<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">639</article-id><article-id pub-id-type="doi">10.36691/RJA639</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">THERAPEUTIC EFFICACY OF A POLY-FUNCTIONAL ANTIALLERGIC DRUG - RUPATADINE</article-title><trans-title-group xml:lang="ru"><trans-title>ЛЕЧЕБНАЯ ЭФФЕКТИВНОСТЬ ПОЛИФУНКЦИОНАЛЬНОГО ПРОТИВОАЛЛЕРГИЧЕСКОГО ПРЕПАРАТА - РУПАТАДИНА</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gushchin</surname><given-names>I S</given-names></name><name xml:lang="ru"><surname>Гущин</surname><given-names>Игорь Сергеевич</given-names></name></name-alternatives><email>igushchin@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Institute of Immunology</institution></aff><aff><institution xml:lang="ru">ФГБУ «ГНЦ Институт иммунологии» ФМБА России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2013</year></pub-date><volume>10</volume><issue>1</issue><issue-title xml:lang="en">NO1 (2013)</issue-title><issue-title xml:lang="ru">№1 (2013)</issue-title><fpage>63</fpage><lpage>77</lpage><history><date date-type="received" iso-8601-date="2020-03-10"><day>10</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, Pharmarus Print Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, Фармарус Принт Медиа</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">Pharmarus Print Media</copyright-holder><copyright-holder xml:lang="ru">Фармарус Принт Медиа</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2015-12-15"/></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/639">https://rusalljournal.ru/raj/article/view/639</self-uri><abstract xml:lang="en"><p>Rupatadine is a new poly-functional agent (selective histamine H 1-receptor and PAF-receptor antagonist with additional anti-inflammatory potency) for the management of patients with allergic rhinitis and chronic urticaria. It has a rapid onset of action, and its long-lasting effect permits once-daily dosing. It has been shown that rupatadine is effective, well-tolerated and safe in relieving symptoms in patients with seasonal and perennial/ intermittent and persistent allergic rhinitis and chronic urticaria.</p></abstract><trans-abstract xml:lang="ru"><p>Рупатадин — новое полифункциональное лекарственное средство (избирательный антагонист гистаминовых Н 1-рецепторов и PAF-рецепторов с дополнительной противовоспалительной активностью) для лечения аллергического ринита и хронической крапивницы. Рупатадин обладает быстро наступающим действием, а его продолжительный эффект позволяет использовать препарат один раз в сутки. Установлено, что использование рупатадина является эффективным, хорошо переносимым и безопасным методом лечения сезонного и круглогодичного/интермиттирующего и персистирующего аллергического ринита и хронической идиопатической крапивницы.</p></trans-abstract><kwd-group xml:lang="en"><kwd>IgE-mediated allergy</kwd><kwd>H -receptor antagonists</kwd><kwd>PAF-receptor antagonists</kwd><kwd>allergic rhinitis</kwd><kwd>chronic urticaria</kwd><kwd>rupatadine</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>IgE-опосредованная аллергия</kwd><kwd>антагонисты Н -рецепторов</kwd><kwd>антагонисты PAF-рецепторов</kwd><kwd>аллергический ринит</kwd><kwd>хроническая крапивница</kwd><kwd>рупатадин</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Адо А.Д. Общая аллергология. М., «Медицина». 1978, 463 с.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Гущин И.С. Аллергическое воспаление и его фармакологический контроль. М., «Фармарус Принт». 1998, 252 с.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Ferstl R., Akdis C.A., O’Mahony L. Histamine regulation of innate and adaptive immunity. Front. Biosci. 2012, v. 17, p. 40-53.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Гущин И.С. Полифункциональная противоаллергическая активность антигистаминного препарата рупатадина. Рос. Аллергол. Журн. 2012, № 4, с. 3-12.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Curtin M.L. Current status of platelet-activating factor antagonists. Exp. Opin. Ther. Patents. 1998, v. 8, p. 703-711.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Mullol J., Bousquet J., Bachert C. et al. Rupatadine in allergic rhinitis and chronic urticaria. Allergy. 2008, v. 63 (Suppl. 87), p. 5-28.