Efficacy and safety of the antileukotriene drugs: relevant data. RAACI experts conclusion

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  • Authors: Il`ina N.I.1, Kurbacheva O.M.1, Nenasheva N.M.2, Astafieva N.G.3, Beltyukov E.K.4, Demko I.V.5, Zhestkov A.V.6, Osipova G.L.7
  • Affiliations:
    1. NRC Institute of Immunology FMBA of Russia
    2. Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russian Federation
    3. Saratov State Medical University named after V.I. Razumovsky
    4. Ural State Medical University
    5. Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University
    6. Samara State Medical University
    7. Pulmonology Research Institute FMBA of Russia
  • Issue: Vol 17, No 3 (2020)
  • Pages: 121-129
  • Section: Help to the practitioner
  • URL: https://rusalljournal.ru/raj/article/view/1395
  • DOI: https://doi.org/10.36691/RJA1395
  • Cite item
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Abstract


In many countries of the world and in Russia, in particular, the pharmacological use of antagonists of cysteinyl receptors LT1 (CysLTR) is a long­-proven and well­-proven pharmacotherapy of bronchial asthma (BA) and allergic rhinitis (AR) in adults and children.

Among antileukotriene drugs the most commonly used medication for the treatment of these diseases is the original montelukast, which is considered a safe drug associated with the appearance of only a few adverse reactions, usually not differing in type and frequency from those that occur with placebo. Currently, there are a large number of generics of montelukast, therefore, practitioners have many questions regarding the benefits and risks of montelukast therapy for patients with BA and AR.

In 2020 FDA (Food and Drug Administration USA) analyzed the risk of adverse events during Montelukast treatment and indicated them on the packaging of the drug (original montelukast and its generics). This contributed to the creation of an expert commission to study this issue and form an expert opinion, which is demonstrated in our publication.


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Natalya I. Il`ina

NRC Institute of Immunology FMBA of Russia

Email: instimmun@yandex.ru
ORCID iD: 0000-0002-3556-969X

Russian Federation, Moscow

head physician, NRC Institute of Immunology FMBA of Russia, MD, PhD, DSc, professor

Oksana M. Kurbacheva

NRC Institute of Immunology FMBA of Russia

Author for correspondence.
Email: kurbacheva@gmail.com
ORCID iD: 0000-0003-3250-0694

Russian Federation, Moscow

head of the Department of Bronchial Asthma, NRC Institute of Immunology FMBA of Russia, MD, PhD, DSc, professor

Natalya M. Nenasheva

Russian Medical Academy of Continuous Professional Education of the Ministry of Healthcare of Russian Federation

Email: 1444031@gmail.com
ORCID iD: 0000-0002-3162-2510

Russian Federation, Moscow

head of the Chair of Clinical Allergology, Russian Medical Academy of Continuous Professional Education of Ministry of Health of the Russian Federation, MD, PhD, DSc, professor

Natalya G. Astafieva

Saratov State Medical University named after V.I. Razumovsky

Email: astang@mail.ru
ORCID iD: 0000-0002-7691-4584

Russian Federation, Saratov

head of the Chair of Clinical Immunology and Allergology, FSBE Institution of Higher Education «Saratov State Medical University named after V. I. Razumovsky» of Ministry of Health of the Russian Federation, MD, PhD, DSc, professor

Evgenij K. Beltyukov

Ural State Medical University

Email: asthma@mail.ru
ORCID iD: 0000-0003-2485-2243

Russian Federation, Ekaterinburg

professor of the Department of Faculty Therapy, Endocrinology, Allergology and Immunology, FSBE Institution of Higher Education «Ural State Medical University» of Ministry of Health of the Russian Federation, chief freelance specialist allergist-immunologist of Ministry of Health of the Sverdlovsk Region and the Ural Federal District, MD, PhD, DSc, professor

Irina V. Demko

Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University

Email: demko64@mail.ru
ORCID iD: 0000-0001-8982-5292

Russian Federation, Krasnoyarsk

professor of the Department of Internal Diseases, «Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University» of Ministry of Health of the Russian Federation, chief physician-pulmonologist of the Siberian Federal District, chief allergist of the Siberian Federal District, chief pulmonologist and allergist of Ministry of Health of the Krasnoyarsk Region, MD, PhD, DSc, professor

Aleksandr V. Zhestkov

Samara State Medical University

Email: avzhestkov2015@yandex.ru
ORCID iD: 0000-0002-3960-830X

Russian Federation, Samara

head of the Chair of General and Clinical Microbiology, Immunology and Allergology, FSBE Institution of Higher Education «Samara State Medical University» of Ministry of Health of the Russian Federation, chief freelance specialist in allergology and immunology of Ministry of Health of the Samara Region; chief pulmonologist of the Volga Federal District, MD, PhD, DSc, professor

Galina L. Osipova

Pulmonology Research Institute FMBA of Russia

Email: osipovagl@mail.ru

Russian Federation, Moscow

head of the Clinical Research Department, Pulmonology Research Institute under FMBA of Russia, MD, PhD, DSc

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