Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press34710.36691/RJA347ArticlesСтатьиResearch ArticleTHE STUDY OF BALANCE OF Th1/Th2 IMMUNE RESPONSE DURING VIRUS-INDUCED ASTHMA EXACERBATIONИЗУЧЕНИЕ БАЛАНСА TH1/TH2-ИММУННОГО ОТВЕТА ПРИ ВИРУС-ИНДУЦИРОВАННЫХ ОСЛОЖНЕНИЯХ БРОНХИАЛЬНОЙ АСТМЫGaisinaA RГайсинаАлина Рашидовна

Institute of Immunology

ar.gaysina@nrcii.ruShilovskiyI PШкловскийИ П

Institute of Immunology

NikonovaA AНиконоваА А

Institute of Immunology Mechnikov Research Institute for Vaccines and Sera

SundukovaM SСундуковаМ С

Institute of Immunology

ZaretskaiaM AЗарецкаяМ А

Institute of Immunology

SmirnovV VСмирновВ В

Institute of Immunology First Moscow state medical university named after I.M. Sechenov

KamishnikovO YКамышниковО Ю

Institute of Immunology

IvanovaA SИвановаА С

Institute of Immunology

KhaitovM RХаитовМ Р

Institute of Immunology

ФГБУ «ГНЦ Институт иммунологии» ФМБА РоссииФГБНУ НИИВС им. И.И. МечниковаПервый Московский государственный медицинский университет им. И.М. СеченоваФГБУ «ГНЦ Институт иммунологии» ФМБА России15102016134-5NO4-5 (2016)№4-5 (2016)202810032020Copyright ©; 2016, Pharmarus Print MediaCopyright ©; 2016, