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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">713</article-id><article-id pub-id-type="doi">10.36691/RJA713</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">SEVERE ASTHMA: PHENOTYPES AND ROLE OF SMALL AIRWAYS</article-title><trans-title-group xml:lang="ru"><trans-title>ТЯЖЕЛАЯ БРОНХИАЛЬНАЯ АСТМА: ФЕНОТИПЫ И РОЛЬ МАЛЫХ ДЫХАТЕЛЬНЫХ ПУТЕЙ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fassakhov</surname><given-names>R S</given-names></name><name xml:lang="ru"><surname>Фассахов</surname><given-names>Р С</given-names></name></name-alternatives><email>farrus@mail.ru</email><xref ref-type="aff" rid="aff1"/><xref ref-type="aff" rid="aff2"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Kazan Research institute of Epidemiology and Microbiology of Rospotrebnadzor</institution></aff><aff><institution xml:lang="ru">ФБУН Казанский НИИ Роспотребнадзора</institution></aff></aff-alternatives><aff-alternatives id="aff2"><aff><institution xml:lang="en">Kazan State Medical Academy</institution></aff><aff><institution xml:lang="ru">ФБОУ ДПО Казанская государственная медицинская академия</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2012-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2012</year></pub-date><volume>9</volume><issue>6</issue><issue-title xml:lang="en">NO6 (2012)</issue-title><issue-title xml:lang="ru">№6 (2012)</issue-title><fpage>49</fpage><lpage>54</lpage><history><date date-type="received" iso-8601-date="2020-03-10"><day>10</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2012, Pharmarus Print Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2012, Фармарус Принт Медиа</copyright-statement><copyright-year>2012</copyright-year><copyright-holder xml:lang="en">Pharmarus Print Media</copyright-holder><copyright-holder xml:lang="ru">Фармарус Принт Медиа</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2014-12-15"/></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/713">https://rusalljournal.ru/raj/article/view/713</self-uri><abstract xml:lang="en"><p>The role of small airways in severe asthma is discussed. The involvement of small airways in the inflammatory process increases the importance of the value delivery systems for effective anti-inflammatory therapy. Extrafine aerosol beclomethasone dipropionate / formoterol (Foster) delivers the drug in the small bronchi significantly improving patient outcomes.</p></abstract><trans-abstract xml:lang="ru"><p>Обсуждается роль малых дыхательных путей при тяжелой бронхиальной астме. Вовлечение бронхов малого калибра в воспалительный процесс увеличивает значимость систем доставки для эффективной противовоспалительной терапии. Экстрамелкодисперсный аэрозоль беклометазона дипропионата/формотерола (фостер) обеспечивает доставку препарата в мелкие бронхи, значительно улучшая результаты лечения. Последние десятилетия ознаменовались существенным прорывом в терапии бронхиальной астмы (БА). Уточнение механизмов хронического воспаления в патогенезе заболевания вместе с появлением высокоэффективных средств терапии позволили разработать клинические рекомендации и терапевтические подходы, которые не только существенно снизили смертность от БА, но и привели к уменьшению количества госпитализаций, вызванных обострением болезни, и существенно повысили качество жизни больных даже с тяжелыми формами заболевания. Эти успехи во многом связаны с широким использованием в качестве противовоспалительных препаратов современных ингаляционных глюкокортикостероидов (ИГКС), назначаемых при необходимости в комбинации с длительно действующими ßj-агонистами (ДДБА). Применение ИГКС и комбинаций ИГКС/ДДБА на основе ступенчатого подхода позволяет подобрать и проводить такую фармакотерапию заболевания, которая позволяет добиться контролируемого течения БА в кратчайшие сроки и поддерживать его на оптимальном уровне.</p></trans-abstract><kwd-group xml:lang="en"><kwd>bronchial asthma</kwd><kwd>small airways</kwd><kwd>extrafine aerosol</kwd><kwd>Foster</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>бронхиальная астма</kwd><kwd>малые дыхательные пути</kwd><kwd>экстрамелкодисперсный аэрозоль</kwd><kwd>фостер</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>W Busse. Difficult to treat asthma: how serious is the problem and what the issues? Difficult-to-Treat Severe Asthma Edited by K.F. Chung, E.H. Bel and S.E. Wenzel. European Respiratory Society Monograph. 2011, v 51, p. 1-15.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Li X., Howard T.D., Ampleford E.J. et al. 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