<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE root>
<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">405</article-id><article-id pub-id-type="doi">10.36691/RJA405</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Intranasal steroids in treatment of allergic rhinitis</article-title><trans-title-group xml:lang="ru"><trans-title>Интраназальные кортикостероиды в лечении аллергического ринита</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kurbacheva</surname><given-names>O M</given-names></name><name xml:lang="ru"><surname>Курбачева</surname><given-names>О М</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Shwets</surname><given-names>S M</given-names></name><name xml:lang="ru"><surname>Швец</surname><given-names>С М</given-names></name></name-alternatives><email>smshvets@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Institute of Immunology</institution></aff><aff><institution xml:lang="ru">ФГБУ «ГНЦ Институт иммунологии» ФМБА Госсии</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2015-12-15" publication-format="electronic"><day>15</day><month>12</month><year>2015</year></pub-date><volume>12</volume><issue>6</issue><issue-title xml:lang="en">NO6 (2015)</issue-title><issue-title xml:lang="ru">№6 (2015)</issue-title><fpage>72</fpage><lpage>79</lpage><history><date date-type="received" iso-8601-date="2020-03-10"><day>10</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2015, Pharmarus Print Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2015, Фармарус Принт Медиа</copyright-statement><copyright-year>2015</copyright-year><copyright-holder xml:lang="en">Pharmarus Print Media</copyright-holder><copyright-holder xml:lang="ru">Фармарус Принт Медиа</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2017-12-15"/></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/405">https://rusalljournal.ru/raj/article/view/405</self-uri><abstract xml:lang="en"><p>Allergic rhinitis (AR) is one of the most common diseases affecting adults and children. AR is often a part of a systemic inflammatory process associated with other inflammatory conditions, including allergic conjunctivitis (Ac), rhinosinusitis and asthma. Undertreated AR impairs quality of life, exacerbates asthma and is a major factor in asthma development. There is a strong recommendation that clinicians recommend intranasal steroids (INS) for patients with a clinical diagnosis of AR whose symptoms affect their quality of life. All modern INS are minimally bioavailable and similar with regard to efficacy and safety at the recommended starting dose. however, differences in patient preference and safety of use during pregnancy may contribute to primary care physicians’ selection of an INS therapy for their patients.</p></abstract><trans-abstract xml:lang="ru"><p>Аллергический ринит (АР) - широко распространенное заболевание, значительно влияющее на качество жизни. АР является проявлением системного аллергического процесса и часто сочетается с другими аллергическими заболеваниями. Недиагностированный и нелеченный аллергический ринит значительно ухудшает течение бронхиальной астмы. Интраназальные кортикостероиды (ИНКС) рекомендованы в качестве первой линии терапии среднетяжелого и тяжелого аллергического ринита. Современные ИНКС безопасны и хорошо переносятся. Учет субъективных ощущений пациентов при применении ИНКС, удобство и безопасность использования, в том числе во время беременности, улучшают приверженность пациентов рекомендуемой терапии и позволяют врачам выбрать для своих пациентов наиболее подходящий ИНКС.</p></trans-abstract><kwd-group xml:lang="en"><kwd>allergic rhinitis</kwd><kwd>intranasal steroids</kwd><kwd>efficacy</kwd><kwd>safety</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>аллергический ринит</kwd><kwd>интраназальные кортикостероиды</kwd><kwd>эффективность</kwd><kwd>безопасность</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Bousquet J., Khaltaev N., Cruz A. et al. ARIA Update. Allergy. 2008, v. 63, 160 р.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Szeinbach S.L., Seoane-Vazquez E.C., Beyer A., Williams P.B. The impact of allergic rhinitis on work productivity. Prim. Care Respir. 2007, v. 16, p. 98-105.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Meltzer E.O. Quality of life in adults and children with allergic rhinitis. J. Allergy Clin. Immunol. 2001, v. 108, p. 45-53.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Beggs PJ. Impacts of climate change on aeroallergens: past and future. Clin. Exp. Allergy. 2004, v. 34, p. 1507-1513.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Rogers C.A., Wayne P.M., Macklin E.A et al. Interaction of the onset of spring and elevated atmospheric CO2 on ragweed (Ambrosia artemisiifolia L.) pollen production. Environ Health Perspect. 2006, v. 114, p. 865-869.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Burbach G.J., Heinzerling L.M., Edenharter G. et al. GA2LEN skin test study II: clinical relevance of inhalant allergen sensitizations in Europe. Allergy. 2009, v. 64, p. 1507-1515.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Bertelsen R.J., Carlsen K.C., Carlsen K.H. Rhinitis in children: co-morbidities and phenotypes. Pediatr. Allergy Immunol. 2010, v. 21, p. 612.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Chawes B.L., Bonnelykke K., Kreiner-Moller E. et al. Children with allergic and nonallergic rhinitis have a similar risk of asthma. Allergy Clin. Immunol. 2010, v. 126, p. 567-573.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Ponte E.V., Franco R., Nascimento H.F. et al. Lack of control of severe asthma is associated with co-existence of moderate -to-severe rhinitis. Allergy. 2008, v. 63, p. 564-569.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Masuda S., Fujisawa T., Katsumata H. et al. High prevalence and young onset of allergic rhinitis in children with bronchial asthma. Pediatr Allergy Immunol. 2008, v. 19, p. 517-522.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>De Groot E.P., Nijkamp A., Duiverman E.J. et al. Allergic rhinitis is associated with poor asthma control in children with asthma. Thorax. 2012, v. 67, p. 582-587.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Lasmar L.M., Camargos P. A., Ordones A. et al. Prevalence of allergic rhinitis and its impact on the use of emergency care services in a group of children and adolescents with moderate to severe persistent asthma. Pediatr. 