<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">523</article-id><article-id pub-id-type="doi">10.36691/RJA523</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Allergen-specific skin prick tests in allergist practice</article-title><trans-title-group xml:lang="ru"><trans-title>Аллерген-специфические кожные пробы уколом (prick-tests) в работе врача-аллерголога</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gushchin</surname><given-names>I S</given-names></name><name xml:lang="ru"><surname>Гущин</surname><given-names>Игорь Сергеевич</given-names></name></name-alternatives><email>igushchin@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Danilycheva</surname><given-names>I V</given-names></name><name xml:lang="ru"><surname>Данилычева</surname><given-names>И В</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Institute of Immunology</institution></aff><aff><institution xml:lang="ru">ФГБУ «ГНЦ Институт иммунологии» ФМБА России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2013-08-15" publication-format="electronic"><day>15</day><month>08</month><year>2013</year></pub-date><volume>10</volume><issue>4</issue><issue-title xml:lang="en">NO4 (2013)</issue-title><issue-title xml:lang="ru">№4 (2013)</issue-title><fpage>44</fpage><lpage>53</lpage><history><date date-type="received" iso-8601-date="2020-03-10"><day>10</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2013, Pharmarus Print Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2013, Фармарус Принт Медиа</copyright-statement><copyright-year>2013</copyright-year><copyright-holder xml:lang="en">Pharmarus Print Media</copyright-holder><copyright-holder xml:lang="ru">Фармарус Принт Медиа</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2015-12-15"/></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/523">https://rusalljournal.ru/raj/article/view/523</self-uri><abstract xml:lang="en"><p>Identification of patient’s allergen-specific hypersensitivity and its clinical value is a basis of the right choice allergen-specific treatment. The problem is solved by an allergist with the use of different diagnostic methods. The most important stage of diagnostics is an allergen-specific skin testing more widely used as a skin prick testing (SPT). The paper concerns SPT technique, indications and contraindications for the testing, interpretations of SPT results, performance at certain groups of patients, the most probable mistakes in carrying out SPT, the reasons of false positive and false negative results, a comparative assessment of SPT and other methods of allergen-specific diagnostics, requirements to allergenic extracts.</p></abstract><trans-abstract xml:lang="ru"><p>Выявление аллерген-специфической гиперчувствительности пациента и ее клинического значения является основой правильного выбора аллерген-специфического лечения. Эта задача решается врачом-аллергологом с помощью использования разных диагностических приемов. Важнейшим этапом диагностики остается аллерген-специфическое кожное тестирование с использованием кожных проб уколом (КПУ). В статье рассматриваются особенности методики проведения КПУ, интерпретации результатов, особенностей выполнения КПУ у определенных групп пациентов, наиболее вероятные ошибки в проведении КПУ, причины ложноположительных и ложноотрицательных результатов, сравнительная оценка КПУ и других методов аллерген-специфической диагностики, требования к аллергенным экстрактам.</p></trans-abstract><kwd-group xml:lang="en"><kwd>allergen-specific diagnostics</kwd><kwd>IgE-mediated hypersensitivity</kwd><kwd>skin prick tests</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>аллерген-специфическая диагностика</kwd><kwd>IgE-опосредованная гиперчувствительность</kwd><kwd>кожные пробы уколом</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Гущин И.С., Курбачева О.М. Аллергия и аллергенспецифическая иммунотерапия. М., «Фармарус Принт Медиа». 2010, 228 с.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Heinzerling L., Mari A., Bergmann K. et al. The skin prick test -European standards. Clinical and Translational Allergy. 2013, v. 3, р. 3.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Heinzerling L., Burbach G.J., Edanharter G. et al. GA(2)LEN skin test study I: GA(2)LEN harmonization of skin prick testing: novel sensitization pattern for inhalant allergens in Europe. Allergy. 