«Possibilities of a unified approach to the treatment of IgE-associated respiratory diseases. Clinical Experience exchange».

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Abstract

Inflammatory diseases of the upper and lower respiratory airways, such as allergic rhinitis, nasal polyposis, bronchial asthma have common proinflammatory mechanisms, mediated by IgE-dependent cascade of inflammation. Concurrent existence of asthma and allergic rhinitis and/or nasal polyposis increases clinical symptoms severity, disease course aggravation and eventually disease control loss for the patient. Anti-IgE-therapy is pathogenetically justified effective and safe therapeutic option for various patient groups. Today principles of interdisciplinary approach are in practice to target upper and lower respiratory diseases management, which determines the success of biological therapy. ENT, pulmonology and allergy specialists define patient management tactics in close collaboration taking into consideration diseases manifestation. The proven efficacy and safety of оmalizumab makes this drug a universal tool to achieve IgE-associated diseases control and an alternative solution for surgical intervention and therapy with systemic corticosteroids.

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About the authors

Olga P. Ukhanova

Stavropol Regional Clinical Hospital

Author for correspondence.
Email: uhanova_1976@mail.ru
ORCID iD: 0000-0002-7247-0621
SPIN-code: 8287-2891

MD, Dr. Sci. (Med.), Professor

Russian Federation, Stavropol

Dmitrii V. Karamishev

Moscow Regional Research Clinical Institute named by M.F. Vladimirskiy

Email: d.v.karamyshev@bk.ru
ORCID iD: 0000-0002-1323-4821
SPIN-code: 9930-2075

MD

Russian Federation, Moscow

Kseniya A. Ryabova

The First Sechenov Moscow State Medical University

Email: acksinja@gmail.com
ORCID iD: 0000-0003-0520-0936
SPIN-code: 9000-6894

MD, Research Associate

Russian Federation, Moscow

Fatimat Hanova

The National Medical Research Center for Otorhinolaryngology of the Federal Medico-Biological Agency of Russia

Email: fmkhanova@yahoo.com
ORCID iD: 0000-0001-9362-9139
SPIN-code: 5320-2821

MD, Cand. Sci. (Med.)

Russian Federation, Moscow

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Supplementary files

Supplementary Files
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1. Fig. 1. ISAC ImmunoCap allergy chip, patient D. 40 years old results, dated 23.04.2019.

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2. Fig. 2. The dynamics of rhinosinusitis with nasal polyps according to paranasal sinuses CT scan (September 2018 – September 2020): a ― image after endoscopic polysinusotomy was performed in September 2018 (polypous mass in maxillary, sphenoidal sinuses, in ethmoid sinuses); b ― image 24 month from the start of anti-IgE therapy (only parietal mucosal thickening in maxillary, sphenoidal sinuses, in ethmoid sinuses with airness restoration in paranasal sinuses).

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