Is angioedema mast cell mediators-induced or bradykinin-induced? Challenges of differential diagnosis shown by a clinical case series

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Abstract

Angioedema occurs due to a local increase in vascular permeability induced by mediators: bradykinin or mast cell mediators. The main challenge of the differential diagnosis of angioedema lies in the fact that different pathophysiological processes may lead to a very similar clinical picture. At the same time, verification of the type of angioedema is crucially important for the proper therapy selection. In 2020, a school for doctors "Chronic urticaria: scientific and medical accomplishments and practical aspects of patient management" was held on the base of the National Research Center Institute of Immunology of the FMBA of Russia as part of the work of the reference center that provides expert assistance to patients with urticaria (GA²LEN UCARE). A clinical cases series of patients related to the same family with Hereditary Angioedema with a mutation in the PLG gene was presented at the event in order to demonstrate the challenges of differential diagnosis between different types of angioedema. This article focused on the description of this series.

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About the authors

Irina A. Manto

National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia

Email: irina.manto@yandex.ru
ORCID iD: 0000-0001-6432-394X
SPIN-code: 7944-5159
Russian Federation, 24, Kashirskoye shosse, Moscow, 115522

Elena A. Latysheva

National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia

Email: ealat@mail.ru
ORCID iD: 0000-0002-1606-205X
SPIN-code: 2063-7973

MD, Dr. Sci. (Med.)

Russian Federation, 24, Kashirskoye shosse, Moscow, 115522

Daria O. Timoshenko

Pirogov Russian National Research Medical University (Pirogov Medical University), 1, Ostrovityanova, Moscow

Author for correspondence.
Email: d.o.timoshenko@gmail.com
ORCID iD: 0000-0002-7585-1390
SPIN-code: 2714-0906
Russian Federation, 117997, 1, Ostrovityanova, Moscow, Russia

Tatiana V. Latysheva

National Research Center – Institute of Immunology Federal Medical-Biological Agency of Russia; Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

Email: tvlat@mail.ru
ORCID iD: 0000-0003-1508-0640
SPIN-code: 8929-7644

MD, Dr. Sci. (Med.), Professor

Russian Federation, 24, Kashirskoye shosse, Moscow, 115522; 20, building 1, Delegatskaya str., Moscow, 127473

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