Biological therapy of allergic diseases during the COVID-19 pandemic

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The outbreak of the SARS-CoV-2-induced Coronavirus Disease 2019 (COVID-19) pandemic started in December 2019 in Wuhan, China, continued to spread across the globe and spanned 188 countries. Under the new circumstances treatment approach for T2 allergic diseases such as asthma, chronic hives, atopic dermatitis, and sinusitis with polyps has been changed. In the past years, new biological therapies – monoclonal antibodies for these diseases have been developed targeting different aspects of the type 2 immune response. New knowledge on the COVID-19 disease course raises many issues around the safety of biologicals in patients with active infection, as well as their interactions with antiviral medications. In Russia new biological therapies entered clinical practice but it’s effectiveness and safety still are not known.

This newsletter is based on “Considerations on Biologicals for Patients with allergic disease in times of the COVID-19 pandemic: an EAACI Statement” and the latest scientific data.

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About the authors

Elena S. Fedenko

NRCI Institute of Immunology FMBA of Russia

Author for correspondence.
ORCID iD: 0000-0003-3358-5087

head of Skin Allergy and Immunopathology Department, NRC Institute of Immunology FMBA of Russia, MD, PhD, professor

Russian Federation, Moscow

Olga G. Elisyutina

NRCI Institute of Immunology FMBA of Russia

ORCID iD: 0000-0002-4609-2591

leading researcher of Skin Allergy and Immunopathology Department, NRC Institute of Immunology FMBA of Russia, MD, PhD

Russian Federation, Moscow

Natalia I. Il`ina

NRCI Institute of Immunology FMBA of Russia

ORCID iD: 0000-0002-3556-969X

head physician, NRC Institute of Immunology FMBA of Russia, MD, PhD, professor

Russian Federation, Moscow


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Supplementary files

Supplementary Files
1. Figure."Iceberg" COVID-19 pandemic. In 10–20% of diagnosed cases, severe course, in 60% - mild to moderate. False negative RT-PCR tests in 10–20% of hospitalized patients with clinical presentation. Asymptomatic cases were identified by random screening of medical workers and in persons in close contact with patients. There is also a large number of asymptomatic at the bottom of the "iceberg" with a history of COVID-19 symptoms, not confirmed and not hospitalized. Individuals without symptoms have been reported although they have had close contact with sick relatives. The overall mortality rate in the world is 6%, and it tends to increase. Data on the number of people who recovered are inaccurate. Information is available at https: // www. and

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