Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press38410.36691/RJA384ArticlesСтатьиResearch ArticleInfectious and noninfectious sensibilization of patients with bronchial asthma and chronic obstructive pulmonary diseaseИнфекционная и неинфекционная сенсибилизация больных бронхиальной астмой и хронической обструктивной болезнью легкихFedoseevG BФедосеевГ Бfedoseevsp@mail.ruTrofimovV IТрофимовВ ИTimchikV GТимчикВ ГNegrutsaK VНегруцаК ВGolubevaV IГолубеваВ ИGorovnevaE VГоровневаЕ ВRazumovskayaT SРазумовскаяТ СBirulaI VБируляИ ВAlexandrinV AАлександринВ АKryakunovK NКрякуновК НFirst Saint-Petersburg State I.P. Pavlov Medical UniversityПервый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова15122015126NO6 (2015)№6 (2015)395310032020Copyright ©; 2015, Pharmarus Print MediaCopyright ©; 2015, Фармарус Принт Медиа2015Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/384

The study included 169 patients, particulary 33 healthy people, 69 patients with asthma, 24 patients with asthma combined with chronic obstructive pulmonary disease, 35 patients with chronic obstructive pulmonary disease and 8 patients with community-acquired pneumonia. IgE was determined to mite allergens, house dust, combined pollen meadow grasses, trees and weeds. IgE and IgG were determined to allergens of Strept. pneumonia, Haemofil. influenzae, Neisseria perflava, Staph. aureus. Presence, multiplicity, severity and combination of sensibilization were detected by the presence of specific IgE to infectious and atopic allergens. We revealed sensibilization of all studied groups, including healthy people and patients with chronic obstructive pulmonary disease and community-acquired pneumonia without clinical signs of allergies. There is a statistically significant direct correlation between IgE and IgG reaction to Strept. рneumonia and Haemofil. influenzae of healthy people and patients. There is no correlation between the IgE and IgG reaction of healthy people and patients to Neisseria perflava and Staph. aureus.

Обследованы 169 человек, из них 33 практически здоровых, 69 больных бронхиальной астмой, 24 больных бронхиальной астмой в сочетании с хронической обструктивной болезнью легких, 35 больных хронической обструктивной болезнью легких и 8 больных внебольничной пневмонией. IgE определялся к аллергенам клеща домашней пыли, бытовой пыли, сборным аллергенам пыльцы луговых трав, деревьев и сорных трав. IgE и IgG определялись к аллергенам Strept. pneumon, Haemofil. influenzae, Neisseria perflava, Staph. aureus. Определялись наличие, распространенность, выраженность и сочетанность сенсибилизации по наличию IgE к инфекционным и атопическим аллергенам. выявлена сенсибилизация среди участников всех групп исследованных, включая здоровых и больных хронической обструктивной болезнью легких и внебольничной пневмонией без клинических признаков аллергии. Установлена статистически достоверная прямая корреляция между IgG и IgE к Strept. pneumoniae и Haemofilus influenza у здоровых и больных. Реакция здоровых и больных на Neisseria perflava и Staph. aureus, по данным определения IgE и IgG, не сопровождается достоверной корреляцией.

sensibilizationallergybronchial asthma mild coursebronchial asthma moderate coursebronchial asthma moderate course combined with chronic obstructive pulmonary diseasechronic obstructive pulmonary diseasecommunity-acquired pneumoniaimmunoglobulinallergenantigenсенсибилизацияаллергиябронхиальная астма легкое течениебронхиальная астма течение средней тяжестибронхиальная астма средней тяжести в сочетании с хронической обструктивной болезнью легкиххроническая обструктивная болезнь легкихвнебольничная пневмонияиммуноглобулиналлергенантигенBunyavvanich S. Systems biology of asthma and allergic diseases: A multiscale approach. J. Allergy Clin. Immunol. 2015, v. 135, p. 31-42.Hilty M., Burke C., Pedro H. et al. Disordered microbial communities in asthmatic airways. Plos ONE. 2010, 05. Doi 10, 137/journal. Pone. 0008578.Huang YJ., Nelson C.E., Brodie E.L. et al. Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma. Allergy Clin. 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