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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">353</article-id><article-id pub-id-type="doi">10.36691/RJA353</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">To the question of prenatal predisposing factors to allergic diseases</article-title><trans-title-group xml:lang="ru"><trans-title>К вопросу о пренатальных факторах предрасположенности к аллергическим заболеваниям</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Lavrova</surname><given-names>O V</given-names></name><name xml:lang="ru"><surname>Лаврова</surname><given-names>Ольга Вольдемаровна</given-names></name></name-alternatives><email>loverova@bk.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Dymarskaya</surname><given-names>Y R</given-names></name><name xml:lang="ru"><surname>Дымарская</surname><given-names>Ю Р</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Petrova</surname><given-names>M A</given-names></name><name xml:lang="ru"><surname>Петрова</surname><given-names>М А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Fedoseev</surname><given-names>G B</given-names></name><name xml:lang="ru"><surname>Федосеев</surname><given-names>Г Б</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Pavlov's First Saint-Petersburg State Medical university</institution></aff><aff><institution xml:lang="ru">ГБОУ ВПО «Первый Санкт-Петербургский государственный медицинский университет им. академика И.П. Павлова» Министерства здравоохранения Российской Федерации</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2016-02-15" publication-format="electronic"><day>15</day><month>02</month><year>2016</year></pub-date><volume>13</volume><issue>1</issue><issue-title xml:lang="en">NO1 (2016)</issue-title><issue-title xml:lang="ru">№1 (2016)</issue-title><fpage>5</fpage><lpage>10</lpage><history><date date-type="received" iso-8601-date="2020-03-10"><day>10</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2016, Pharmarus Print Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2016, Фармарус Принт Медиа</copyright-statement><copyright-year>2016</copyright-year><copyright-holder xml:lang="en">Pharmarus Print Media</copyright-holder><copyright-holder xml:lang="ru">Фармарус Принт Медиа</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2018-12-15"/></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/353">https://rusalljournal.ru/raj/article/view/353</self-uri><abstract xml:lang="en"><p>Background. To study the peculiarities of pregnancy in asthma women and the health status of their children. Materials and methods. We examined the natural course and outcomes of pregnancy of 1010 women with asthma and monitored health status of their children up to 7 years old. Women were under the observation of pulmonologist and obstetrician throughout the period of gestation; they were treated if necessary and provided with recommendations for the primary prevention of allergic diseases in unborn child. Immediately after delivery children were under the supervision of a pediatrician, allergist. Results. Rising incidence of pregnancy complications in patients with asthma is directly related to the lack of control of the disease, especially in the first trimester of gestation. The lack of adequate treatment of asthma increases the risk of threatened abortion (OR 1,76, CI 0,90-3,47), preeclampsia (OR 2,77, CI 0,94-8,14), placental insufficiency (OR 2,45, CI 1,04-5,87), which has a direct effect on the formation of allergic diseases and, particularly, asthma in their children. Conclusion. Even severe asthma, is not a contraindication for pregnancy. The basic condition for the safety pregnancy and delivery is the adequate medical care that is a set of preventive and therapeutic measures for control of the disease that improve the quality of life of women during gestation and reduce the risk of allergic disease in their children.</p></abstract><trans-abstract xml:lang="ru"><p>Цель работы. Изучение особенностей течения беременности у больных бронхиальной астмой (БА) и состояния здоровья их детей. Материалы и методы. Исследовано течение беременности и родов 1010 женщин, страдающих БА, и состояние здоровья их детей до 7-летнего возраста. Больные наблюдались весь период гестации пульмонологом и акушером-гинекологом, проводилось обследование, на основании результатов которого формировался комплекс лечебно-профилактических мероприятий, давались рекомендации по первичной профилактике аллергических заболеваний у будущего ребенка. Дети с момента рождения находились под наблюдением педиатра-аллерголога. Результаты. Рост частоты встречаемости осложнений беременности у больных БА прямо зависит от отсутствия контроля заболевания, особенно в первом триместре гестации. Отсутствие адекватной терапии БА приводит к повышению риска угрозы прерывания беременности (OR 1,76, CI 0,90-3,47), гестоза (OR 2,77, Cl 0,94-8,14), плацентарной недостаточности (OR 2,45, Cl 1,04-5,87), что оказывает прямое действие на формирование аллергических заболеваний, и в частности БА, у потомства. Заключение. БА, даже тяжелые ее формы, не является противопоказанием к беременности. Основным условием благополучного вынашивания и рождения ребенка является своевременное назначение комплекса профилактических и лечебных мероприятий, направленных на достижение контроля над заболеванием, что позволяет не только улучшить качество жизни женщины во время гестации, но и снизить риск развития аллергического заболевания у ее ребенка.</p></trans-abstract><kwd-group xml:lang="en"><kwd>asthma</kwd><kwd>pregnancy</kwd><kwd>children</kwd><kwd>allergy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>бронхиальная астма</kwd><kwd>беременность</kwd><kwd>дети</kwd><kwd>аллергия</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Global Initiative for Asthma Pocket guide for asthma management and prevention (2012). Available at: www.ginasthma.org/ local/uploads/files/GINA_Pocket2013_May15.pdf.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Schatz M., Zeiger R.S. Improving asthma outcomes in large populations. J. Allergy Clin. Immunol. 2011, v. 128 (2), p. 273-277.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Jenkins M.A., Hopper J.L., Flander L.B. et al. The associations between childhood asthma and atopy, and parental asthma, hay fever and smoking. Paediatr. Perinat. Epidemiol. 1993, v. 7, p. 67-76.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Greally M., Jagoe W.S., Greally J. The genetics of asthma. Ir. Med. J. 1982, v. 75, p. 403-405.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Sibbald B. Genetics of asthma and atopy: an overview. Clin. Exp. Allergy. 1991, v. 21, p. 178-181.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Jenkins M.A., Hopper J.L., Bowes G. et al. Factors in childhood as predictors of asthma in adult life. BMJ. 1994, v. 309, p. 90-93.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Laitinen T, Rasanen M., Kaprio J. et al. Importance of genetic factors in adolescent asthma: a population-based twin-family study. Am. J. Respir. Crit. Care Med. 1998, v. 157, p. 10731078.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Cуханова Л.П. Структура и уровень перинатальной патологии в современной России. Медико-психологические аспекты современной пренатальной и перинатальной психологии, психотерапии и перинатологии. М., 2005, c. 6-8.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Schatz M., Dombrowski M.P., Wise R. et al. The relationship of asthma medication use to perinatal outcomes. J. Allergy Clin. Immunol. 2004, v. 113, p. 1040-1045.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Murphy V.E., Gibson P.G., Giles W.B. et al. Maternal asthma is associated with reduced female fetal growth. Am. J. Respir. Crit. Care Med. 2003, v. 168, p. 1317-1323.</mixed-citation></ref></ref-list></back></article>
