Russian Journal of AllergyRussian Journal of Allergy1810-88302686-682XFarmarus Print Media80810.36691/RJA808CASE OF A DRESS SYNDROME WITH EOSINOPHILIC PNEUMONIAVorzhevaI I-ChernyakB Abores@angara.ruVorzhevaI IIrkutsk State Institute for Medical Doctors Postgraduate Education-ChernyakB AIrkutsk State Institute for Medical Doctors Postgraduate Education-Irkutsk State Institute for Medical Doctors Postgraduate Education1510201185515310032020Copyright © 1970, Pharmarus Print Media1970The case of the DRESS syndrome developed at the 64 years old patient after carbamazepine intake is reported.
Clinical manifestation of a DRESS syndrome was characterized by a fever, leucocytosis, high eosinophilia of
peripheral blood and sputum, multivisceral involving: skin (maculopapular exanthema), liver (hepatitis), lungs
(eosinophilic pneumonia), lymphadenopathy. Treatment with prednisolone for two months (a starting doze of
60 mg /day) caused full recovery of the patient.DRESS syndromeeosinophilic pneumoniaDRESS-синдромэозинофильная пневмония[Bocquet H., Bagot M., Roujeau J.C. Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS). Semin Cutan Med. Surg. 1996, v. 15, p. 250-257.][Shiohara T., Inaoka M., Kano Y. Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interpla among herpesviruses and antiviral and antidrug immune responses. Allergol. Int. 2006, v. 55, p. 1-8.][Drug hypersensitivity/Editor W. Pichler. Basel: KARGER, 2007, 438 p.][Аллергология и иммунология: национальное руководство. Под ред. Р.М. Хаитова, Н.И. Ильиной. М.,«ГЭОТАР-Медиа». 2009, 656 с.][Walsh S., Creamer D. Drug reaction with eosinophilia and systemic symptoms (DRESS): a clinical update and review of current thinking. Clinical and Experimental Dermatology. 2011, v. 36, Nо. 1, p. 6-11.][Cottin V., Cordier J.F. Eosinophilic pneumonias. Allergy. 2005, v. 60, Nо. 7, p. 841-857.][Воржева И.И. DRESS-синдром как одна из тяжелых форм лекарственной гиперчувствительности. Доктор Ру. 2010, № 2, с. 32-36.][Horsfield P., Deshpande S., Ellis R. Killing with kindness? Drug reaction eosinophilia with systemic symptoms (DRESS) masquerading as acute severe sepsis. J. Antimicrob. Chem. 2009, v. 64, Nо. 6, р. 663-665.]