Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press46210.36691/RJA462ArticlesСтатьиResearch ArticleImmunobiological medicines in treatment of bronchial asthma: experience and prospects of applicationИммунобиологические препараты в лечении бронхиальной астмы: опыт и перспективы применения (Совет экспертов)IlyinaN IИльинаН ИKurbachevaO MКурбачеваО МSizyakinaL PСизякинаЛ ПUkhanovaO PУхановаО ПShogenovaM SШогеноваМ СBrisinV YuБрисинВ ЮInstitute of ImmunologyФГБУ «ГНЦ Институт иммунологии» ФМБА РоссииRostov State Medical university of the Russian Ministry of HealthРостовский государственный медицинский университет Минздрава РоссииInstitute of Postdegree Education of the Stavropol State Medical UniversityИнститут последипломного образования ставропольского государственного медицинского университетаCenter of Allergology of Public Health Ministry of KBRГУЗ «Центр аллергологии» М3 КБРChildren's Regional Clinical Hospital of Krasnodar KraiДетская краевая клиническая больница Краснодарского края15102015125NO5 (2015)№5 (2015)909310032020Copyright ©; 2015, Pharmarus Print MediaCopyright ©; 2015, Фармарус Принт Медиа2015Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/462[Bateman E.D., Boushey H.A., Bousquet J. et al. Can guideline-defined asthma control be achieved? The Gaining Op timal Asthma Control study. Am. J. Respir. Crit. Care Med. 2004, v. 170, р. 836-844.][Partridge M.R., van der Molen T., Myrseth S.E., Busse W.W. Attitudes and actions ofasthma patients on regular maintenance therapy: the INSPIRE study. BMC Pulm. Med. 2006, v. 6, р. 13.][Novelli F., Latorre M., Vergura L. et al. Asthma control in severe asthmatics under treatment with omalizumab: A cross-sectional observational study in Italy. Pulmonary Pharmacology & Therapeutics. 2015, v. 31, р. 123-129.][Roth M., Zhong J., Zumkeller S. et al. The Role of IgE-Receptors in IgE-Dependent Airway Smooth Muscle Cell Remodelling. PLoS One. 2013, v. 8, e56015.][Burrows B., Martinez F.D., Halonen M. et al. Association of asthma with serum IgE levels and skin-test reactivity to allergens. N. Engl. J. Med. 1989, v. 320, р. 271-277.][Zureik M., Neukirch C., Leynaert B. et al. Sensitization to airborne moulds and severity of asthma: cross sectional study from European Community respiratory health survey. BMJ. 2002, v. 325, р. 411.][Mouthuy J., Detry B., Sohy C. et al. Presence in sputum of functional dust mite-specific IgE antibodies in intrinsic asthma. Am. J. Respir. Crit. Care Med. 2011, v. 184, р. 206-214.][Busse W.W., Morgan W.J., Gergen P.J. et al. Randomized trial of omalizumab (anti-IgE) for asthma in inner-city children. N. Engl. J. Med. 2011, v. 364, р. 1005-1015.][James L., Wenzel S. Clinical relevance of airway remodeling in airway diseases. Eur. Respir. J. 2007, v. 30, р. 134-155.][Wenzel S.E., Schwartz L.B., Langmack E.L. et al. Evidence that severe asthma can be divided pathologically into two inflammatory subtypes with distinct physiologic and clinical characteristics. Am. J. Respir. Crit. Care Med. 1999, v. 160, р. 1001-1008.][Rabe K.F., Calhoun W.J., Smith N., Jimenez P. Can anti-IgE therapy prevent airway remodeling in allergic asthma? Allergy. 2011, v. 66, р. 1142-1151.][Hoshino M., Ohtawa J. Effects of adding omalizumab, an anti-immunoglobulin E antibody, on airway wall thickening in asthma. Respiration. 2012, v. 83, р. 520-528.][Roth M., Zhong J., Zumkeller S. et al. The Role of IgE-Receptors in IgE-Dependent Airway Smooth Muscle Cell Remodelling. PLoS One. 2013, v. 8, e56015.][Nopp A., Johansson S.G.O., Adedoyin J. After 6 years with Xolair; a 3-year withdrawal follow-up. Allergy. 2010, v. 65, р. 56-60.][Wang C., Zhang L. Specific immunotherapy for allergic rhinitis in children. Curr. Opin. Otolaryngol. Head. Neck. Surg. 2014, v. 22, р. 487-494.]