2009, v. 64, p. 1498-1506.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Bousquet J., Heinzerling L., Bachert C. et al. Practical guide to skin prick tests in allergy to aeroallergens. Allergy. 2012, v. 67, p. 18-24.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Van Kampen V., de Blay F., Folletti I. et al. EAACI position paper: skin prick testing in the diagnosis of occupational type I allergies. Allergy. 2013, v. 68, p. 580-584.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Ebruster H. The prick test, a recent cutaneous test for the diagnosis of allergic disorders. Wien Klin. Wochenschr. 1959, v. 71, p. 551-554.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Heinzerling L., Friew A.J., Bindslev-Jensen C. et al. Standard skin prick testing and sensitization on inhalant allergens across Europe - a survey from GALEN network. Allergy. 2005, v. 60, р. 1287-1300.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Masse M.S., Granger Vallee A., Chiriac A. et al. Comparison of five techniques of skin prick tests used routinely in Europe. Allergy. 2011, v. 66, p. 1415-1419.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Burbach G.J., Heinzerling L.M., Edenharter G. et al. GA(2)LEN skin test study ILclinical relevance of inhalant allergen sensitizations in Europe. Allergy. 2009, v. 64, p. 1507-1515.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Hagy G.W., Settipane G.A. Prognosis of positive allergy skin tests in an asymptomatic population. A three year follow-up of college students. J. Allergy Clin. Immunol. 1971, v. 48, p. 200-211.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Horak F. The allergen quick test: a simple allergy test to prove existing sensitization. Arch. Otorhinolaryngol. 1985, v. 242, p. 233-238.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Reid M.J., Lockey R.F., Turkeltaub P.C., Platts-Mills T.A. Survey of fatalities from skin testing and immunotherapy 1985-1989. J. Allergy Clin. Immunol. 1993, v. 92, No. 1, pt. 1, p. 6-15.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Lockey R.F., Benedict L.M., Turkeltaub P.C., Bukantz S.C. Fatalities from immunotherapy (IT) and skin testing (ST). J. Allergy Clin. Immunol. 1987, v. 79, p. 660-677.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Novembre E., Bernardini R., Bertini G. et al. Skin-prick-test-induced anaphylaxis. Allergy. 1995, v. 50, p. 511-513.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>RueffF., Przibilla B., Bilo M.B. et al. Predictors of severe systemic anaphylactic reactions in patients with Hymenoptera venom allergy: importance of baseline serum tryptase - a study of the European Academy of Allergology and Clinical Immunology Interest Group on Insect Venom Hypersensitivity. J. Allergy Clin. Immunol. 2009, v. 124, p. 1047-1054.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Bernstein I.L., Storms W.W. Practice parameters for allergy diagnostic testing. Ann. Allergy Asthmа Immunol. 1995, v. 75, No 6, pt. 2, p. 543-625.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Vocks E., Stander K., Rakoski J., Ring J. Suppression of immediate-type hypersensitivity elicitation in the skin prick test by ultraviolet B irradiation. Photodermatol. Photoimmunol. Photomed. 1999, v. 15, p. 236-240.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Медуницына Е.Н. Аллергологические методы обследования. В кн.: Аллергология и иммунология: национальное руководство. Под ред. Р.М. Хаитова, Н.И. Ильиной. М., «ГЭОТАР-Медиа». 2009, с. 20-24.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Nelson, H.S., Knoetzer J., Bucher B. Effect of distance between sites and region of the body on results of skin prick tests. J. Allergy Clin. Immunol. 1996, v. 97, p. 596-601.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Carr W.W., Martin B., Howard R.S. et al. Comparison of test devices for skin prick testing. J. Allergy Clin. Immunol. 2005, v. 116, p. 341-346.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Nelson H.S., Kolehmainen C., Lahr J. et al. A comparison of multiheaded devices for allergy skin testing. J. Allergy Clin. Immunol. 2004, v. 113, p. 1218-1219.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Demoly P., Bousquet J., Manderscheid J.C. et al. Precision of skin prick and puncture tests with nine methods. J. Allergy Clin. Immunol. 