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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">807</article-id><article-id pub-id-type="doi">10.36691/RJA807</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">Levocetirizine in allergic rhinitis and rhinoconjunctivitis treatment(review)</article-title><trans-title-group xml:lang="ru"><trans-title>Левоцетиризин в терапии аллергического ринита и риноконъюнктивита</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lopatin</surname><given-names>A S</given-names></name><name xml:lang="ru"><surname>Лопатин</surname><given-names>А С</given-names></name></name-alternatives><bio xml:lang="ru"><p>Первый Московский государственный медицинский университет им. И.М. Сеченова</p></bio><email>lopatin@lor.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Latysheva</surname><given-names>E N</given-names></name><name xml:lang="ru"><surname>Латышева</surname><given-names>Е Н</given-names></name></name-alternatives><bio xml:lang="ru"><p>Первый Московский государственный медицинский университет им. И.М. Сеченова</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Lopatin</surname><given-names>A S</given-names></name><bio xml:lang="en"><p>First Moscow State Medical University named after Setchenov, ENT Devision</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Latisheva</surname><given-names>E N</given-names></name><bio xml:lang="en"><p>First Moscow State Medical University named after Setchenov, ENT Devision</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">Первый Московский государственный медицинский университет им. И.М. Сеченова</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">First Moscow State Medical University named after Setchenov, ENT Devision</institution></aff><aff><institution xml:lang="ru"></institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2011</year></pub-date><volume>8</volume><issue>6</issue><issue-title xml:lang="en">NO6 (2011)</issue-title><issue-title xml:lang="ru">№6 (2011)</issue-title><fpage>47</fpage><lpage>52</lpage><history><date date-type="received" iso-8601-date="2020-03-10"><day>10</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1970, Pharmarus Print Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1970, Фармарус Принт Медиа</copyright-statement><copyright-year>1970</copyright-year><copyright-holder xml:lang="en">Pharmarus Print Media</copyright-holder><copyright-holder xml:lang="ru">Фармарус Принт Медиа</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2013-12-15"/></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/807">https://rusalljournal.ru/raj/article/view/807</self-uri><abstract xml:lang="en"><p>This review is devoted to efficacy and safety of levocetirizine in allergic rhinitis treatment. Levocetirize has been
shown to be able to control all symptoms of allergic rhinitis including nasal obstruction, it has anti-inflammatory
and immunomodulatory activity. Levocetirizine has been proven to be safe even in long-term administration
and has less adverse reactions in comparison with other antihistamine drugs. So, levocetirizine is efficacious
and safe medication for treatment patients with mild-to-moderate seasonal and perennial allergic rhinitis and
rhinoconjunctivitis.</p></abstract><trans-abstract xml:lang="ru"><p>В статье приведен обзор клинических исследований эффективности и безопасности левоцетиризина
при лечении аллергического ринита. Левоцетиризин быстро приводит к снижению выраженности всех
симптомов аллергического ринита, улучшает носовое дыхание, обладает противовоспалительной и иммуномодулирующей активностью, безопасен даже при длительном применении, а число нежелательных реакций меньше по сравнению с другими антигистаминными препаратами. Таким образом, левоцетиризин
является эффективным и безопасным средством при лечении пациентов с сезонным и круглогодичным
аллергическим ринитом легкой и средней степени тяжести.</p></trans-abstract><kwd-group xml:lang="en"><kwd>levocetirizine</kwd><kwd>allergic rhinitis</kwd><kwd>antihistaminics</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>левоцетиризин</kwd><kwd>аллергический ринит</kwd><kwd>обратные агонисты Н1-рецепторов</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Sibbald В., Rink E. Epidemiology of seasonal and perennial rhinitis: clinical presentation and medical history. Thorax. 1991, v. 46, p. 895-901.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Katelaris C.H., Lee B W., Potter P. С., Maspero J.F., Cingi C., Lopatin A. et al. Prevalence and diversity of allergic rhinitis in regions ofthe world beyond Europe and North America. Clin. Exp. Allergy. 2011 (в печати).</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Лопатин А.С. Ринит. М., «Литтерра». 2010.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>ARIA. Allergic rhinitis and its impact on asthma. WHO initiative, 2001.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Гущин И.С. Аллергическое воспаление и его фармакологический контроль. М., «Фармарус Принт». 1998, 252 с.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Ciprandi G., Cirillo I., Vizzaccaro A., Tosca M.A. Levocetirizine improves nasal obstruction and modulates cytokine pattern in patients with seasonal allergic rhinitis: a pilot study Clin. Exp. Allergy. 2004, v. 34, p. 958-964.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Ciprandi G., Cirillo I., Vizzaccaro A., Civardi E. et al. Dezloratadine and levocetirizine improve nasal symptoms, airflow, and allergic inflammation in patients with perennialallergic rhinitis: A pilot study. International Immunopharmacology 2005, v. 5, p. 1800-1808.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Mahmound F., Arifhodzic N., Haines D., Novotney L. Levocetirizine modulates lymphocyte activation in patients with allergic rhinitis. J. Pharmacol. Sci. 2008, v. 108, p. 149-156.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Day J.H., Briscoe M.R., Rafeiro E., Ratz J.D. Comparative clinical efficacy, onset and duration of action levocetirizine and dezloratadine for symptoms of seasonal allergic rhinitis in subject evaluated in the Environmental Exposure Unit (EEU). Int. J. Clin. Pract. 2004, v. 58, 2, p. 109-118.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Jorissen M., Bertrand B., Stiels B., Vandenbulcke K. Levocetirizine as treatment for symptoms of seasonal allergic rhinitis. B-ENT 2006, v. 2, p. 55-62.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Canonica G.W., Fumagalli F., Guerra L., Baiardini I. et al. Levocetirizine in persistent allergic rhinitis: continuos or on-demand use? A pilot study. Current medical research and opinion. 2008, v. 24, 10, p. 2829-2839.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Lombardo G., Quattrocchi P., Lombardo G.R., Galati P. et al. Concomitant levocetirizine and montelukast in the treatment of seasonal allergic rhinitis: influence on clinical symptoms. J. Allergy Clin. Immunol. 2006, v. 16, p. 63-68.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Patel P., Patel D. Efficacy comparison of levocetirizine vs montelucast in ragweed sensitized patients. Ann. Allergy Asthma Immunol. 2008, v. 101, p. 287-294.</mixed-citation></ref></ref-list></back></article>