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Bousquet J., van Couwenberg P., Khaltaev N. and WHO Panel. Allergic rhinitis and its impact on asthma. ARIA. In collaboration with the World Health Organization. J. Allergy Clin. Immunol. 2001, v. 108, p. S1-S315.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Ciprandi G., Cirillo I., Vizzacaro A. et al. Seasonal and perennial allergic rhinitis: is this classification adherent to real life. Allergy. 2005, v. 60, p. 882-887.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Demoly P., Allaert F.A., Lecasable M. et al. Validation of the classification of ARIA (allergic rhinitis and its impact on asthma). Allergy. 2003, v. 58, p. 672-675.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Данилычева И.В. Крапивница. В кн.: Аллергология и иммунология: национальное руководство. Под ред. Р.М. Хаитова, Н.И. Ильиной. М., «ГЭОТАР-Медиа». 2009, с. 461-472.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Zuberbier T., Bindslev-Jensen C., Canonica W. et al. EAACI/ GA2LEN/EDF guideline: definition, classification and diagnosis of urticaria. Allergy. 2006, v. 61, p. 316-320.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Katiyar S., Prakash S. Pharmacological profile, efficacy and safety of rupatadine in allergic rhinitis. Primary Care Respiratory Journal. 2009, v. 18, p. 57-68.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Isquierdo I., Merlos M., Garcia-Rafanell J. Rupatadine, a new selective histamine H1-receptor and platelet-activating factor (PAF) antagonist: a review of pharmacological profile and clinical management of allergic rhinitis. Drugs Today. 2003, v. 39, p. 451-468.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Picado C. Rupatadine: pharmacological profile and its use in the treatment of allergic disorders. Expert Opin. Pharmacother. 2006, v. 7, p. 1089-2001.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Keam S.J., Plosker G.L. Rupatadine: a review of its use in the management of allergic disorders. Drugs. 2007, v. 67, p. 457-474.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Mion O., Campos R.A., Antilla M. et al. Futura study — Evaluation of efficacy and safety of rupatadine fumarate in the treatment of persistent allergic rhinitis. Braz. J. Otorhinolaryngol. 2009, v. 75, p. 673-679.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Ciprandi G., Cirillo I. Rupatadine improves nasal symptoms, airflow and inflammation in patients with persistent allergic rhinitis: a pilot study. J. Biol. Regul. Homeostat. Agents. 2010, v. 24, p. 177-183.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Valero A., Isquierdo I., Giralt J. et al. Rupatadine improves nasal symptoms, quality of life (ESPRINT-15) and severity in subanalysis of cohort of spanish allergy rhinitis patients. J. Investig. Allergol. Clin. Immunol. 2011, v. 21, p. 229-235.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>De Pita O., Giani M., Frezzolini A. et al. Rupatadine in treatment of chronic urticaria. Allergy. 2011, v. 66 (Suppl. 94), p. 273.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Izquierdo I., Cranswick N., McCreanor J. et al. Rupatadine in children aged 6-11 years with allergic rhinitis: a proof of concept evaluation by a 4 weeks treatment follow-up study. Rupatadine oral solution, in children age 6-11 years with allergic rhinitis: a proof of concept evaluation and 4 weeks treatment follow-up efficacy and safety study. J. Compilation. 2009, v. 20 (Suppl. 20), p. 2.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Saint-Martin F., Dumur J.P., Perez I. et al. A randomized, double-blind, parallel-group study, comparing the efficacy and safety of rupatadine (20 and 10 mg), a new PAF and H1 receptor specific histamine antagonist, to loratadine 10 mg in the treatment of seasonal allergic rhinitis. J. Invest. Allergol. Clin. Immunol. 2004, v. 14, p. 34-40.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Potter P., Maspero J., Vermeulen J. et al. Rupatadine improves nasal symptoms control at 4 and 6 weeks in children with persistent allergic rhinitis. Allergy. 2011, v. 66 (Suppl. 94), p. 11.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Stuebner P., Horak F., Zieglmayer R. et al. Effects of rupatadine vs placebo on allergen induced symptoms in patients exposed to aeroallergens in Vienna Challenge Chamber. Ann. Allergy Asthma Immunol. 2006, v. 96, p. 37-44.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Valero F., Serrano C., Bartra J. et al. Reduction of nasal volume after allergen-induced rhinitis in patients treated with rupatadine: a randomized, cross-over, double-blind, placebo-controlled study. J. Investig. Allergol. Clin. Immunol. 2009, v. 19, p. 488-493.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Izquierdo I., Paredes I., Lurigardos C. et al. A dose ranging study of rupatadine fumarate in patients with seasonal allergic rhinitis. Allergy. 2000, v. 55 (Suppl. 63), p. 275.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Perez I., De la Cruz G., Villa M., Izquierdo I. Rupatadine in allergic rhinitis: pooled analysis of efficacy data. Allergy. 2002, v. 57 (Suppl. 73), p. 245.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Izquierdo I., Paredes I., Lurigados C. et al. A dose ranging study of rupatadine fumarate in patients with seasonal allergic rhinitis. Allergy. 2011, v. 66 (Suppl. 94), p. 275.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Martinez-Cocera C., De Molina M., Marti-Guadano E. et al. Rupatadine 10 mg and cetirizine 10 mg in seasonal allergic rhinitis: a randomized, double-blind parallel study. J. Invest. Allergol. Clin. Immunol. 2005, v. 15, p. 22-29.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Guadano E.M., Serra-Batlles J., Meseguer J. et al. Rupatadine 10 mg and ebastine 10 mg in seasonal allergic rhinitis. Allergy. 2004, v. 59, p. 766-771.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Maiti R., Rahman J., Jaida J. et al. Rupatadine and levocetirizine for seasonal allergic rhinitis. A comparative study of efficacy and safety. Arch. Otolaryngol. Head Neck Surg. 2010, v. 136, p. 796-800.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Kowalski M., Jurkewitcz D., Kruszewski J. et al. Rupatadine 10 and 20 mg are effective in the treatment of perennial allergic rhinitis after 4 weeks of treatment: a randomized, double-blind, controlled trial with loratadine and placebo. Therapy. 2009, v. 6, p. 417-425.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Molina M., Pinto E., Cistero A. et al. Rupatadine 10 mg in adolescent and adult symptom relief of perennial allergic rhinitis. Therapy. 2010, v. 7, p. 429-436.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Marmouz F., Giralt J., Izquierdo I. et al. Morning and evening efficacy evaluation of rupatadine (10 and 20 mg), compared with cetirizine 10 mg in perennial allergic rhinitis: a randomized, double blind, placebo-controlled trial. J. Asthma Allergy. 2011, v. 4, p. 27-35.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Fantin S., Maspero J., Bisbal C. et al. A 12-week placebo-controlled study of rupatadine 10 mg once daily compared with cetirizine 10 mg once daily, in the treatment of persistent allergic rhinitis. Allergy. 2008, v. 63, p. 924-931.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Potter P., Maspero J., Vermeulen J. et al. Rupatadine improves nasal symptoms control at 4 and 6 weeks in children with persistent allergic rhinitis. Allergy. 2011, v. 66 (Suppl. 94), p. 11-12.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Gimenez-Arnau A., Pujol R.M., Ianosi S. et al. Rupatadine in the treatment of chronic urticaria: a double-blind, randomized, placebo-controlled multicenter study. Allergy. 2007, v. 62, p. 539-546.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Dubertret L., Zalupca L., Cristodoulo T. et al. Once-daily rupatadine improves the symptoms of chronic idiopathic urticaria: a randomized, double-blind, placebo-controlled study. Eur. J. Dermatol. 2007, v. 17, p. 223-228.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Gimenez-Arnau A., Perez I., Donado E. et al. Fast onset of action of rupatadine in the reduction of pruritus in patients suffering from chronic urticaria: pooled analysis. Allergy. 2007, v. 62 (Suppl. 83), p. 306.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Gimenez-Arnau A., Izquierdo I., Mauer M. The use of a responder analysis to identify clinically meaningful differences in chronic urticaria patients following placebo-controlled treatment with rupatadine 10 and 20 mg. J. Eur. Acad. Dermatol. Venerol. 2009, v. 23, p. 1088-1091.