Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press59810.36691/RJA598ArticlesСтатьиReview ArticleExpired air nitric oxide in patients with bronchial asthma and chronic obstructive pulmonary disease with different disease courseОксид азота в выдыхаемом воздухе у больных бронхиальной астмой и хронической обструктивной болезнью легких в зависимости от особенностей течения заболеванияFedoseevG BФедосеевГ Бfedoseevsp@mail.ruTrofimovV IТрофимовВ ИTimchikV GТимчикВ ГNegrutsaK VНегруцаК ВRazumovskayaT SРазумовскаяТ СRogachovaN NРогачеваН НAlexandrinV AАлександринВ АKriakunovK NКрякуновК НSaint Petersburg Pavlov State Medical UniversityГБОУ ВПО Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова15042013102NO2 (2013)№2 (2013)121810032020Copyright ©; 2013, Pharmarus Print MediaCopyright ©; 2013, Фармарус Принт Медиа2013Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/598

Expired air nitric oxide was measured in 113 subjects (26 healthy controls, 64 bronchial asthma (BA) patients and 23 COPD patients. In BA patients 10 had mild course of the disease. In 50 the course was estimated as moderate, 4 patients had severe course of the disease. In 20 patients BA was associated with COPD. The results revealed the dependence of FeNO on following factors: severity of the disease: in severe and moderate BA course FeNO was significantly higher than in mild BA; on phase of the disease: in exacerbation FeNO was significantly higher than in remission; on control of the disease: in patients, in whom it was difficult to reach the disease control, FeNO was higher than in others. In COPD patients FeNO was significantly lower than in BA ones. Even in subjects with marked airways inflammation manifested by high sputum cellularity FeNO was low.

Приведен обзор литературных данных и собственные материалы исследования содержания оксида азота в выдыхаемом воздухе (FeNO, ppb) у 113 человек, среди которых было 26 здоровых (контрольная группа) и 87 больных [64 бронхиальной астмой (БА) и 23 - хронической обструктивной болезнью легких (ХОБЛ)]. среди больных БА у 10 человек было легкое течение БА (БАЛт), у 50 - БА средней тяжести (БАСТ) и у 4 - тяжелое течение БА (БАтт). У 20 больных БА сочеталась с ХОБЛ. Установлено, что у больных БА FeNO зависит от многих факторов: от тяжести течения заболевания (у больных БАТТ и БАСТ FeNO достоверно выше, чем у больных БАЛт), от фазы БА (в фазу обострения FeNO достоверно выше, чем в фазу ремиссии), от курабельности больных (у труднокурабельных больных БА FeNO достоверно выше, чем у остальных больных). У больных ХОБЛ отмечен низкий уровень FeNO (достоверно более низкий, чем у больных БА). Даже при высокой клеточности мокроты, что свидетельствует о выраженном воспалении органов дыхания, у больных ХОБЛ определяется низкий уровень FeNO.

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