Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press34910.36691/RJA349ArticlesСтатьиResearch ArticleIs the level of cord blood IgE considered to be a marker of antenatal «programming» of allergic phenotype in newborn infant?Является ли уровень IgE в пуповинной крови показателем антенатального «программирования» аллергического фенотипа ребенка?EvsyukovaI IЕвсюковаИ Иeevs@yandex.ruIlchukovaO VИльчуковаО ВD.O. Ott Research Institute for Obstetrics and GynecologyФГБУ «Научно-исследовательский институт акушерства, гинекологии и репродуктологии им. Д.О. Отта»15062016133NO3 (2016)№3 (2016)111410032020Copyright ©; 2016, Pharmarus Print MediaCopyright ©; 2016, Фармарус Принт Медиа2016Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/349

The article presents the literature data and the results of own research on the allergic phenotype diagnostics and the prediction capability of IgE level in the cord blood in newborns.

В статье представлены данные литературы и результаты собственных исследований, касающиеся диагностики аллергического фенотипа новорожденного ребенка и возможности прогноза развития аллергии на основании определения в пуповинной крови уровня IgE.

IgEIgEcord bloodnewbornprevention«programming» allergic phenotypeпуповинная кровьноворожденный«программирование» аллергического фенотипаРевякина В.А. Патогенез, клинические проявления и лечение пищевой аллергии у детей. Вопр. детской диетол. 2007, № 6, с. 26-29.Балаболкин И.И. Гастроинтестинальная пищевая аллергия у детей. Педиатрия. 1997, № 1, с. 32-36.Новик Г.А. аллергия. Иммунная система. СПб., «амфора». 2013, 64 с.Abraham C.M., Ownby D.R. Ontogeny of the inflammatory response. Immunol. Allergy Clin. North. Am. 2005, v. 25, p. 215-229.Wang J., Sampson H.A. Food allergy. J. Clin. Invest. 2011, v. 121, p. 827-835.Прямкова Ю.В. Пренатальное становление бронхиальной астмы. аллергология. 2001, № 4, с. 23-29.Баранов А.А., Балаболкина И.И. Детская аллергология. Руководство для врачей. М., Группа «ГЭОТАР-Медиа». 2006, 687 с.Евсюкова И.И. Влияние неблагоприятных факторов в антенатальном и раннем постнатальном онтогенезе на развитие аллергических реакций у детей. Аллергология. 2001, № 1, с. 37-44.Moore M.M., Rifas-Shiman S.L., Rich-Edwards J.W. et al. Perinatal Predictors of Atopic Dermatitis Occurring in the First Six Months of Life. Pediatrics. 2004, v. 113, p. 468-474.Warner J.A., Jones C.A., Jones A.C., Warner J.O. Prenatal origins of allergic disease. J. Allergy Clin. Immunol. 2000, v. 105, p. 493-498.Chung E.K., Miller R.L., Wilson M.T et al. Antenatal risk factors, cytokines and the development of atopic disease in early childhood. Arch. Dis. Child. Fetal Neonatal Ed. 2007, v. 92, p. 68-73.Prescott S.L., Taylor A., Roper J. et al. Maternal reactivity to fetal alloantigens is related to newborn immune responses and subsequent allergic disease. Clin. EXP. Allergy. 2005, v. 35, p. 417-425.Bernsen R.M., van der Wouden J.C., Nagelkerke N.J. et al. Early life circumstances and atopic disorders in childhood. Clin. Exp. Allergy. 2006, v. 36, p. 858-865.Sybilski A.J., Doboszynska A., Samolinski B. Total and antigen-specific IgE levels in umbilical cord blood. Eur. J. Med. Res. 2009, v. 14, p. 233-236.Hernandez E., Barraza-Villarreal A., Escamilla-Nunez M.C. et al. Prenatal determinants of cord blood total immunoglobulin E levels in Mexican newborns. Allergy Asthma Proc. 2013, v. 34, p. 27-34.Jenmalm M.C., Bjorksten B., Macaubas C. et al. Allergen-induced cytokine secretion in relation to atopic symptoms and immunoglobulin E and immunoglobulin G subclass antibody responses. Pediatr. Allergy Immunol. 1999, v. 10, p. 168-177.Ярилин А.А. Основы иммунологии. М., Медицина. 1999, 608 с.Тотолян А.А. Иммуноглобулин Е: структура, продукция, биологические эффекты и диагностическое использование. Аллергология. 