Challenges of differential diagnosis of mediators-induced and bradykinin-induced angioedema shown by a clinical case series
- Authors: Manto I.A.1, Latysheva E.A.1, Timoshenko D.O.2, Latysheva T.V.1,3
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Affiliations:
- National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
- Pirogov Russian National Research Medical University (Pirogov Medical University)
- Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
- Issue: Vol 18, No 2 (2021)
- Pages: 131-137
- Section: Case reports
- URL: https://rusalljournal.ru/raj/article/view/1453
- DOI: https://doi.org/10.36691/RJA1453
Cite item
Abstract
Angioedema is caused by a local increase in vascular permeability induced by bradykinin or mast cell mediators. The main challenge of the differential diagnosis of angioedema lies in the fact that different pathophysiological processes may lead to a very similar clinical picture. Moreover, verification of the type of angioedema is crucial for selection of appropriate therapy. In 2020, a school for doctors “Chronic urticaria: scientific and medical accomplishments and practical aspects of patient management” was held on the basis of the National Research Center Institute of Immunology of the FMBA of Russia as part of the work of the reference center that provides expert assistance to patients with urticaria (GA²LEN UCARE). A clinical case series of related patients with hereditary angioedema due to a mutation in the PLG gene was presented to demonstrate the challenges of the differential diagnosis between types of angioedema. This article focused on the description of this series.
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About the authors
Irina A. Manto
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
Email: irina.manto@yandex.ru
ORCID iD: 0000-0001-6432-394X
SPIN-code: 7944-5159
MD, Research Associate
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522Elena A. Latysheva
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia
Email: ealat@mail.ru
ORCID iD: 0000-0002-1606-205X
SPIN-code: 2063-7973
MD, Dr. Sci. (Med.), Senior Research Associate
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522Daria O. Timoshenko
Pirogov Russian National Research Medical University (Pirogov Medical University)
Author for correspondence.
Email: d.o.timoshenko@gmail.com
ORCID iD: 0000-0002-7585-1390
SPIN-code: 2714-0906
Russian Federation, 1, Ostrovityanova, Moscow,117997
Tatiana V. Latysheva
National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia; Moscow State University of Medicine and Dentistry named after A.I. Evdokimov
Email: tvlat@mail.ru
ORCID iD: 0000-0003-1508-0640
SPIN-code: 8929-7644
MD, Dr. Sci. (Med.), Professor
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522; 20, building 1, Delegatskaya str., Moscow, 127473References
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