Janus kinase inhibitors efficacy for the treatment of adult atopic dermatitis in real clinical practice

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Abstract

Atopic dermatitis is a common chronic dermatosis characterized by a wide variability of endotypes and phenotypes.

Approaches to the treatment of atopic dermatitis are currently undergoing significant changes, especially in patients with moderate and severe forms of atopic dermatitis. JAK inhibitors according to the results of numerous studies have shown their efficacy in the treatment of various immune-mediated dermatological diseases such as atopic dermatitis, vitiligo, focal alopecia and psoriasis, etc.

The article presents the experience of treating adult patients suffering from a severe form of atopic dermatitis with the selective JAK-1 inhibitor upadacitinib. The observations presented are of particular interest due to the fact that the patients were treated with upadacitinib monotherapy. It should be noted that the drug is highly effective against itching. No adverse events (including the development of infectious diseases, hematological disorders) were registered during dynamic observation (according to the results of laboratory studies).

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About the authors

Evgeniya A. Shatokhina

Central State Medical Academy of Department of Presidential Affairs; Lomonosov Moscow State University, Medical Scientific and Educational Center

Author for correspondence.
Email: e.a.shatokhina@gmail.com
ORCID iD: 0000-0002-0238-6563
SPIN-code: 3827-0100
Scopus Author ID: 57189575975

MD, Dr. Sci. (Med.), Professor

Россия, Moscow; Moscow

Aleksandra S. Polonskaia

Central State Medical Academy of Department of Presidential Affairs

Email: dr.polonskaia@gmail.com
ORCID iD: 0000-0001-6888-4760
Россия, Moscow

Anastasiya Yu. Syryseva

Central State Medical Academy of Department of Presidential Affairs

Email: syryseva.a@yandex.ru
ORCID iD: 0000-0001-9585-8373

ординатор кафедры

Россия, Moscow

Anna V. Michenko

Central State Medical Academy of Department of Presidential Affairs; Lomonosov Moscow State University, Medical Scientific and Educational Center

Email: amichenko@mail.ru
ORCID iD: 0000-0002-2985-5729

MD, Cand. Sci. (Med), Assistant Professor

Россия, Moscow; Moscow

Maksim N. Shatokhin

Russian Medical Academy of Continuous Professional Education

Email: m.n.shatokhin@gmail.com
ORCID iD: 0000-0002-1285-7357

MD, Dr. Sci. (Med.), Professor

Россия, Moscow

Larisa S. Kruglova

Central State Medical Academy of Department of Presidential Affairs

Email: kruglovals@mail.ru
ORCID iD: 0000-0002-5044-5265

MD, Dr. Sci. (Med.), Professor

Россия, Moscow

References

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Supplementary files

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2. Fig. 1. JAK/STAT signaling path.

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3. Fig. 2. Patient A., born in 1971, with severe atopic dermatitis in the acute stage: The dynamics of the skin process during therapy with upadacitinib.

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4. Fig. 3. Patient О., born in 1989, with severe atopic dermatitis in the acute stage: Dynamics of the skin process during therapy with upadacitinib.

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5. Fig. 4. Patient O., 7 months after the start of upadacitinib therapy.

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6. Fig. 5. Patient A. Dynamics of diagnostic indices SCORAD and DLQI within 2 months during therapy with upadacitinib.

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7. Fig. 6. Pation O. Dynamics of diagnostic indices SCORAD, EASI and DLQI within 7 months during therapy with upadacitinib.

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