Viral bronchial asthma: immune mechanisms of the disease

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The immune mechanisms involved in the pathogenesis of virus-induced bronchial asthma are extremely diverse and depend on many factors, including the etiological agent that caused this clinical pathology. However, there are characteristic features that manifest themselves in the majority of patients with bronchial asthma, who suffer from respiratory infections.

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About the authors

V A Shashel

Kuban Medical University; Regional Clinical Hospital for Children

Author for correspondence.
г. Краснодар

V N Firsova

Kuban Medical University; Regional Clinical Hospital for Children

г. Краснодар

M M Trubilina

Kuban Medical University; Regional Clinical Hospital for Children

г. Краснодар


  1. Баранов А.А., Хаитова Р.М. Клинические рекомендации для педиатров. - Москва: Союз педиатров России, 2008-2009. - 240 с.
  2. Захарова И.А., Белевский А.С. Возможности лечения вирусиндуцированной бронхиальной астмы. // Практическая пульмонология. 2017; №3: c.3-6.
  3. Суханова Н. А. Латентная инфекция у детей с бронхиальной астмой. // Российская отоларингология. 2010; №1: с. 127-137.
  4. Царев С.В. Вирусиндуцированная бронхиальная астма: особенности течения и лечебная тактика. // ЭФФЕКТИВНАЯ ФАРМАКОТЕРАПИЯ. Аллергология и иммунология. 2005; №1 (20).
  5. Царев С.В., Хаитов М.Р. Роль респираторных вирусов при бронхиальной астме // РМЖ. 2009; №2: c'. 136.
  6. Bentley J.K., Sajjan U.S., Dzaman M.B., Jarjour N.N., Lee W.M., Gern J.E., Hershenson M.B. Rhinovirus colocalizes with CD68- and CD11b-positive macrophages following experimental infection in humans. // J. Allergy Clin Immunol. 2013; 132(3):758-761. doi: 10.1016/ j.jaci.2013.04.020.
  7. Bohmwald K., Espinoza J.A., Pulgar R.A., Jara E.L., Kalergis A.M. Functional Impairment of Mononuclear Phagocyte System by the Human Respiratory Syncytial Virus. // Front Immunol. 2017; 8:1643. doi: 10.3389/ fimmu.2017.01643.
  8. Culley F.J., Pennycook A.M.J., Tregoning J.S., Hussell T., and Openshaw P.J. Differential Chemokine Expression following Respiratory Virus Infection Reflects Th1- or Th2-Biased Immunopathology. // J Virol. 2006; 80(9): 4521-4527.
  9. Ducharme F.M., Zemek R., Chauhan B.F., Gravel J., Chalut D., Poonai N., Guertin M.C., Quach C., Blondeau L., Laberge S. Factors associated with failure of emergency department management in children with acute moderate or severe asthma: a prospective, multicentre, cohort study. // Lancet Respir Med. 2016; 4: 990-998. doi: 10.1016/S2213-2600(16)30160-6.
  10. Han M., Rajput C., Ishikawa T., Jarman C.R., Lee J., Hershenson M.B. Small Animal Models of Respiratory Viral Infection Related to Asthma. // Viruses. 2018; 10(12): 682. doi: 10.3390/v10120682.
  11. Lee K., Hegele R., Manfreda J., Wooldrage K., Beecker A.B., Ferguson A.C., Dimich-Ward H., Warson W.T., Chan-Yeung M. Relationship of early childhood viral exposures to respiratory symptoms, onset of possible asthma and atopy in high risk children: the Canadian Asthma Primary Prevention Study. // Pediatric Pulmonology. 2007; 42(3): 290-297.
  12. Lewis T.C., Metitiri E.E., Mentz G.B., Ren X., Carpenter A.R., Goldsmith A.M., Wicklund K.E., Eder B.N., Comstock A.T., Ricci J.M., Brennan S.R., Washington G.L., Owens K.B., Mukherjee B., Robins T.G., Batterman S.A., Hershenson M.B. Influence of viral infection on the relationships between airway cytokines and lung function in asthmatic children. // Respir Res. 2018; 19(1): 228. doi: 10.1186/s12931-018-0922-9.
  13. Nakagome K., Nagata M. Involvement and Possible Role of Eosinophils in Asthma Exacerbation. // Front Immunol. 2018; 9: 2220. doi: 10.3389/fim-mu.2018.02220.
  14. Robinson D.S., Hamid Q., Ying S., Tsicopoulos A., Barkans J., Bentley A.M., Corrigan C., Durham S.R., Kay A.B. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma. // N. Engl. J. Med. 1992; 326: 298-304.
  15. Woodruff, P. G., Modrek, B., Choy, D.F.; Jia, G., Abbas, A.R., Ellwanger, A., Arron, J.R., Koth, L.L., Fahy, J.V. T-helper Type 2-driven Inflammation Defines Major Subphenotypes of Asthma. // Am. J. Respir. Crit. Care Med. 2009; 180: 388-395. doi: 10.1164/ rccm.200903-0392OC.
  16. Zhu J., Message S.D., Mallia P., Kebadze T., Contoli M., Ward C.K., Barnathan E.S., Mascelli M.A., Kon O.M., Papi A., Stanciu L.A., Edwards M.R., Jeffery P.K., Johnston S.L. Bronchial mucosal IFN-a/ß and pattern recognition receptor expression in patients with experimental rhinovirus-induced asthma exacerbations. // J Allergy Clin Immunol. 2018; Apr 24. pii: S0091-6749(18)30610-9. doi: 10.1016/jjaci.2018.04.003.



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