Anaphylaxis in infants

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Abstract


Anaphylaxis is defined as a serious generalized allergic or hypersensitivity reaction that is rapid in onset and might cause death. Number of patients with anaphylaxis is increased over the last years in all age groups. However, data of anaphylaxis in infants is limited. The knowledge of anaphylaxis in this group of patients is based only on the description of clinical case-report, a retrospective analysis of registers for severe allergic reactions of emergency treatment units. However, children of the first years of life are extremely vulnerable and they have clinical features of the development of anaphylaxis. This article summarizes information on various aspects of anaphylaxis in infants.

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N V Esakova

Academician Yu.E. Veltishchev Research Clinical Institute of Pediatrics N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation

Email: env007@rambler.ru

N G Konjukova

Academician Yu.E. Veltishchev Research Clinical Institute of Pediatrics N. I. Pirogov Russian National Research Medical University, Ministry of Health of the Russian Federation

  1. Portier P., Richet C. Del’action anaphylactic de certains venins. C. R. Soc Biol Paris. 1902; 54: 170-172.
  2. Пампура АН, Конюкова НГ Анафилаксия к пищевым продуктам у детей раннего возраста. Российский вестник перинатологии и педиатрии. 2011; (5): 76-84
  3. Sampson HA, Munoz-Furlong A., Campbell RL, Adkinson NF, Bock SA, Branum A. et al. Second symposium on the definition and management of anaphylaxis: summary report - Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. J. Allergy Clin Immunol. 2006; 117: 391-397. doi: 10.1016/j.jaci.2005.12.1303.
  4. Muraro A., Halken S., Arshad SH, Beyer K., Dubois AE, Du Toit G. et al. EAACI food allergy and anaphylaxis guidelines. Primary prevention of food allergy. Allergy. 2014; 69: 590-601. doi: 10.1111/all.12398.
  5. Gupta R., Sheikh A., Strachan D., Anderson HR. Increasing hospital admissions for systemic allergic disorders in England: Analysis of national admissions data. BMJ. 2003; 327: 1142-1143. doi: 10.1136/bmj.327.7424.1142.
  6. Tejedor Alonso MA, Moro MM, Hernandez JE, Mugica Garcia MV, Albelda CV, Ingelmo AR et al. Incidence of anaphylaxis in hospitalized patients. Int Arch Allergy Immunol. 2011; 156: 212-220. doi: 10.1159/000322997.
  7. Hopf Y., Watson M., Williams D. Adverse-drug-reaction related admissions to a hospital in Scotland. Pharm World Sci. 2008; 30: 854-862. doi: 10.1007/s11096-008-9240-5.
  8. Decker' WW, Campbell RL, Manivannan V., Luke A., St Sauver JL, Weaver A. et al. The etiology and incidence of anaphylaxis in Rochester, Minnesota: a report from the Rochester Epidemiology Project. J. Allergy Clin Immunol. 2008; 122(6): 1161-1165. doi: 10.1016/j.jaci.2008.09.043.
  9. Huang F., Chawla K., Järvinen KM, Nowak-Wegrzyn A. Anaphylaxis in a New York City pediatric emergency department: Triggers, treatments, and outcomes. J. Allergy Clin Immunol. 2012; 129: 162-168. doi: 10.1016/j.jaci.2011.09.018.
  10. De Silva IL, Mehr SS, Tey D., Tang ML. Paediatric anaphylaxis: A 5 year retrospective review. Allergy. 2008; 63: 1071-1076. doi: 10.1111/j.1398-9995.2008.01719.x.
  11. Topal E., Bakirtas A., Yilmaz O., Ertoy Karagol IH, Arga M., Demirsoy MS et al. Anaphylaxis in infancy compared with older children. Allergy Asthma Proc. 2013; 34: 233-238. doi: 10.2500/aap.2013.34.3658.
  12. Esakova NV, Treneva MS, Okuneva TS, Pampura AN. Food Anaphylaxis: Reported Cases in Russian Federation Children. American Journal of Public Health Research. 2015; 5: 187-191. doi: 10.12691/ajphr-3-5-2.
  13. Young MC. General treatment of anaphylaxis. In: D.Y.M. Leung, H.A. Sampson, R.S. Geha, S.J. Szefler (eds.). Pediatric allergy principles and practice. St Louis (MO): Mosby, Inc. 2003: 643-654.
