6185
MD, Junior Research Associate
Russian Federation, 2 b. 1, Lomonosovsky prospekt, Moscow, 119991Svetlana S. Vyazankina
National Medical Research Center for Children’s Health
Email: svsvpav@mail.ru
ORCID iD: 0000-0002-6945-1104
SPIN-code: 5222-7651
MD
Russian Federation, 2 b. 1, Lomonosovsky prospekt, Moscow, 119991Svetlana G. Makarova
National Medical Research Center for Children’s Health; Lomonosov Moscow State University
Email: sm27@yandex.ru
ORCID iD: 0000-0002-3056-403X
SPIN-code: 2094-2840
MD, Dr. Sci. (Med.), Professor
Russian Federation, 2 b. 1, Lomonosovsky prospekt, Moscow, 119991; MoscowOksana A. Ereshko
National Medical Research Center for Children’s Health
Email: ksenya2005@inbox.ru
ORCID iD: 0000-0002-1650-652X
SPIN-code: 3893-9946
MD, Cand. Sci. (Med.)
Russian Federation, 2 b. 1, Lomonosovsky prospekt, Moscow, 119991References
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