The effectiveness of omalizumab in patients with severe chronic spontaneous urticaria (results of own clinical experience)

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BACKGROUND: Urticaria is one of the most common dermatoses and affects 15–25% of the population; chronic spontaneous urticaria occur in 1.8% of adults and in 0.1–3% of children. Second generation antihistamines are effective only in 45–77% of patients. The next steps of treatment include increase antihistamines dose and their combination with omalizumab.

AIM: To analyze own clinical experience and assess effectiveness of omalizumab in severe chronic spontaneous urticaria.

MATERIALS AND METHODS: Effectiveness of biological treatment with omalizumab was analyzed in 14 patients with severe chronic spontaneous urticaria.

RESULTS: The prescription of omalizumab in the basic therapy of patients with severe chronic spontaneous urticaria (CSU) allowed to reduce significantly the severity of clinical symptoms in 78.6% of patients, to abandon the use of systemic glucocorticosteroids and to achieve partial or complete control of the disease. It should be noted, that 28.5% of patients during the immunobiological therapy stopped taking second-generation antihistamines and the dosage was reduced to therapeutic in 35.7% of patients.

CONCLUSION: Omalizumab is a highly effective in patients with severe chronic spontaneous urticaria.

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About the authors

Olesya V. Skorokhodkina

Kazan State Medical University

Author for correspondence.
ORCID iD: 0000-0001-5793-5753

head of the Department of Clinical Immunology with Allergology of Kazan State Medical University, MD, PhD, professor

Russian Federation, Kazan

Aliya R. Klyucharova

Kazan State Medical University; Republican Clinical Hospital

ORCID iD: 0000-0001-9045-5831

assistant, Department of Clinical Immunology with Allergology of Kazan State Medical University, MD, Phd, allergologist-immunologist

Russian Federation, Kazan

Alexey V. Luntsov

Republican Clinical Hospital

ORCID iD: 0000-0003-2552-2107

head of the Cеnter of Clinical Immunology, PhD, allergologist-immunologist

Russian Federation, Kazan


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Supplementary files

Supplementary Files
1. Fig. 1. Distribution of patients with HSC according to the control of symptoms of the disease during therapy with omalizumab

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2. Fig. 2. Changes in HCK indices in patients during the course of omalizumab (group I)

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3. Fig. 3. Changes in HCK indices in patients during the course of omalizumab (group II)

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4. Fig. 4. Changes in HCK indices in patients during the course of omalizumab (group III)

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