Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press92310.36691/RJA923ArticlesСтатьиTreatment approaches in small bronchi inflammatory control in bronchial asthma patientsТерапевтические подходы к контролю воспаления на уровне мелких бронхов при бронхиальной астмеBudnevskiyA VБудневскийАндрей Валериевич

Voronezh N.N. Burdenko State Medical Academy

ГОУ ВПО «Воронежская государственная медицинская академия им. Н.Н. Бурденко Федерального агентства по здравоохранению и социальному развитию»

budnev@list.ruBurlachukV TБурлачукВ Т

Voronezh N.N. Burdenko State Medical Academy

ГОУ ВПО «Воронежская государственная медицинская академия им. Н.Н. Бурденко Федерального агентства по здравоохранению и социальному развитию»

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Voronezh N.N. Burdenko State Medical Academy

ГОУ ВПО «Воронежская государственная медицинская академия им. Н.Н. Бурденко Федерального агентства по здравоохранению и социальному развитию»

Voronezh N.N. Burdenko State Medical AcademyГОУ ВПО «Воронежская государственная медицинская академия им. Н.Н. Бурденко Федерального агентства по здравоохранению и социальному развитию»1508201074NO04 (2010)№4 (2010)859410032020Copyright ©; 2009, Pharmarus Print MediaCopyright ©; 2009, Фармарус Принт Медиа2009Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/923

This article reviews the significance of distal airways inflammation in asthma, current methods of investigations and therapeutic approaches to control inflammation at the level of small bronchi. It is demonstrated that inflammation in most asthma patients involves all airways including the small bronchi. The new drugs targeting distal airways, including extrafine formulations of inhaled steroids and P2-agonists (beclomethazone/formoterol (Fostair), can successfully treat pathologic process in small bronchi of asthma patients.

В обзоре представлены современные данные о роли дистальных отделов легких у больных БА, методах исследования и терапевтических подходов к контролю воспаления на уровне мелких бронхов. Показано, что у большинства пациентов воспалительный процесс охватывает все дыхательные пути, в т. ч. и бронхи мелкого калибра. Появление новых лекарственных препаратов, воздействующих на дисталь-ные отделы легких, в т. ч. новых экстрамелкодисперсных лекарсятвенных форм иГКС и Р2-агонистов (беклометазон/формотерол (Фостер)) позволило целенаправленно воздействовать на патологические процессы в мелких бронхах у больных БА.

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