Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press48010.36691/RJA480ArticlesСтатьиReview ArticleREVIEW OF THE ROLE OF PERIOSTIN AS A NOVEL BIOMARKER OF BRONCHIAL ASTHMAОбзор роли периостина - нового биологического маркера при бронхиальной астмеMasalskiyS SМасальскийС Сmasalsky@live.comKalmikovaA SКалмыковаА СUkhanovaO PУхановаО ПKlimovL YКлимовЛ ЯRazgulaevaA VРазгуляеваА ВStavropol State Medical UniversityСтавропольский государственный медицинский университет15122014116NO6 (2014)№6 (2014)5810032020Copyright ©; 2014, Pharmarus Print MediaCopyright ©; 2014, Фармарус Принт Медиа2014Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/480

The survey shows the role of periostin in the asthma research. This is extracellular protein involved in the pathogenesis of chronic inflammation in asthma in children and adults. The role of periostin in the pathogenesis of atopic and nonatopic diseases was analyzed in this review. The appearance of the biomarker, responsible for airways remodeling, can give a clear understanding of the clinical stage of the process and the ability to achieve asthma control. Correlation between periostin, peripheral blood eosinophilia and fractional exhaled nitric oxide can be considered as an additional criterion for control of the disease.

В обзоре показана роль периостина - экстрацеллюлярного белка, который участвует в патогенезе хронического воспаления при бронхиальной астме (БА) у детей и взрослых. Проанализирована роль периостина в патогенезе атопических и неатопических заболеваний. Появление маркера, ответственного за ремоделирование стенки бронха, дает четкое понимание стадии клинического процесса и возможность адекватно назначать дозы противовоспалительной терапии. Корреляция между периостином, эозинофилами периферической крови, азотом выдыхаемого воздуха может служить дополнительным критерием контроля над заболеванием.

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