  14. Simons FER., Chad ZH, Gold M. Anaphylaxis in children: real-time reporting from a national network. Allergy Clin Immunol. 2004; Suppl 1: 242-244.
  15. Mehl A., Wahn U., Niggemann B. Anaphylactic reactions in children: a questionnaire-based survey in Germany. Allergy. 2005; 60: 1440-1445. doi: 10.1111/j.1398-9995.2005.00909.x.
  16. Speakman S., Kool B., Sinclair J., Fitzharris P. Paediatric food-induced anaphylaxis hospital presentations in New Zealand. J. Paediatr Child Health. 2018; 54: 254-259. doi: 10.1111/jpc.13705.
  17. Alvarez-Perea A., Ameiro B., Morales C., Zambrano G., Rodriguez A., Guzman M. et al. Anaphylaxis in the Pediatric Emergency Department: Analysis of 133 Cases After an Allergy Workup. J. Allergy Clin Immunol Pract. 2017; 5: 1256-1263. doi: 10.1016/j.jaip.2017.02.011.
  18. Goh SH, Soh JY, Loh W., Lee KP, Tan SC, Heng WJK. et al. Cause and Clinical Presentation of Anaphylaxis in Singapore: From Infancy to Old Age. Int Arch Allergy Immunol. 2018; 175: 91-98. doi: 10.1159/000485127.
  19. Monti G., Marinaro L., Libanore V., Peltran A., Muratore MC, Silvestro L. Anaphylaxis due to fish hypersensitivity in an exclusively breastfed infant. Acta Paediatr 2006; 95: 1514-1515. doi: 10.1080/08035250600732013.
  20. Pessler F., Nejat M. Anaphylactic reaction to goat’s milk in a cow’s milk-allergic infant. Pediatr Allergy Immunol. 2004; 15: 183-185. doi: 10.1046/j.1399-3038.2003.00087.x.
  21. Ammar F., de Boissieu D., Dupont C. Allergy to protein hydrolysates. Report of 30 cases. Arch Pediatr. 1999; 6: 837-843.
  22. Cantani A., Micera M. Allergenicity of a whey hypoallergenic formula in genetically at risk babies: four case reports. Eur Rev Med Pharmacol Sci. 2005; 9: 179-182.
  23. De Swert LF, Cadot P., Ceuppens JL. Diagnosis and natural course of allergy to cooked potatoes in children. Allergy. 2007; 62: 750-757. doi: 10.1111/j.1398-9995.2007.01368.x.
  24. Dalal I., Binson I., Levine A., Somekh E., Ballin A., Reifen R. The pattern of sesame sensitivity among infants and children. Pediatr Allergy Immunol. 2003; 14: 312-316.
  25. Roberts JR, Gerstner TV, Grewar DA. Allergy to caribou and seal meats in Inuit children: a report of three cases. J. Allergy Clin Immunol. 2006; 117: S42.
  26. Tuncel T., Uysal P., Hocaoglu AB., Erge DO, Firinci F., Karaman O. et al. Anaphylaxis caused by honey ingestion in an infant. Allergol Immunopathol. 2011; 39: 112-113. doi: 10.1016/j.aller.2010.04.007.
  27. Zurzolo GA, Allen KJ, Peters RL, Tang ML et al. Anaphylaxis to packaged foods in Australasia. J. Paediatr Child Health. 2018. doi: 10.1111/jpc.13823.
  28. Xing Y., Zhang H., Sun S., Ma X., Pleasants RA, Tang H. et al. Clinical features and treatment of pediatric patients with drug-induced anaphylaxis: a study based on pharmacovigilance data. Eur J. Pediatr. 2018; 177: 145-154. doi: 10.1007/s00431-017-3048-z.
  29. Guvenir H., Dibek Misirlioglu E., Capanoglu M., Buyuktiryaki B., Onay ZR, Ginis T. et al. The Frequency of Nonsteroidal Anti-Inflammatory Drug Hypersensitivity in Children with Asthma. Int Arch Allergy Immunol. 2018. doi: 10.1159/000487305.
  30. Gabrielli S., Clarke AE, Eisman H., Morris J., Joseph L., La Vieille S. et al. Disparities in rate, triggers, and management in pediatric and adult cases of suspected drug-induced anaphylaxis in Canada. Immun Inflamm Dis. 2018; 6: 3-12. doi: 10.1002/iid3.201.
  31. Moneret-Vautrin DA, Morisset M., Cordebar V., Codreanu F., Kanny G. Probiotics may be unsafe in infants allergic to cow’s milk. Allergy. 2006; 61: 507-508. doi: 10.1111/j.1398-9995.2006.01050.x.
  32. Есакова НВ, Пампура АН, Варламов ЕЕ, Окунева Т.С. Клинико-иммунологические особенности детей с анафилаксией к рыбе. Экспериментальная и клиническая гастроэнтерология. 2017; 1: 78-82
  33. McNeil MM, Weintraub ES, Duffy J., Sukumaran L., Jacobsen SJ, Klein NP. Risk of anaphylaxis after vaccination in children and adults. J. Allergy Clin Immunol. 2016; 137: 868-878. doi: 10.1016/j.jaci.2015.07.048.
