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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="other" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">787</article-id><article-id pub-id-type="doi">10.36691/RJA787</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject></subject></subj-group></article-categories><title-group><article-title xml:lang="en">SIGNIFICANCE OF FILAGGRIN IN DEVELOPMENT OF ATOPICDERMATITIS</article-title><trans-title-group xml:lang="ru"><trans-title>ЗНАЧЕНИЕ ФИЛАГГРИНА В РАЗВИТИИАТОПИЧЕСКОГО ДЕРМАТИТА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Varlamov</surname><given-names>E E</given-names></name><name xml:lang="ru"><surname>Варламов</surname><given-names>Е Е</given-names></name></name-alternatives><bio xml:lang="ru"><p>ФГ У «Московский научно-исследовательский институт педиатрии и детской хирургииМинздравсоцразвития Р оссии»</p></bio><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pampura</surname><given-names>A N</given-names></name><name xml:lang="ru"><surname>Пампура</surname><given-names>А Н</given-names></name></name-alternatives><bio xml:lang="ru"><p>ФГ У «Московский научно-исследовательский институт педиатрии и детской хирургииМинздравсоцразвития Р оссии»</p></bio><email>apampura@pedklin.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name><surname>Varlamov</surname><given-names>E E</given-names></name><bio xml:lang="en"><p>Moscow Research Institute of Pediatric and Child Surgery</p></bio><xref ref-type="aff" rid="aff2"/></contrib><contrib contrib-type="author"><name><surname>Pampura</surname><given-names>A N</given-names></name><bio xml:lang="en"><p>Moscow Research Institute of Pediatric and Child Surgery</p></bio><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en"></institution></aff><aff><institution xml:lang="ru">ФГ У «Московский научно-исследовательский институт педиатрии и детской хирургииМинздравсоцразвития Р оссии»</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Moscow Research Institute of Pediatric and Child Surgery</institution></aff><aff><institution xml:lang="ru"></institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2011-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2011</year></pub-date><volume>8</volume><issue>5</issue><issue-title xml:lang="en">NO5 (2011)</issue-title><issue-title xml:lang="ru">№5 (2011)</issue-title><fpage>26</fpage><lpage>30</lpage><history><date date-type="received" iso-8601-date="2020-03-10"><day>10</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 1970, Pharmarus Print Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 1970, Фармарус Принт Медиа</copyright-statement><copyright-year>1970</copyright-year><copyright-holder xml:lang="en">Pharmarus Print Media</copyright-holder><copyright-holder xml:lang="ru">Фармарус Принт Медиа</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2013-10-15"/></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/787">https://rusalljournal.ru/raj/article/view/787</self-uri><abstract xml:lang="en"><p>In presented article modern data about relationship of filaggrin mutation with development and clinic
manifestation of atopic dermatitis are summarized.</p></abstract><trans-abstract xml:lang="ru"><p>В представленной статье обобщены современные данные о взаимосвязи мутаций филаггрина с развитием
и клиническими проявлениями атопического дерматита.</p></trans-abstract><kwd-group xml:lang="en"><kwd>atopic dermatitis</kwd><kwd>filaggrin</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>атопический дерматит</kwd><kwd>филаггрин</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Bieber Т., Leung D. Atopic dermatitis. 2002, New York: Marcel Dekker.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Elias P.M., Wood L.C., Feingold K.R. Epidermal pathogenesis of inflammatory dermatoses. Am. J. Contact Dermatol. 1999, v. 10, p. 119-126.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Taieb A. Hypothesis: from epidermalbarrier dysfunction to atopic disorders. Contact Dermatitis. 1999, v. 41, p. 177-180.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Lavker R.M., Matoltsy A.G. 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