2007, v. 83, p. 555-561.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Canonica G.W., Compalati E. Minimal persistent inflammation in allergic rhinitis: implications for current treatment strategies. Clin. Exp. Immunol. 2009, v. 158, p. 260-271.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Cirillo I., Marseglia G., Klersy C. et al. Allergic patients have more numerous and prolonged respiratory infections than non-allergic subjects. Allergy. 2007, v. 62, p. 1087-1090.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Гущин И.С. Аллергическое воспаление и его фармакологический контроль. М., «Фармарус Принт Медиа». 1998, 248 с.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Гущин И.С., Курбачева О.М. Аллергия и аллергенспеци-фическая иммунотерапия. М., «Фармарус Принт Медиа». 2010, 227 с.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Mori L., Kleimberg J., Mancini C. et al. Bronchial epithelial cells of atopic pacients with asthma lack the ability to inactivate allergens. Biochem. Biophys. Res. Commun. 1995, v 217, p. 817-822.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Rapiejko P., Stankiewicz W., Szczygielski K. et.al. Threshold pollen count necessary to evoke allergic symtoms. Otolaringol. Pol. 2007, v. 61, p. 591-594.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Weiner J.M., Abramson M.J., Puy R.M. Intranasal corticosteroids versus oral H1-receptor antagonists in allergic rhinitis: systematic review of randomised controlled trials. BMJ. 1998, v. 317, p. 1624-1629.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Yanez A., Rodrigo G.J. Intranasal corticosteroids versus topical H1-receptor antagonists for the treatment of allergic rhinitis: a systematic review with meta-analysis. Ann. Allergy Asthma Immunol. 2002, v. 89, p. 479-484.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Weinstein S.F. Combination therapy in the treatment of allergic rhinitis. Allergy Asthma Proc. 2002, v. 23, p. 1-3.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>российский Аллергологический ^Журнал № 6-2015 Интраназальные кортикостероиды в лечении аллергического ринита</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Skoner D., Rachelefsky G., Meltzer E. et al. Detection of growth suppression in children during treatment with intranasal belcomethasone dipropionate. Pediatrics. 2000, v. 105, p. 23.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Allen D.B., Meltzer E.O., Lemanske R.F. et al. No growth suppression in children treated with the maximum recommended dose of fluticasone propionate aqueous nasal spray for one year. Allergy Asthma Proc. 2002, v. 23, p. 407-413.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Schenkel E.J., Skoner D.P., Bronsky E.A. et al. Absence of growth retardation in children with perennial allergic rhinitis after one year of treatment with mometasone furoate aqueous nasal spray. Pediatrics. 2000, v. 105, p. 22.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Lee L., Sterling R., Maspero J. et al. Growth velocity reduced with once-daily Fluticasone furoate nasal spray in prepubes-cent children with perennial allergic rhinitis. JACI Pract. 2014, v. 2, p. 421-427.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Kim K.T., Rabinovitch N., Uryniak T. et al. Effect of budesonide aqueous nasal spray on hypothalamic-pituitary-adrenal axis function in children with allergic rhinitis. Ann. Allergy Asthma Immunol. 2004, v. 93, p. 61-67.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Muller C., Ahlstrom H., Henricson K.A. et al. Safety of nasal budesonide in the long-term treatment of children with perennial rhinitis. Clinical &amp; Experimental Allergy. 2003, v. 6, p. 816-822.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Glenis K. Scadding. Optimal Management of Allergic Rhinitis. Arch. Dis. Child. 2015, v. 100, p. 576-582.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Marple B.F., Fornadley J.A., Patel A.A. et al. Keys to successful management of patients with allergic rhinitis: focus on patient confidence, compliance, and satisfaction. Otolaryngol. Head Neck Surg. 2007, v. 136, p. 107-124.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Keith P.K., Desrosiers M., Laister T. et al. The burden of allergic rhinitis in Canada: perspectives of physician and patients. Allergy Asthma Clin. Immunol. 2012, v. 1, p. 8.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Baena-Cagnani C.E. Safety and tolerability of treatments for allergic rhinitis in children. Drug. Saf. 2004, v. 27, p. 883-898.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Lindqvist N., Balle V.H., Karma P. et al. Long-term safety and efficacy of budesonide nasal aerosol in perennial rhinitis. A 12-month multicentre study. Allergy. 1986, v. 41, p. 179-186.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Pipkorn U., Pukander J., Suonpaa J. et al. Long-term safety of budesonide nasal aerosol: a 5.5-year follow-up study. Clin. Allergy. 1988, v. 18, p. 253-259.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Norjavaara E., de Verdier M.G. Normal pregnancy outcomes in a population-based study including 2,968 pregnant women exposed to budesonide. J. Allergy Clin. Immunol. 2003, v. 111, p. 736-742.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Kallen B., Rydhstroem H., Aberg A. Congenital malformations after the use of inhaled budesonide in early pregnancy. Obstet. Gynecol. 1999, v. 93, p. 392-395.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>U.S. Food and Drug Administration. U.S. FDA labeling and prescription drug advertising: content and format for labeling for human prescription drugs. Fed. Regist. 1979, v. 44, p. 37434-37467.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Yawn B. Comparison of once-daily intranasal corticosteroids for the treatment of allergic rhinitis: are they all the same? Med. Gen. Med. 2006, v. 25, p. 23.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Курбачева О.М., Польнер С.А., Смирнов Д.С. Аллергический ринит. Вечная проблема и ее современное решение. Медицинский совет. Оториноларингология. 2015, № 5, c. 84-91.</mixed-citation></ref></ref-list></back></article>
