Periostin as a biomarker for the diagnosis of asthma in preschool children

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access



Full Text

Restricted Access

About the authors

N V Shakhova

Altai State Medical University

Author for correspondence.
Barnaul, Russian Federation

E M Kamaltynova

Siberian State Medical University

Tomsk, Russian Federation

T S Kashinskay

Altai State Medical University

Barnaul, Russian Federation


  1. Akids CA, Agache I. Global athlas of asthma. Zurich, European Academy of Allergy and Clinical Immunology; 2013. p. 7 -9
  2. Соколова Л.В. Диагностичекие ошибки при бронхиальной астме у детей. // Пульмонология. - 2002.-N 1.-С.72-77
  3. Global Initiative for Asthma (updated 2018) 2018. Avaliable at:
  4. James A, Hedlin G. Biomarkers for the phenotyping and monitoring of asthma in children. Curr Treat Options Allergy 2016; 3(4): 439-452.doi: 10.1007/s40521-016-0106-0
  5. Sidhu SS, Yuan S, Innes AL, et al. Roles of epithelial cell-derived periostin in TGF- ß activation, collagen-production, and collagen gel elasticity in asthma. ProcNatlAcadSci USA. 2010; 107: 14170-5. doi:10.1073/ pnas.1009426107.PMID:20660732.
  6. Makita K, Mikami Y, Matsuzaki H, et al. Mechanism of periostin production in human bronchial smooth muscle cells. Int Arch Allergy Immunol. 2018; 175(1-2): 26-35. doi: 10.1159/000485892
  7. Takayama G, Arima K, Kanaji T, et al. Periostin: a novel component of subepithelial fibrosis of bronchial asthma downstream of IL-4 and IL-13 signals. J Allergy Clin-Immunol 118:98-104. doi: 10.1016/j.jaci.2006.02.046
  8. Takahashi K, Meguro K, Kawashima H, et al. Serum periostin levels serve as a biomarker for both eosinophilic airway inflammation and fixed airflow limitation in well-controlled asthmatics. Journal of Asthma 2018; 12: 1-8. doi: 10.1080/02770903.2018.1455855
  9. James A, Janson C, Malinovschi A et al. Serum periostin relates to type-2 inflammation and lung function in asthma; data from the large population-based cohort Swedish GA(2)LEN. Allergy. 2017; 72(11): 1753-1760. doi: 10.1111/all.13181
  10. Bobolea I, Barranco P, Del Pozo V et al. Sputum periostin in patients with different severe asthma phenotypes. Allergy 2015; 70(5):540-6. doi: 10.1111/all.12580
  11. Inoue T, Akashi K, Watanabe M et al. Periostin as a biomarker for the diagnosis of pediatric asthma. Pediatr Allergy Immunol 2016: 27(5):521-526 doi: 10.1111/ pai.12575
  12. El Basha NR, Osman HM, Abdelaal AA et al. Increased expression of serum periostin and YKL40 in children with severe asthma and asthma exacerbation. J Investig Med. 2018; 66(8):1102-1108. doi: 10.1136/jim-2017000680
  13. Tartibi HM, Bahna SL. Clinical and biological markers of asthma control. Expert Rev ClinImmunol. 2014; 10(11): 1453-1461. doi: 10.1586/1744666X.2014.962516
  14. Matsumoto H. Serum Periostin: A novel biomarker for Asthma Management. Allergol Int. 2014 ; 63(2): 153-60. doi: 10.2332/allergolint.13-RAI-0678
  15. Matsusaka M, Kabata H, Fukunaga K. et al. Phenotype of asthma related with high serum periostin levels. Allergol Int. 2015; 64(2): 175-80. doi: 10.1016/j. alit.2014.07.003.
  16. Song JS, You JS, Jeong SI, et al. Serum periostin levels correlate with airway hyper-responsiveness to metha-choline and mannitol in children with asthma. Allergy. 2015; 70: 674-681.
  17. Масальский С.С., Калмыкова А.С., Уханова О.П. Комплексная оценка сывороточного периостина - нового маркера аллергического воспаления при неконтролируемой бронхиальной астме у детей // Российский аллергологический журнал. - 2018. -Т. 15.- №1- С. 55-57.
  18. Lopez-Guisa JM, Powers C, File D, et al. Airway Epithelial cells from asthmatic children differentially expressproremodeling factors. J Allergy ClinImmunol. 2012; 129: 990-997. doi: 10.1016/jjaci.2011.11. 035.
  19. Johansson MW, Evans MD, Crisafi GM et al. Serum periostin is associated with type 2 immunity in severe asthma. J Allergy ClinImmunol 2016; 137(6): 19041907. doi: 10.1016/jjaci.2015.12.1346.
  20. Simpson JL, Yang IA, Upham JW et al. Periostin levels and eosinophilic inflammation in poorly-controlled asthma. BMC Pulm Med. 2016; 16(1) :67. doi: 10.1186/ s12890-016-0230-4.
  21. Habernau Mena A, Del PozoAbejon V, Rodriguez Vidigal FF, Bobadilla Gonzalez P. Role of periostin in uncontrolled asthma in children. (DADO study). J Investig Allergol Clin Immunol 2017; 27 (5):291-298. doi: 10.18176/jiaci.0144.
  22. Konradsen JR, Skantz E, Nordlund B et al. Predicting asthma morbidity in children using proposed markers of Th2-type inflammation. Pediatr Allergy Immunol. 2015;26(8):772-9. doi: 10.1111/pai.12457.
  23. Yavuz ST, Bagci C, Bolat A et al. Serum periostin levels are associated with asthma severity in children. Special Issue: Abstracts from the European Academy of Allergy and Clinical Immunology Congress, 26-30 May 2018, Munich, Germany. 2018; 73(105): S 903



Abstract - 63

PDF (Russian) - 1


Article Metrics

Metrics Loading ...


Copyright (c) 2019 Russian Allergological Journal

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies