Russian Journal of Allergy

Российский Аллергологический Журнал

1810-88302686-682X

Publishing House ABV Press

471

10.36691/RJA471

Articles

Статьи

Research Article

Sputum characteristics and evaluation of airways inflammation peculiarities in patients with bronchial asthma and chronic obstructive pulmonary disease

Характеристика мокроты для оценки наличия и характера воспаления бронхолегочного аппарата у больных бронхиальной астмой и хронической обструктивной болезнью легких

Fedoseev

G B

Федосеев

Г Б

fedoseevsp@mail.ru

Trofimov

V I

Трофимов

В И

Negrutsa

K V

Негруца

К В

Timchik

V G

Тимчик

В Г

Zueva

E E

Зуева

Е Е

Gorovneva

E V

Горовнёва

Е В

Rogachevskaya

N N

Рогачевская

Н Н

Razumovskaya

T S

Разумовская

Т С

Alexandrin

V A

Александрин

В А

Golubeva

V I

Голубева

В И

Birula

I V

Бируля

И В

Filippova

N A

Филиппова

Н А

Kryakunov

K N

Крякунов

К Н

First SaintPetersburg State Medical University named after I.P. PavlovПервый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова

15022015

121

NO1 (2015)

№1 (2015)

152610032020

2015

Pharmarus Print Media

Фармарус Принт Медиа

https://rusalljournal.ru/raj/article/view/471

Background. The aim of the study was to investigate cellular phenotypes of the spontaneous sputum, estimate possibilities of cytological sputum analysis in evaluation of airways inflammation peculiarities in comparison with the expired nitric oxide level and respiratory function tests. Materials and methods. functional properties of neutrophils were evaluated by respiratory burst intensity. 72 patients were included, 23 - with moderate bronchial asthma course and chronic bronchitis, 18 - with moderate bronchial asthma and COPD, 31 patient had COPD only. All patients were examined in the exacerbation period, all of them had productive cough. Results. Cytological phenotypes were stated as well as the links between different sputum cells presence and between cytological peculiarities, inflammation and functional state of the respiratory system. Functional defects of neutrophils were found in COPD patients.

Исследование поведено с целью установления клеточных фенотипов спонтанной мокроты, оценки особенностей воспаления органов дыхания по данным цитологического исследования мокроты, определения соотношения между клетками мокроты и показателями, характеризующими воспаление и функциональное состояние органов дыхания с учетом выраженности воспаления по данным уровня оксида азота в выдыхаемом воздухе. Функциональное состояние нейтрофилов мокроты оценивалось по выраженности кислородного взрыва и фагоцитоза. Исследованы 72 больных, из них 23 больных бронхиальной астмой средней тяжести течения в сочетании с хроническим бронхитом (БАСТ+ХБ), 18 - бронхиальной астмой средней тяжести течения в сочетании с хронической обструктивной болезнью легких (БАСТ+ХОБЛ) и 31 больной ХОБЛ. Все больные обследовались в фазу обострения болезни, у всех имелся кашель с мокротой. Были установлены цитологические фенотипы, взаимосвязи между клетками мокроты, связь особенностей цитограмм с показателями, характеризующими воспаление и функциональное состояние органов дыхания. выявлена функциональная неполноценность нейтрофилов мокроты у больных ХОБЛ.

bronchial asthmachronic obstructive pulmonary diseasechronic bronchitiscellular phenotypes of spontaneous sputuminflammation

бронхиальная астмахроническая обструктивная болезнь легкиххронический бронхитмокротаклеточные фенотипы мокротывоспаление

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