1991, v. 88, p. 758-762.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Werther R.L., Choo S., Lee K. et al. Variability in skin prick test results performed by multiple operators depends on the device used. WAO Journal. 2012, v. 5, p. 200-204.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Henzgen M., Ballmer-Wber B.K., Erdmann S. et al. Skin testing with food allergens. J. Dtsch. Dermatol. Ges. 2008, v. 6, p. 983-988.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Konstantinou G.N., Bousquet J., Zuberbier T., Papadopoulos N.G. The longest wheal diameter is the optimal measurement for the evaluation of skin prick test. Int. Arch. Allergy Immunol. 2010, v. 151, p. 343-345.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Гущин И.С., Фридлянд Д.Г., Порошина Ю.А. Индивидуализация выбора Н1-антагонистов для лечения аллергического ринита. Аллергия, астма и клин. иммунол. 2001, № 8, с. 8-17.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Demoly P., Bousquet J., Romano A. In vivo methods for the study of allergy. In: Middleton’s Allergy - Principles and Practice. 6th edition. Edited by N.J. Adkinson, J. Yunginger, Busse W., D. Bochner, S. Holgate, F. Simons. «Mosby», Philadelphia. 2003, p. 430-439.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Crobach M.J., Hermans J., Kaptein A.A. et al. The diagnosis of allergic rhinitis: how to combine the medical history with results of radicallergosorbent tests and skin prick tests. Scand. J. Prim. Health Care. 1998, v. 16, p. 30-36.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Verstege A., Mehl A., Rolinck-Werninghaus C. et al. The predictive value of the skin prick test wheal size for the outcome of oral food challenges. Clin. Exp. Allergy. 2005, v. 35, p. 1220-1226.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Gruchalla R. Understanding drug allergies. J. Allergy Clin. Immunol. 2000, v. 105, Na 6, pt. 2, p. S637-S644.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Salkind A.R., Cuddy P.G., Foxworth J.W. The rational clinical examination. Is this patient allergic to penicillin? An evidence-based analysis ofthe likelihood of penicillin allergy. JAMA. 2001, v. 285, p. 2498-2505.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Rhodius R., Wickens K., Cheng S., Crane J. A comparison of two skin test methodologies and allergens from two different manufacturers. Ann. Allergy Asthma Immunol. 2002, v. 88, p. 374-379.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Nielsen N.H., Dirksen A., Mosbech H. et al. Skin prick testing with standardized extracts from 3 diffrerent different manufacturers. A comparative randomizes study. Allergol. Immunopathol. 1992, v. 20, p. 246-248.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Eichler I., Gotz M., Jarisch R. et al. Reproducibility of skin prick testing with allergen extracts from different manufacturers. Allergy. 1988, v. 43, p. 458-463.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Focke M., Marth K., Flicker S., Valenta R. Heterogenety of commertial timothy grass pollen extracts. Clin. Exp. Allergy. 2008, v. 38, p. 1400-1408.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Van R.R., Chapman M.D., Ferreira F. et al. The CREATE project: development of certified reference materials for allergenic products and validation of methods for their quantification. Allergy. 2008, v. 63, p. 310-326.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Van Kampen V., de Blay F., Folletti I. et al. Evaluation of commercial skin prick test solutions for selected occupational allergens. Allergy. 2013, v. 68, p. 651-658.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Wood R.A., Phipatanakul W., Hamilton R.G., Eggleston P.A. A comparison of skin prick tests, intradermal skin tests, and RASTs in the diagnosis of cat allergy. J. Allergy Clin. Immunol. 1999, v. 103, No 5, pt. 1, p. 773-779.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Riezzo I., Bello S., Neri M. et al. Ceftriaxone intradermal test-related fatal anaphylactic shock: a medico-legal nightmare. Allergy. 2010, v. 65, p. 130-131.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Гущин И.С., Читаева В.Г. Аллергия к насекомым. Клиника, диагностика и лечение. М., «Фармарус Принт». 2003, 328 с.</mixed-citation></ref></ref-list></back></article>
