The effectiveness of omalizumab in patients with severe chronic spontaneous urticaria (results of own clinical experience)
- Authors: Skorokhodkina O.V.1, Klyucharova A.R.1,2, Luntsov A.V.2
- Kazan State Medical University
- Republican Clinical Hospital
- Issue: Vol 17, No 3 (2020)
- Pages: 74-81
- Section: Original studies
- URL: https://rusalljournal.ru/raj/article/view/1379
- DOI: https://doi.org/10.36691/RJA1379
- Cite item
BACKGROUND: Urticaria is one of the most common dermatoses and affects 15–25% of the population; chronic spontaneous urticaria occur in 1.8% of adults and in 0.1–3% of children. Second generation antihistamines are effective only in 45–77% of patients. The next steps of treatment include increase antihistamines dose and their combination with omalizumab.
AIM: To analyze own clinical experience and assess effectiveness of omalizumab in severe chronic spontaneous urticaria.
MATERIALS AND METHODS: Effectiveness of biological treatment with omalizumab was analyzed in 14 patients with severe chronic spontaneous urticaria.
RESULTS: The prescription of omalizumab in the basic therapy of patients with severe chronic spontaneous urticaria (CSU) allowed to reduce significantly the severity of clinical symptoms in 78.6% of patients, to abandon the use of systemic glucocorticosteroids and to achieve partial or complete control of the disease. It should be noted, that 28.5% of patients during the immunobiological therapy stopped taking second-generation antihistamines and the dosage was reduced to therapeutic in 35.7% of patients.
CONCLUSION: Omalizumab is a highly effective in patients with severe chronic spontaneous urticaria.
Olesya V. SkorokhodkinaKazan State Medical University
head of the Department of Clinical Immunology with Allergology of Kazan State Medical University, MD, PhD, professor
Aliya R. KlyucharovaKazan State Medical University; Republican Clinical Hospital
assistant, Department of Clinical Immunology with Allergology of Kazan State Medical University, MD, Phd, allergologist-immunologist
Alexey V. LuntsovRepublican Clinical Hospital
head of the Cеnter of Clinical Immunology, PhD, allergologist-immunologist
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|1.||Fig. 1. Distribution of patients with HSC according to the control of symptoms of the disease during therapy with omalizumab||View (180KB)||Indexing metadata|
|2.||Fig. 2. Changes in HCK indices in patients during the course of omalizumab (group I)||View (50KB)||Indexing metadata|
|3.||Fig. 3. Changes in HCK indices in patients during the course of omalizumab (group II)||View (30KB)||Indexing metadata|
|4.||Fig. 4. Changes in HCK indices in patients during the course of omalizumab (group III)||View (28KB)||Indexing metadata|