Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press69610.36691/RJA696ArticlesСтатьиResearch ArticleTACROLIMUS IN TREATMENT OF ATOPIC DERMATITIS PATIENTS WITH SIDE EFFECTS OF LONG LASTING TOPICAL CORTICOSTEROIDS APPLICATION. CASE REPORTSПрименение такролимуса у больных атопическим дерматитом с осложнениями вследствие длительного использования топических глюкокортикостероидов. Клинические случаиElisyutinaO GЕлисютинаОльга Гурьевнаel-olga@yandex.ruFedenkoE SФеденкоЕ СShtirbulO VШтырбулО ВФГБУ «ГНЦ институт иммунологии» ФМБА России1512201296NO6 (2012)№6 (2012)323810032020Copyright ©; 2012, Pharmarus Print MediaCopyright ©; 2012, Фармарус Принт Медиа2012Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/696

The own data of the retrospective analysis of 88 atopic dermatitis (AD) clinical cases from 2011 to 2012 are presented in this article. 3 clinical cases of tacrolimus using in AD patients, who had side effects of long lasting topical corticosteroids application are described.

В статье приведены собственные данные ретроспективного анализа 88 историй болезни пациентов с атопическим дерматитом (АтД) за период с 2011 по 2012 год, представлены 3 клинических случая применения такролимуса у больных АтД с осложнениями вследствие длительного использования топических глюкокортикостреоидов (тгкс).

atopic dermatitistacrolimuscalcineurin inhibitorsатопический дерматиттакролимусингибиторы кальциневринаАллергология и иммунология: национальное руководство. Под ред. Р.М. Хаитова, Н.И. Ильиной. М., «ГЭОТАР-Медиа». 2009, 656 с.Akdis C.A. Review article Diagnosis and treatment of atopic dermatitis in children and adults: Europian Academy of Allergology and Clinical Immunology. American Academy of Allergy, Asthma and Immunology. PRACTALL Consensus report. Allergy. 2006, v. 61, p. 969-987.Hengge U.R., Ruzicka T, Schwartz R.A., Cork M.J. Adverse effects of topical glucocorticosteroids. J. Am. Acad. Dermatol. 2006, v. 54 (1), p. 1-15.Liu J., Farmer J.D. Jr., Lane W.S. et al. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell. 1991, v. 66, p. 807-815.Ashcroft D.M., Chen L.C., Garside R. et al. Topical pimecro-limus for eczema. Cochrane Database of Systematic Reviews. 2007, Issue 4.Hebert A.A. Review of pimecrolimus cream 1% for the treatment of mild to moderate atopic dermatitis. Department of Dermatology, The University of Texas Health Science Center, Houston, Texas 77030, USA.Sheng-Li Chen. Two topical calcineurin inhibitors for the treatment of atopic dermatitis in pediatric patients: A metaanalysis of randomized clinical trials. Journal of Dermatological Treatment. 2010, v. 21, p. 144-156.Reitamo S. et al. Treatment with twice-weekly tacrolimus ointment in patients with moderate to severe atopic dermatitis: results from two randomized, multicentre, comparative studies. Journal of Dermatological Treatment. 2010, v. 21, p. 34-44.Kyllonen H., Remitz A., Mandelin J.M. et al. Effects of 1-year intermittend treatment with topical tacrolimus monotherapy on skin collagen synthesis in patient with atopic dermatitis. Br. J. of Dermatology. 2004, v. 150, p. 1174-1181.Hanifin J.M., Rajka G. Diagnostic features of atopic dermatitis. Acta Derm. Venerol. 1980, v. 92, p. 44-47.Europian Task Force on Atopic Dermatitis. Severity scoring of atopic dermatitis: the SCORAD index. Dermatology. 1993, v. 186, p. 23-31.