  34. Yavuz ST, Sahiner UM, Sekerel BE, Tuncer A., Kalayci O., Sackesen C. Anaphylactic reactions to measles-mumps-rubella vaccine in three children with allergies to hen’s egg and cow’s milk. Acta Paediatr. 2011; 100: 94-96. doi: 10.1111/j.1651-2227.2011.02165.x.
  35. Dreskin SC, Halsey NA, Kelso JM, Wood RA, Hummell DS, Edwards KM et al. International Consensus (ICON): allergic reactions to vaccines. World Allergy Organ J. 2016; 9: 32. doi: 10.1186/s40413-016-0120-5.
  36. Kelso JM, Jones RT, Yunginger JW Anaphylaxis to measles, mumps, and rubella vaccine mediated by IgE to gelatin. J. Allergy Clin Immunol. 1993; 91: 867-872.
  37. Lee JM, Greenes DS. Biphasic anaphylactic reactions in pediatrics. Pediatrics. 2000; 106: 762-766.
  38. Mehr S., Liew WK, Tey D., Tang ML. Clinical predictors for biphasic reactions in children presenting with anaphylaxis. Clin Exp Allergy. 2009; 39: 1390-1396. doi: 10.1111/j.1365-2222.2009.03276.x.
  39. Shadick NA, Liang MH, Partridge AJ, Bingham III CO, Wright E., Fossel AH et al. The natural history of exercise-induced anaphylaxis: survey results from a 10-year follow-up study. J. Allergy Clin Immunol. 1999; 104: 123-127.
  40. Muraro GR, Clark A., Eigenmann P., Eigenmann PA, Halken S., Lack G. et al. The management of anaphylaxis in childhood: position paper of the European academy of allergology and clinical immunology. Allergy. 2007; 62: 857871. doi: 10.1111/j.13989995.2007.01421.x.
  41. Lieberman P., Nicklas RA, Oppenheimer J., Kemp SF, Lang DM, Bernstein DI et al. The diagnosis and management of anaphylaxis practicparameter: 2010 Update. J. Allergy Clin Immunol. 2010; 126: 477-480. doi: 10.1016/j.jaci.2010.06.022.
  42. Simons FE, Sampson HA. Anaphylaxis: Unique aspects of clinical diagnosis and management in infants (birth to age 2 years). J. Allergy Clin Immunol. 2015; 5: 1125-1131. doi: 10.1016/j.jaci.2014.09.014.
  43. Dosanjh A. Infant anaphylaxis: the importance of early recognition. J. Asthma Allergy. 2013; 6: 103-107. doi: 10.2147/JAA.S42694.
  44. Sampson H. Anaphylaxis and Emergency Treatment. Pediatrics. 2003; 111: 1601-1608.
  45. Simons FE.R. Anaphylaxis, killer allergy: long-term management in the community. J. Allergy Clin Immunol. 2006; 117: 367-377. doi: 10.1016/j.jaci.2005.12.002.
  46. Buckley MG, Variend S., Walls AF. Elevated serum concentrations of beta-tryptase, but not alpha-tryptase, in Sudden Infant Death Syndrome (SIDS). An investigation of anaphylactic mechanisms. Clin Exp Allergy. 2001; 31: 1696-1704.
  47. Hagan LL, Goetz DW, Revercomb CH, Garriott J. Sudden infant death syndrome: a search for allergen hypersensitivity. Ann Allergy Asthma Immunol. 1998; 80: 227-231. doi: 10.1016/S1081-1206(10)62962-6.
  48. Kim H., Dinakar C., McInnis P., Rudin D., Benain X., Daley W. et al. Inadequacy of current pediatric epinephrine auto injector needle length for use in infants and toddlers. Ann Allergy Asthma Immunol. 2017; 118: 719-725. doi: 10.1016/j.anai.2017.03.017.
  49. Sheikh A., Broek VM, Brown SGA, Simons FER. ^-antihistamines for the treatment of anaphylaxis with and without shock. Cochrane Database Syst Rev 2007; 1: CD006160. doi: 10.1002/14651858.CD006160.pub2.
  50. Starke PR, Weaver J., Chowdhury BA. Boxed warning added to promethazine labeling for pediatric use. N. Engl J. Med. 2005; 352: 2653. doi: 10.1056/NEJM200506233522522.
  51. Simons F. Anaphylaxis: Recent advances in assessment and treatment. J. Allergy Clin Immunol. 2009; 124: 625-636. doi: 10.1016/j.jaci.2009.08.025.
  52. Ruiz-Baques A., Contreras-Porta J., Marques-Mejias M., Cardenas Rebollo JM, Capel Torres F., Arino Pla MN et al. Evaluation of an Online Educational Program for Parents and Caregivers of Children With Food Allergies. J. Investig Allergol Clin Immunol. 2018; 28: 37-41. doi: 10.18176/jiaci.0214.

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