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Metz M., Scholz E., Ferran M. et al. Rupatadine and its effects on symptom control, stimulation time, and temperature thresholds in patients with acquired cold urticaria. Ann. Allergy Asthma Immunol. 2010, v. 104, p. 86-92.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Karppinen A., Brummer-Korvenkontio H., Reunala T., Izquierdo I. Rupatadine 10 mg in the treatment of immediate mosquito-bite allergy. J. Eur. Acad. Dermatol. Venerol. 2012, v. 26, p. 919-922.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Valero A., de la Torre F., Castillo J.A. et al. Safety of rupatadine administered over a period of 1 year in the treatment of persistent allergic rhinitis. Drug Safety. 2009, v. 32, p. 33-42.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Solans A., Li Carbo M., Pena J. et al. Influence of food on the oral bioavailability of rupatadine tablets in healthy volunteers: a single-dose, randomized, open-label, two-way crossover study. Clin. Therapeutics. 2007, v. 29, p. 900-908.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Гущин И.С. Кардиотоксическое действие антагонистов Н1-гистаминовых рецепторов. Клинич. фармакол. и терапия. 1998, № 3, с. 82-86.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Ramis I., Giral M., Nieto C. et al. Lack of cardiotoxic effects of rupatadine in isolated Purkinje fibres and its relationship with rupatadine cardiac level. Allergy. 2000, v. 55 (Suppl. 63), p. 264.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Giral M., Merlos M., Balsa D. et al. Effects of rupatadine on cardiovascular profile in rats and guinea pigs: comparison with other nonsedating antihistamines. Allergy. 1997, v. 52 (Suppl. 37), p. 44-45.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Izquierdo I., Perez I., Villa M. et al. Lack of electrocardiographic effects of rupatadine, new nonsedating selective histamine H1-receptor and PAF antagonist. Allergy. 2001, v. 56 (Suppl. 68), p. 212.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Caballero R., Valenzuela C., Longobardo M. et al. Effects of rupatadine, a new dual antagonist of histamine and platelet-activating factor receptors, on human cardiac Kv1. 5 Br. J. Pharmacol. 1999, v. 128, p. 1071-1081.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Donado E., Izquierdo I., Perez I. et al. No cardiac effects of therapeutic and supratherapeutic doses of rupatadine: results from a «thorough QT/QTc study» performed according to ICH guidelines. Br. J. Clin. Pharmacol. 2010, v. 69, p. 401-410.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Carvajal A., Macias D., Salado I. et al. Heart rhythm disturbances associated with rupatadine: a case series from the Spanish and Portuguese Pharmacovigilance System. Clin. Pharmacol. Therap. 2009, v. 85, p. 481-484.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Nombela-Franco L., Ruiz-Antoran B., Toquero-Ramos J., Silva-Melchor L. Torsado de pointes associated with rupatadine. Rev. Esp. Cardiol. 2008, v. 61, p. 328-329.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Fite R., Borja J. Rupatadine and heart rhythm disturbances. Clin. Pharmacol. Therap. 2010, v. 87, p. 37.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Barbanoj M.J., Garcia-Gea C., Morte A. et al. Central and peripheral evaluation of rupatadine, a new antihistamine/ platelet-activating factor antagonist, at different doses in healthy volunteers. Neuropsychobiology. 2004, v. 50, p. 311-321.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Barbanoj M.J., Garcia-Gea C., Antoniajoan R. et al. Evaluation of the cognitive, psychomotor and pharmacokinetic profiles of rupatadine, hydroxyzine and cetirizine, in combination with alcohol, in healthy volunteers. Hum. Psychopharmacol. Clin. Exp. 2006, v. 21, p. 13-26.</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Garcia-Gea C., Ballester M.R., Martinez J. et al. Rupatadine does not potentiate the CNS depressant effects of lorazepam: randomized, double-blind, crossover, repeated dose, placebo-controlled study. Brit. J. Clin. Pharmacol. 2010, v. 69, p. 663-674.</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Vuurman E., Theunissen E., van Oers A. et al. Lack of effects between rupatadine 10 mg and placebo on actual driving performance of healthy volunteers. Hum. Psychopharmacol.</mixed-citation></ref></ref-list></back></article>
