Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press86510.36691/RJA865ArticlesСтатьиHelicobacter pylori infection: regulatory role of cytokines in inflammation and allergyИнфекция Helicobacter pylori: регуляторная роль цитокинов при воспалении и аллергииVaryushinaE AВарюшинаЕлена Анатольевна

State Scientific Center State Research Institute of Highly Pure Biopreparations

ФГУП «Государственный научно-исследовательский институт особо чистых биопрепаратов» ФМБА России

elenavaryush@gmail.comSimbirtsevA SСимбирцевА С

State Scientific Center State Research Institute of Highly Pure Biopreparations

ФГУП «Государственный научно-исследовательский институт особо чистых биопрепаратов» ФМБА России

State Scientific Center State Research Institute of Highly Pure BiopreparationsФГУП «Государственный научно-исследовательский институт особо чистых биопрепаратов» ФМБА России1504201072NO02 (2010)№02 (2010)132210032020Copyright ©; 2009, Pharmarus Print MediaCopyright ©; 2009, Фармарус Принт Медиа2009Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/865

Helicobacter pylori is a Gram-negative bacterium that chronically infects the stomach of more than 50% of human population and represents the major cause of gastroduodenal pathologies. The H. pylori infection is followed by local inflammatory response in gastric mucosa and proinflammatory cytokine production, and preferably elicits a T-helper 1 (Thl) immune response. Bronchial asthma and allergic diseases are orchestrated by Th2 cytokines. A negative association between the H. pylori infection and frequency of allergic diseases was found. Investigations of possible molecular mechanisms of the association are required for research of novel strategies of prevention and treatment of allergic diseases.

Helicobacter pylori - грам-негативная бактерия, которая вызывает хроническую инфекцию более чем у 50% населения и является основной причиной заболеваний желудочно-кишечного тракта. Инфицирование Н. pylori приводит к развитию локального воспалительного ответа в слизистой оболочке желудка и продукции провоспалительных цитокинов, иммунный ответ протекает с преобладанием цитокинов, продуцируемых Т-хелперами 1-го типа (Тh1). При бронхиальной астме и аллергических заболеваниях наблюдают Тh2-опосредованный иммунный ответ. Была найдена негативная ассоциация между наличием инфекции Helicobacter pylori и развитием аллергических заболеваний. Исследования возможных молекулярных механизмов этой ассоциации являются необходимыми для поиска новых стратегий предупреждения и лечения аллергии.

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