Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press85710.36691/RJA857ArticlesСтатьиCathelicidins - antimicrobal peptides and their role in immuno- pathologyКателицидины - антимикробные пептиды: свойства ифункции, роль в иммунопатологииBudikhinaA SБудихинаА С

Institute of immunology

ФГБУ «ГНЦ «Институт иммунологии» ФМБА России

Budikhina@mail.ruPineginВ VПинегинБ В

Institute of immunology

ФГБУ «ГНЦ «Институт иммунологии» ФМБА России

Institute of immunologyФГБУ «ГНЦ «Институт иммунологии» ФМБА России1504201072NO02 (2010)№02 (2010)51210032020Copyright ©; 2009, Pharmarus Print MediaCopyright ©; 2009, Фармарус Принт Медиа2009Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/857

Cathelicidins are a family of cationic amphipathic antimicrobial polypeptides, which play an important role in innate and adaptive immunity. The knowledge of biological effects of these peptides allows to use them not only as an alternative to common antimicrobial therapies. Cathelicidins may also be used for the re-activation of an immune system that has been suppressed by an infection or inflammation, for modulation of inflammation as lipopolysaccharide-binding drugs, and for the activation of regenerative processes. Besides, examination of cathelicidins may serve to detect individuals prone to infectious diseases, to monitor infectious process control in these patients, and to select efficient therapy.

Кателицидины - семейство антимикробных катионных амфипатичных полипептидов. Они играют особую роль во врожденном и адаптивном иммунитете. Знание биологических эффектов кателицидинов позволяет рассматривать их не только в качестве альтернативы широко используемой в настоящее время противоинфекционной терапии. Они могут использоваться для реактивации иммунной системы, подавленной инфекцией и воспалением, для модуляции воспаления как антилипополисахаридные средства, для активации регенеративных процессов. Кроме того, кателицидины могут служить важным критерием для выявления лиц, склонных к инфекционным заболеваниям, для мониторинга инфекционного процесса у этих пациентов и для подбора им эффективной терапии.

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