The features of the pollen sensitization in seasonal allergic rhinitis patients with gastrointestinal tract inflammatory diseases comorbidity

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BACKGROUND: Allergic diseases and gastrointestinal tract diseases can influence on the natural course of each other.

AIM: To study the sensitization profile in patients with comorbidity of seasonal allergic rhinitis (SAR) and upper gastrointestinal tract inflammatory diseases (UGITID).

MATERIALS AND METHODS: 112 adult residents of Volgograd city suffering from SAR but without perennial symptoms and sensitization to indoor allergens have been included in the study. 31/112 patients had H. pylori­-negative and 38/112 H. pylori­-positive UGITID. Control group consisted of 43/112 patients without gastrointestinal diseases. Skin prick-­testing with 3 groups of pollen allergens have been carried out.

RESULTS: 75.9% of patients were sensitized to weed pollen; sensitization to grass pollen was in 1.5–3 times less, and 10.5% of patients (4/38) had positive tests with birch pollen. The sensitization to quinoa and ragweed in SAR and H. pylori«–»­-UGITID patients was comparable with control group but less common with wormwood, sumpfweed allergens. The sensitization in SAR patients and H. pylori«+»­-UGITID was similar to the control group, but positive SPT with sunflower and corn allergens were rare then in control group.

CONCLUSION: Weed pollen allergens prevail in sensitization spectrum of adult Volgograd residents with SAR. Sensitization to goose-foot and ragweed is common less in SAR patients and H. pylori«–»­-UGITID but to graminea grass and birch pollen is more often. It may be supposed that the UGITID are predisposing factors to the sensitization to cross-­reacting plant food allergens. At the same time supposed immunomodulating action of H. pylori make the differences between AR patients with H. pylori«+»­-UGITID or H. pylori«–»­-UGITID minor.

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About the authors

Natalia S. Iraklionova

Volgograd State Medical University

ORCID iD: 0000-0003-3186-260X

assistant of the Department of Immunology and Allergology, Volgograd State Medical University

Russian Federation, Volgograd

Eleonora B. Belan

Volgograd State Medical University

Author for correspondence.
ORCID iD: 0000-0003-2674-4289

head of the Department of Immunology and Allergology, Volgograd State Medical University MD, PhD, Professor

Russian Federation, Volgograd

Svetlana V. Turkina

Volgograd State Medical University

ORCID iD: 0000-0002-8844-2465

pofessor of the Department of Internal Medicine of the Pediatrics and Dental Faculties, Volgograd State Medical University, MD, PhD

Russian Federation, Volgograd

Anna A. Panina

Volgograd State Medical University; Consultative Diagnostic Clinics № 2

ORCID iD: 0000-0003-2750-8579

head of the Consultative Diagnostic Clinic № 2, Volgograd, PhD

Russian Federation, Volgograd

Tatiana L. Sadchikova

Volgograd State Medical University

ORCID iD: 0000-0001-5762-0196

associate professor of the Immunology and Allergology Department, Volgograd State Medical University, PhD

Russian Federation, Volgograd

Andrey S. Klyausov

Volgograd State Medical University

ORCID iD: 0000-0003-1631-6010

associate professor of the Immunology and Allergology Department, Volgograd State Medical University, PhD

Russian Federation, Volgograd


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Supplementary files

Supplementary Files
1. Figure. Soil and vegetation characteristics of the Volgograd region

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