Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press64410.36691/RJA644ArticlesСтатьиResearch ArticleEpidermal barrier disfunction correction in atopic dermatitis patientsНарушение барьерной функции кожи и ее коррекция у больных атопическим дерматитомShvetsS MШвецС Мsmshvets@gmail.comElisyutinaO GЕлисютинаО ГInstitute of ImmunologyФГБУ «ГНЦ Институт иммунологии» ФМБА России15062013103NO3 (2013)№3 (2013)576010032020Copyright ©; 2013, Pharmarus Print MediaCopyright ©; 2013, Фармарус Принт Медиа2013Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/644

In the article data about epidermal barrier disfunction in atopic dermatitis patients and modern approaches to their correction with use of modern skin-care products are submitted.

В статье представлены данные о нарушениях функции эпидермального барьера у больных атопическим дерматитом и подходы к их коррекции с использованием современных средств по уходу за кожей.

atopic dermatitisepidermal barrierskin-care productsатопический дерматитэпидермальный барьерсредства по уходу за кожейГущин И.С. Эпидермальный барьер и аллергия. Росс. Аллергол. Журн. 2007, № 2, с. 3-16.Bouwstra J.A., Ponec M. The skinbarrier in healthy and diseased state. Biochim. Biophys Acta. 2006, v. 1753, p. 2080-2095.Ohman H., Vahlquist A. In vivo studies concerning a pH gradient in human stratum corneum and upper epidermis. Acta Derm. Venereol. 1994, v. 74, p. 375-379.Brown S.J., Irvine A.D. Atopic eczema and the filaggrin story. Semin. Cutan. Med. Surg. 2008, v. 27, p. 128-137.Weidinger S., Illig T., Baurecht H. et al. Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations. J. Allergy Clin. Immunol. 2006, v. 118, p. 214-219.Smith F.J., Irvine A.D., Terron-Kwiatkowski A. et al. Loss-of-function mutations in the gene encording filaggrin cause ichthyosis vulgaris. Nat. Genet. 2006, v. 38, p. 337-342.Scharschmidt T.C., Man M.Q., Hatano Y. et al. Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens. J. Allergy Clin. Immunol. 2009, v. 124, p. 496-506.Choi M.J., Maibach H.I. Role of ceramides in barrier function of healthy and diseased skin. Am. J. Clin. Dermatol. 2005, v. 6, p. 215-223.Elias P.M., Schmuth M. Abnormal skin barrier in the etiopathogenesis of atopic dermatitis. Curr. Opin Allergy Clin. Immunol. 2009, v. 9 (5), p. 437-446.Lomholt H., Andersen K.E., Kilian M. Staphylococcus aureus clonal dynamics and virulence factors in children with atopic dermatitis. J. Invest. Dermatol. 2005, v. 125, p. 977-982.Baker B.S. The role of microorganisms in atopic dermatitis. Clin. Exp. Immunol. 2006, v. 144, p. 1-9.Vicedo-Cabrera A.M., Garcia-Marcos L., Llopis-Gonzalez A. et al. Atopic dermatitis and indoor use of energy sources in cooking and heating appliances. BMC Public. Health. 2012, v. 22, 12:890. doi: 10.1186/1471-2458-12-890.Garg A., Chren M.M., Sands I.P et al. Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stress-associated skin disorders. Arch. Dermatol. 2001, v. 137, p. 377-382.Akdis C.A. Review article Diagnosis and treatment of atopic dermatitis in children and adults: Europеan Academy of Allergology and Clinical Immunology. American Academy of Allergy, Asthma and Immunology. PRACTALL Consensus report. Allergy. 2006, v. 61, p. 969-987.Matta А.М., Lefeuvre L., Tindel M. et al. Сборник статей Laboratoires Dermatologiques d’Uriage (Courbevoie-France), 2008, 118 с.