1999, № 2, c. 4-7.Prussin C., Metcalfe D.D. IgE, mast cells, basophils, and eosinophils. J. Allergy Clin. Immunol. 2006, v. 117, p. 450-456.Yamaoka A., Kuwabara I., Frigeri L.G, Liu F.T A human lectin, galectin-3 (epsilon bp/Mac-2), stimulates superoxide production by neutrophils. J. Immunol. 1995, v. 154, p. 3479-3487.Truong M.J, Gruart V., Kusnierz J.P. et al. Human neutrophils express immunoglobulin E (IgE) - binding proteins (Mac-2/ epsilon BP) of the S-type lectin family: role in IgE-dependent activation. J. Exp. Med. 1993, v. 177, p. 243-248.Jeschke U., Mayr D., Schiessl B. et al. Expression ofgalectin-1, -3 (gal-1, gal-3) and the Thomsen- Friedenreich (TF) antigen in normal, IUGR, preeclamptic and HELLP placentas. Placenta. 2007, v. 28, p. 1165-1173.Iio A., Waldmann T.A., Strober W. Metabolic study of human IgE: evidence for an extra vascular catabolic pathway. J. Immunol. 1978, v. 120, p. 1696-1701.Geha R.S, Helm B., Gould H. Inhibition of the Prausnitz-Kustner reaction by an immunoglobulin epsilon-chain fragment synthesized in E. coli. Nature. 1985, v. 315, p. 577-578.Фрейдлин И.С., Тотолян А.А. Клетки иммунной системы. СПб., Наука. 2001, № 3, 390 с.Sverremark Ekstrom E., Nilsson C., Holmlund U. et al. IgE is expressed on, but not produced by, fetal cells in the human placenta irrespective of maternal atopy. Clin. Exp. Immunol. 2002, v. 127, p. 274-282.Joerink M., Rindsjo E., Stenius F. et al. Evidence for allergen-specific IgE of maternal origin in human placenta. Allergy. 2009, v. 64, p. 905-912.Rindsjo E., Joerink M., Papadogiannakis N., Scheynius A. IgE in the human placenta: why there? Allergy. 2010, v. 65, p. 554-560.Warner J.A., Warner J.O. Early life events in allergic sensitization. British Medical Bulletin. 2000, v. 56, p. 883-893.Strimas J.H., Chi D.S. Significance of IgE level in amniotic fluid and cord blood for the prediction of allergy. Ann. Allergy. 1988, v. 61, p. 133-136.Marti E., Ehrensperger F., Burger D. et al. Maternal transfer of IgE and subsequent development of IgE responses in the horse. Veterinary Immunology and Immunopathology. 2009, v. 127, p. 203-211.Blanco Q. Synthesis and modulation of IgE in newborn infant. Allergol. Immunopathol. (Madr.) 1998, v. 26, p. 87-90.Ekstrom E.S., Bengtsson A., Svensson A. et al. Presence of CD30+ and CD30L+ cells in human placenta and soluble CD30 levels in cord blood are independent of maternal atopy. Placenta. 2000, v. 22, p. 372-379.Punnonen J., Aversa G.G., Vandekerckhove B. et al. Induction of isotype switching and Ig production by CD5+ and CD10+ human fetal B-cells. J. Immunol. 1992, v. 148, p. 3398-3404.Kamemura N., Tada H., Shimojo N. et al. Intrauterine sensitization of allergen-specific IgE analyzed by a highly sensitive new allergen microarray. J. Allergy Clin. Immunol. 2012, v. 130, p. 113-121.Pfefferie P.I., Ege M.J., Buchele G. et al. Cord blood allergen-specific IgE is associated with reduced IFN-gamma production by cord blood cells: the Protection against Allergy-Study in Rural Environments (PASTURE) Study. J. Allergy Clin. Immunol. 2008, v. 122, p. 711-716.Scirica C.V., Gold D.R., Ryan L. et al. Predictors ofcord blood IgE levels in children at risk for asthma and atopy. J. Allergy Clin. Immunol. 2007, v. 119, p. 81-88.MacGinnite A. In utero anaphylaxis. Medical Hypothesis. 2011, v. 76, p. 70-72.Peters J.L., Suglia S.F., Platts-Mills T.A.E. et al. Relationships among Prenatal Aeroallergen Exposure, Maternal and Cord Blood Immunoglobulin E: Project ACCESS. J. Allergy Clin. Immunol. 2009, v. 123, p. 1041-1046.Herberth G., Hinz D., Roder S. et al. Maternal immune status in pregnancy is related to offspring’s immune responses and atopy risk. Allergy. 2011, v. 66, p. 1065-1074.Bonnelykke K., Pipper C. B., Bisgaard H. Sensitization does not development in utero. J. Allergy Clin. Immunol. 