Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press76810.36691/RJA768ArticlesСтатьиOsobennosti sekretornogo immunitetazheludochno-kishechnogo traktaОсобенности секреторного иммунитетажелудочно-кишечного трактаAgafonovViktor Evgen'evichАгафоновВиктор Евгеньевич

НИИ вакцин и сывороток им. И.И. Мечникова РАМН, г. Москва

agafonov-ve@yandex.ruIl'intsevaN VИльинцеваН В

НИИ вакцин и сывороток им. И.И. Мечникова РАМН, г. Москва

GervazievaV BГервазиеваВ Б

НИИ вакцин и сывороток им. И.И. Мечникова РАМН, г. Москва

НИИ вакцин и сывороток им. И.И. Мечникова РАМН, г. Москва1502201181NO1 (2011)№1 (2011)142410032020Copyright ©; 2011, Pharmarus Print MediaCopyright ©; 2011, Фармарус Принт Медиа2011Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/768

В обзоре описаны структура и функции слизистой оболочки желудочно-кишечного тракта (ЖКТ), основные компоненты слизистого барьера, включая иммуноглобулины, муцины и антимикробные пептиды. Отмечена роль комменсальной микрофлоры. Рассмотрена структура лимфоидной ткани кишечника (GALT), ее основные клеточные элементы, осуществляющие надзор врожденного иммунитета за гомеостазом в слизистой оболочке ЖКТ и контролирующие оральную толерантность. Представлены иммунорегуляторы адоптивного иммунного ответа (Th1, Th2 и Th17), ответственные за срыв толерантности, развитие пищевой аллергии, аутоиммунитета и хронического воспаления кишечника.

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