Component allergy diagnostics as a tool for the management of patients with allergic diseases

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Abstract

Molecular diagnostics makes it possible to determine true and cross-reactivity differentially, which is of great clinical importance not only for the diagnosis of the true spectrum of sensitization, but also for the reasonable choice of pathogenetic therapy and prediction of the effectiveness and risks associated with allergen-specific immunotherapy (ASIT). Several clinical cases are presented as examples demonstrating the clarifying nature of molecular allergodiagnostics. In the first case, the detection of primary sensitization, which was conducted using ASIT with a causally significant allergen, led to the elimination of not only respiratory but also skin symptoms. In other clinical cases, patients had similar anamnesis and data from skin and laboratory studies. To clarify the indications for ASIT, correct choice of a therapeutic allergen and method of its administration, and the prognosis of the effectiveness of ASIT, it is necessary to identify the primary allergenic source that causes IgE-mediated sensitization. For this purpose, the patients were recommended to undergo laboratory diagnostic examinations to clarify the spectrum of sensitization. Component allergodiagnostics of ImmunoCAP made it possible to develop an individual management strategy for these patients.

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Molecular diagnostics makes it possible to determine true and cross reactivity differentially, which is of great clinical importance not only for the diagnosis of the true spectrum of sensitization, but also for the reasonable choice of pathogenetic therapy, prediction of the effectiveness and risks associated with allergenspecific immunotherapy. A number of clinical cases are presented as examples demonstrating the clarifying nature of molecular allergodiagnostics.

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About the authors

Ella V. Churyukina

Rostov State Medical University; Kuban State Medical University

Author for correspondence.
Email: echuryukina@mail.ru
ORCID iD: 0000-0001-6407-6117
SPIN-code: 8220-1439

MD, Cand. Sci. (Med.), Associate Professor

Russian Federation, 29, Nakhichevansky lane, Rostov-on-Don, 344022; Krasnodar

Maria V. Dudareva

Rostov State Medical University

Email: m.dudareva@rniiap.ru
ORCID iD: 0000-0003-3920-1224
SPIN-code: 5615-8920

Dr. Sci. (Biol.)

Russian Federation, 29, Nakhichevansky lane, Rostov-on-Don, 344022

Natalia V. Kolesnikova

Kuban State Medical University

Email: nvk24071954@mail.ru
ORCID iD: 0000-0002-9773-3408
SPIN-code: 9685-7584

Dr. Sci. (Biol.), Professor

Russian Federation, Krasnodar

Evgeny F. Filippov

Kuban State Medical University

Email: filippov-kuban@yandex.ru
ORCID iD: 0000-0001-5817-0924
SPIN-code: 5989-2521

MD, Dr. Sci. (Med.), Associate Professor

Russian Federation, Krasnodar

Olga P. Ukhanova

Stavropol State Medical University

Email: uhanova_1976@mail.ru
ORCID iD: 0000-0002-7247-0621
SPIN-code: 8287-2891

MD, Dr. Sci. (Med.), Professor

Russian Federation, Stavropol

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