The role of CYP3A5 (rs776746) gene polymogene polymorphism in the efficacy of bronchial asthma therapy in children

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About the authors

A K Zastrozhina

Children’s City Polyclinic No.42 of the Moscow Healthcare Department

Author for correspondence.

I N Zakharova

Russian Medical Academy of Postgraduate Education of Russian Ministry of Health


D A Sychev

Russian Medical Academy of Postgraduate Education of Russian Ministry of Health



  1. Поликарпов А.В., Александрова Г.А., Голубева Н.А. Статистические материалы. Общая заболеваемость детского населения России ( 0 - 14 лет) в 2017 году. Часть VI. М.: 2018; 144. [Polikarpov A.V., Aleksandrova G.A., Golubeva N.A. Statistical materials. The overall incidence of the child population of Russia (0-14 years) in 2017. Part VI. Moscow: 2018; 144. (in Russ)] Электронный доступ: https://www.
  2. Mallola J, Crane J, von Mutius E, Odhiambo J, Keil U, Stewart A, the ISAAC Phase Three Study Group The International Study of Asthma and Allergies in Childhood (ISAAC) phase three: a global synthesis. Allergol Immunopathol (Madr) 2013;41(2):73-85.
  3. Global Strategy for Asthma Management and Prevention (2018 update).
  4. Национальная программа «Бронхиальная астма у детеи. Стратегия лечения и профилактика». 5-е изд., перераб. и доп. М.: Оригинал-макет, 2017. [National program «Bronchial asthma in children. Treatment strategy and prevention. 5th revised and enlarged edition. M.: Original-maket, 2017 (In Russ)]
  5. Федеральные клинические рекомендации Бронхиальная астма у детей. 2017год. [Federal clinical guidelines. Bronchial asthma in children. 2017 (In Russ)]
  6. Murai T., Reilly C.A., Ward R.M., Yost G.S. The inhaled glucocorticoid fluticasone propionate efficiently inactivates cytochrome P450 3A5, a predominant lung P450 enzyme. Chem Res Toxicol. 2010; 23:1356-1364.
  7. Пономаренко Т.М., Сычёв Д.А., Чикало А.О., Бердникова Н.Г., Кукес В.Г. Система цитохрома Р450 в лёгких: роль в патогенезе заболеваний и фармакокинетике лекарственных средств/ Журнал Фармакокинетика и фармакодинамика, 2012; 1(4)
  8. (Ponomarenko T.M., Sychov D.A., Chikalo A.O., Berdnikova N.G., Kukes V.G. Cytochrome P450 system in the lungs: role in the pathogenesis of diseases and pharmacokinetics of drugs. Pharmacokinetics and Pharmacodynamics. 2012; 1(4) (In Russ))
  9. Застрожина А.К., Сычев Д.А. Фармакогенетические аспекты эффективности и безопасности ингаляционных глюкокортикостероидов в лечении бронхиальной астмы. Клин фармакотер 2018;27(4):64-68. doi: 10.32756/0869- 5490-2018-5-64-68.
  10. (Zastrozhina A.K., Sy'chev D.A. Pharmacogenetic aspects of the efficacy and safety of inhaled glucocorticosteroids in the treatment of bronchial asthma. Clin Pharm 2018;27(4):64-68. (In Russ))
  11. Price A.C., Sisson J.R., Pereira A., Dallow N., Daley-Yates P.T. Beclomethasone dipropionat: absolute bioavailability, pharmacokinetics and metabolism following intravenous, oral, intranasal and inhaled administration in men // Br. J. Clin. Pharmacol. 2001; 51: 400-409.
  12. Quaranta S., Chevalier D., Allorfe D., Lo-Guidice J.M., Migot-Nabias F., Kenani A., et al., Ethnic differences in the distribution of CYP3A5 gene polymorphisms. Xenobiotica. 2006;36:1191-200.
  13. Thum T., Erpenbeck V.J., Moeller J., Hohlfeld J.M., Krug N., Borlak J. Expression of Xenobiotic Metabolizing Enzymes in Different Lung Compartments of Smokers and Nonsmokers. Environ Health Perspect. 2006 Nov;114(11):1655-61.
  14. Seo T., Pahwa P., McDuffie H.H., Yurube K., Egoshi M., Umemoto Y., et al. Association between cytochrome P450 3A5 polymorphism and the lung function in Saskatchewan grain workers. Pharmacogenet Genomics. 2008 Jun;18(6):487-93.
  15. Stockmann C., Fassl B., Gaedigk R., Nkoy F., Uchida D.A., Monson S., et al. Fluticasone propionate pharmacogenetics: CYP3A4*22 polymorphism and pediatric asthma control. J Pediatr 2013;162:1222-7, 1227.e1-2.
  16. Stockmann C., Reilly C.A., Fassl B., Gaedigk R., Nkoy F., Stone B., et al. Effect of CYP3A5*3 on asthma control among children treated with inhaledbeclomethasone. J Allergy Clin Immunol. 2015 Aug;136(2):505-7.
  17. Juniper EF, Gruffydd-Jones K, Ward S, Svensson K. Asthma Control Questionnaire in children: validation, measurement properties, interpretation. Eur Respir J 2010;36:1410-6.
  18. Nathan RA, Sorkness CA, Kosinski M, et al. Development of the asthma control test: a survey for assessing asthma control. J Allergy Clin Immunol 2004;113:59-65.
  19. Liu AH, Zeiger R, Sorkness C, et al. Development and cross-sectional validation of the Childhood Asthma Control Test. J Allergy Clin Immunol 2007;119:817-25.



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