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No metabolites impact in allergic inflammation regulation and their contribution to remodelling bronchi mucous in bronchial asthma patients
- Authors: Ogorodova LM1, Kozina OV1, Gereng EA1, Ogorodova LM1, Kozina OV1, Gereng EA1
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Affiliations:
- Issue: Vol 6, No 5 (2009)
- Pages: 11-17
- Section: Articles
- Submitted: 10.03.2020
- Published:
- URL: https://rusalljournal.ru/raj/article/view/1025
- DOI: https://doi.org/10.36691/RJA1025
- ID: 1025
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Abstract
Material and methods. Morphological and morphometrical methods of investigation of bronchi mucous of 39 BA patients were used, IL-4, TNF-α, INF-g, IL-8, nitrite, 3-nitrotyrosine, nitrosoglutathion levels in bronchoalveolar washout were investigated, nitrite concentration in condensate of the exhaled air was measured. Results. The increased level of IL-4, TNF-α, INF-g, IL-8 in bronchoalveolar washout is associated with persistent Th2-inflammation. The BA severity correlate with highest IL-8, TNF-a, INF-g, nitrite and 3-nitrotyrosine level but with nitrosoglutathion deficit and in general is associated with structured architectonics bronchi mucous abnormalities.
Conclusion. The association of toxic NO metabolites, pro-inflammation cytokines levels, bronchi mucous path-omorphological abnormalities with clinical signs of BA confirms the role of toxic NO metabolites in development of Th2-inflammations.
About the authors
L M Ogorodova
O V Kozina
Email: ovkozina2006@rambler.ru
E A Gereng
L M Ogorodova
O V Kozina
E A Gereng
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