Activation of blood cells by LPS and DpE: the role of sMD-2 and p38 MAPK in the development of allergic inflammation

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About the authors

N I Kosyakova

Hospital of Pushchino Scientific Center, Russian Academy of Sciences

Author for correspondence.
Email: nelia_kosiakova@mail.ru
Pushchino, Russia Federation

Y V Radzyukevich

Hospital of Pushchino Scientific Center, Russian Academy of Sciences; PSCBR RAS Institute of Basic Biological Problems RAS

Email: nelia_kosiakova@mail.ru
Pushchino, Russia Federation

A A Morozova

Hospital of Pushchino Scientific Center, Russian Academy of Sciences; PSCBR RAS Institute of Basic Biological Problems RAS

Email: nelia_kosiakova@mail.ru
Pushchino, Russia Federation

I R Prokhorenko

Hospital of Pushchino Scientific Center, Russian Academy of Sciences; PSCBR RAS Institute of Basic Biological Problems RAS

Email: nelia_kosiakova@mail.ru
Pushchino, Russia Federation

References

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  2. Nagai Y., Akashi S., Nagafuku M., Ogata M. et al. Essential role of MD-2 in ЛПС responsiveness and TLR4 distribution // Nature Immun. - 2002. - Vol. 3. -P. 667 - 672.
  3. Liao E. C., Hsieh C. W., Chang C. Y., Yu S. J. et al. Enhanced allergic inflammation of Der p 2 affected by polymorphisms of MD-2 promoter // Allergy Asthma Immunol. Res. - 2015. - Т. 7. - №. 5. - С. 497-506.
  4. Radzyukevich Y. V., Kosyakova N. I., Prokhorenko I. R. Synergistic effect of Dermatophagoides pteronyssinus allergen and Escherichia coli lipopolysaccharide on human blood cells // PLOS ONE. - 2018. - Vol.13. - P. e0207311.
  5. Trompette A., Divanovic S., Visintin A., Blanchard C. et al. Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein // Nature. - 2009. - Vol. 457. - P. 585-588.
  6. Visintin A., Mazzoni A., Spitzer J. A., Segal, D. M. Secreted MD-2 is a large polymeric protein that efficiently confers lipopolysaccharide sensitivity to Toll-like receptor 4 // PNAS. - 2001. - Vol. 98. - P. 12156-12161.
  7. Tsukamoto H., Ihara H., Ito R., Ukai I. et al. MD-2-dependent human Toll-like receptor 4 monoclonal antibodies detect extracellular association of Toll-like receptor with extrinsic soluble MD-2 on the cell surface // Biochem. Bioph. Res. Co. - 2013. - Vol. 440. - P. 31-36.
  8. Prokhorenko I., Morozova A., Kabanov D., Grachev S. Der p 2 from Dermatophagoides pteronyssinus potentiates the endotoxic activity of lipopolysaccharide from Escherichia coli // Intensive Care Med. Exp. - 2017 -Vol. 5 (Suppl. 1). - P. S3-S4.
  9. Fehr S., Unger A., Schaeffeler E., Herrmann S. et al. Impact of p38 MAP kinase inhibitors on LPS-induced release of TNF-a in whole blood and primary cells from different species // Cell. Physiol. Biochem. - 2015. -Vol. 36. - P. 2237-2249.
  10. Fitzgerald K. A., Rowe D. C., Barnes B. J., Caffrey D. R. et al. LPS-TLR4 signaling to IRF-3/7 and NF-kB involves the toll adapters TRAM and TRIF // J. Exp. Med. - 2003. - Vol. 198. - P. 1043-1055.
  11. Ngkelo A., Meja K., Yeadon M., Adcock I. et al. LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and G i a dependent PI-3kinase signaling

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