Modern anti-IgE therapies in children with chronic spontaneous urticaria: clinical cases

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access


The diagnostics and treatment of chronic urticaria is still a pressing problem for specialists of different profiles. Despite the fact that the first line drugs for urticaria treatment are non-sedating H1- antihistamines, there are a number of patients who do not respond to these medications even in their increased doses. This article presents clinical cases of anti-IgE-therapy efficacy in children suffering from urticaria and angioedema.

CONCLUSION: The clinical cases demonstrate current possibilities of successful and safe anti-IgE-therapy of various clinical manifestations of chronic spontaneous urticaria and angioedema in children.

Full Text

Restricted Access

About the authors

Inna A. Larkova

The Federal Research Center for Nutrition, Вiotechnology and Food Safety

Author for correspondence.
ORCID iD: 0000-0001-7640-0754

Senior researcher of Allergy Department, MD

Russian Federation, Moscow

Vera A. Revyakina

The Federal Research Center for Nutrition, Вiotechnology and Food Safety

ORCID iD: 0000-0002-1149-7927

Head of Allergy Department

Russian Federation, Moscow


  1. Клиническая аллергология детского возраста с неотложными состояниями / под ред. Балаболкина И.И., Булгаковой В.А. М. : МИА, 2011.
  2. Российская Ассоциация Аллергологов и Клинических Иммунологов. Федеральные клинические рекомендации по диагностике и лечению крапивницы. М., 2018.
  3. Zuberbier T., Aberer W., Asero R., et al. The EAACI/GA²LEN/ EDF/WAO guideline for the definition, classification, diagnosis and management of urticaria // Allergy. 2018. Vol. 73. N 7. P. 1393–1414. doi: 10.1111/all.13397
  4. Horn MP, Pachlopnik JM, Vogel M, et al. Conditional autoimmunity mediated by human natural anti-Fc(epsilon)RIalpha autoantibodies? // FASEB J. 2001. N 12. P. 2268–2274.doi: 10.1096/fj.00-0890hyp
  5. Beck L.A., Bernstein J.A., Maurer M. A review of international recommendations for the diagnosis and management of chronic urticaria // Acta Derm Venereol. 2017. Vol. 97. N 2. P. 149–158. doi: 10.2340/00015555-2496
  6. Maurer М., Rosen K., Hsieh H.J., et al. Оmalizumab for the treatment of chronic idiopathic or spontaneous urticaria // N Engl J Med. 2013. Vol. 368. N 10. P. 924–935.doi: 10.1056/NEJMoa1215372
  7. Rosen K., Maurer M., Hsieh H., et al. Response to: ‘Omalizumab for the treatment of chronic idiopathic or spontaneous urticaria: a critical appraisal’ // Br J Dermatol. 2014. N 1. P. 15–16. doi: 10.1111/bjd.13075

Copyright © Pharmarus Print Media, 2021

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies