Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press35410.36691/RJA354ArticlesСтатьиResearch ArticleRegarding to the issue of the role of cytokines in the pathogenesis of asthma and the possibilities of anticytokine therapyК вопросу о роли цитокинов в патогенезе бронхиальной астмы и возможностях антицитокиновой терапииFedoseevG BФедосеевГ Б

Кафедра госпитальной терапии им. акад. М.В. Черноруцкого

fedoseevsp@mail.ruTrofimovV IТрофимовВ И

Кафедра госпитальной терапии им. акад. М.В. Черноруцкого

NegrutsaK VНегруцаК В

Кафедра госпитальной терапии им. акад. М.В. Черноруцкого

TimchikV GТимчикВ Г

Кафедра госпитальной терапии им. акад. М.В. Черноруцкого

GolubevaV IГолубеваВ И

Кафедра госпитальной терапии им. акад. М.В. Черноруцкого

AleksandrinV AАлександринВ А

Кафедра госпитальной терапии им. акад. М.В. Черноруцкого

RazumovskayaT SРазумовскаяТ С

Кафедра госпитальной терапии им. акад. М.В. Черноруцкого

KryakunovK NКрякуновК Н

Кафедра госпитальной терапии им. акад. М.В. Черноруцкого

Academician I.P. Pavlov First St. Petersburg State Medical UniversityПервый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова15122016136NO6 (2016)№6 (2016)233610032020Copyright ©; 2016, Pharmarus Print MediaCopyright ©; 2016, Фармарус Принт Медиа2016Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/354

The study involved 210 people, of which 32 had mild bronchial asthma, 39 had moderate bronchial asthma, 39 had moderate bronchial asthma combined with chronic obstructive pulmonary disease, 38 had chronic obstructive pulmonary disease, 17 patients suffered from community-acquired pneumonia, 25 patients with essential hypertension and ischemic heart disease (comparison group) and 20 healthy patients. We assessed sIgE to mite allergens, dust allergens, and the mixed grass, trees, weeds and flower pollen allergens , Str. pneumon., Haemofil. influenzae, Neisseria perflava. The levels of interleukin-4, interleukin6, interleukinlO, interleukin-7, gamma-interferon, tumor necrosis factor were investigated. All patients were studied in the acute condition of the disease. We assessed the infectious potential and atopic potential in every patient. Results of the study allow to resume that cytokines levels, their combinations (cytokine profile) testing has not to be advisable for clinical diagnostics, assessement of the severity of the disease and treatment strategy including anti-cytokine therapy.

Были исследованы 210 человек, из них 32 - бронхиальная астма легкого течения (БАЛТ), 39 - бронхиальная астма среднетяжелого течения (БАСТ), 39 - БАСТ+ХОБЛ, 38 - ХОБЛ, 17 - внебольничная пневмония (ВП), 25 - гипертоническая болезнь (ГБ) и ИБС (сравнительная группа), 20 - здоровые. Проведено определение IgE к аллергенам клеща, бытовой пыли, сборным аллергенам пыльцы луговых трав, деревьев, сорных трав и цветов, Strept. pneumon., Haemophil. influenzae, Neisseria perflava. Исследовались цитокины: ИЛ-4, ИЛ-6, ИЛ-10, ИЛ-17, γ-интерферон (ГИН), ФНО. Все больные были обследованы в фазу обострения болезни. У каждого обследованного проведено определение инфекционного потенциала (ИНФП) и аллергического потенциала (АТП). Результаты изучения уровней цитокинов, сочетаний цитокинов (цитокинового профиля) позволяют утверждать, что они не могут быть использованы для целей клинической диагностики - нозологической диагностики, оценки тяжести течения заболевания и выбора индивидуальной терапии, включая антицитокиновые препараты.

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