Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press73110.36691/RJA731ArticlesСтатьиResearch ArticleFEATURES OF THE CYTOKINE PROFILE IN INFANTS WITH MULTIPLE FOOD PROTEIN INTOLERANCEОСОБЕННОСТИ ЦИТОКИНОВОГО ПРОФИЛЯ У ДЕТЕЙ РАННЕГО ВОЗРАСТА С МНОЖЕСТВЕННОЙ НЕПЕРЕНОСИМОСТЬЮ ПИЩЕВЫХ БЕЛКОВVarlamovE EВарламовЕ Еvarlamov80@mail.ruVinogradovaT VВиноградоваТ ВChuslyaevaA AЧусляеваА АPampuraA NПампураА НFederal State Institution «Moscow Research Institute of Pediatrics and Child Surgery» by Ministry of Health and Social Welfare of RussiaФГБУ «Московский научно-исследовательский институт педиатрии и детской хирургии» Министерства здравоохранения России1510201295NO5 (2012)№5 (2012)768010032020Copyright ©; 2012, Pharmarus Print MediaCopyright ©; 2012, Фармарус Принт Медиа2012Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/731

Introduction. Types of the course of allergic diseases may be related to cytokine profile. Determination of the spectrum of cytokines to evaluate the mechanisms of allergic inflammatory process that improves the efficiency of management of patients with allergic diseases was performed. Background. To establish the features of cytokine profile in children with multiple food protein intolerance. Methods. 39 children with atopic dermatitis and food allergy were included in the openlabel study, 18 of whom had multiple food protein intolerance. All patients were examined with enzyme immunoassay (ELISA) to determine the concentration of IL-4, IL-5, IL-13, IL-17, IL-22, eotaxin, eotaxin2, TGF-β. Results. In children with multiple food protein intolerance the concentration of TGF-β was increased in comparison with the group of children without multiple food intolerances Me 14,04 [11,3; 18,0] against 10,3 [4,8; 12, 8] pg/ml, respectively, p = 0,038. The level of other cytokines had no difference. Conclusion. Increased concentration of TGF-β in patients with multiple food protein intolerance may be an additional indication for the amino acid formulas.

Цель. Установить особенности цитокинового профиля у детей с множественной непереносимостью пищевых белков. Материалы и методы. В открытое исследование включены 39 детей с сочетанием атопического дерматита и пищевой аллергией, из них у 18 пациентов отмечалась множественная непереносимость пищевых белков. всем пациентам методом иммуноферментного анализа (ELISA) проводилось определение концентрации ИЛ-4, ИЛ-5, ИЛ-13, ИЛ-17, ИЛ-22, эотаксина, эотаксина-2, TGF-ß. Результаты. У детей с множественной непереносимостью пищевых белков отмечалось повышение концентрации TGF-β в сравнении с группой детей без множественной пищевой непереносимости (Ме — 14,04 [11,3; 18,0] против 10,3 [4,8; 12,8] пг/мл соответственно, р=0,038). По уровню других цитокинов группы пациентов не различались. Заключение. Повышенная концентрация TGF-β у пациентов с множественной непереносимостью пищевых белков может служить дополнительным показанием для назначения аминокислотных смесей.

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