2008, v. 121, p. 646-651.Bertino E., Bisson C., Martano C. et al. Relationship between maternal- and fetal-specific IgE. Pediatr Allergy Immunol. 2006, v. 17, p. 484-488.Bonnelykke K., Pipper C.B., Bisgaard H. Transfer of maternal IgE can be common cause of increased IgE levels in cord blood. J. Allergy Clin. Immunol. 2010, v. 126, p. 657-663.Peters J.L., Cohen S., Staudenmayer J. et al. Prenatal negative life events increases cord blood IgE: interactions with dust mite allergen and maternal atopy. Allergy. 2012, v. 67, p. 545-551.Herr C.E., Ghosh R., Dostal M. et al. Exposure to air pollution in critical prenatal time windows and IgE levels in newborns. Pediatr. Allergy Immunol. 2011, v. 22, p. 75-84.Oryszczyn M.P., Annesi-Maesano I., Campagna D. et al. Head circumference at birth and maternal factors related to cord blood total IgE. Clin. Exp. Allergy. 1999, v. 29, p. 334-341.Reichrtova E., Ciznar P., Prachar V. et al. Cord serum immunoglobulin E related to the environmental contamination of human placentas with organochlorine compounds. Environ Health Perspect. 1999, v. 107, p. 895-899.Song F., Zhou X.S., Wang T et al. IgE level of cord blood in neonates with meconium-stained amniotic fluid. Zhongguo Dang Dai Er Ke Za Zhi. 2007, v. 9, p. 361-363.Xiong F., Tong Y., Li P. et al. Serum immunoglobulin E level and its impact on the pregnancy outcome associated with fetal growth restriction: a prospective cohort stuffy. Genetics Mol. Res. 2015, v. 14, p. 3879-3888.Yu Z., Chen J., Zhang Q. et al. Maternofetal transfer of antibodies and the influence of maternal atopic status on the neonate. Am. J. Rhinol. Allergy. 2015, v. 29, p. 119-123.Michel FB., Bousquet J., Greiller P. et al. Comparison of cord blood immunoglobulin E concentrations and maternal allergy for the prediction of atopic diseases in infancy. J. Allergy. 1980, v. 65, p. 422-430.Halken S. Prevention of allergic disease in childhood: clinical and epidemiological aspects of primary and secondary allergy prevention. Paediatr. Allergy Immunol. 2004, v. 15, p. 4-32.Prokesova L., Novotna O., Janatkova I. et al. IgE against food and respiratory allergens in healthy and allergic mothers and their children. Folia Microbiol (Praha). 2008, v. 53, p. 67-72.Shah P.S., Wegienka G., Havstad S. et al. The relationship between cord blood immunoglobulin E levels and allergy-related outcomes in young adults. Ann. Allergy Asthma Immunol. 2011, v. 106, p. 245-251.Nabavi M., Ghorbani R., Asadi A.M., Faranoush M. Factors associated with cord blood IgE levels Asian Pac. J. Allergy Immunol. 2013, v. 31, p. 157-182.Wen H.J., Wang Y.J., Lin Y.J. et al. Prediction of atopic dermatitis in 2-yr-old children by cord blood IgE, genetic polymorphisms in cytokine genes, and maternal mentality during pregnancy. Pediatr. Allergy Immunol. 2011, v. 22, p. 695-703.Bergmann R.L., Edenharter G., Bergmann K.E. et al. Predictability of early atopy by cord blood- IgE and parenteral history. Clin. Exp. Allergy. 1997, v. 27, p. 752-760.Ильчукова О.В. Формирование предрасположенности к аллергии при хронической плацентарной недостаточности. Автореферат дисс. канд. мед. наук. СПб., 2016, 26 с.Евсюкова И.И., Ильчукова О.В., Зубжицкая Л.Б. Механизмы программирования ранней пищевой сенсибилизации при развитии в условиях хронической плацентарной недостаточности. Вопр. практич. педиатрии. 2011, № 4, с. 17-21.Shang W.T., Sun H.L., Lue K.H., Chou M.C. Predictability of early onset atopic dermatitis by cord blood IgE and parental history. Acta Paediatr. Taiwan. 2005, v. 46, p. 272-277.Nissen S.P., Kjaer H.F., Host A. et al. Can family history and cord blood IgE predict sensitization and allergic diseases up to adulthood? Ped. Allergy Immunol. 2015, v. 28, p. 42-48.Смирнов И.Е. Механизмы формирования аллергических реакций. В кн.: Детская аллергология. Руководство для врачей. Под ред. А.А. Баранова и И.И. Балаболкина. М., «ГЭОТАР-Медиа». 2006, с. 32-104.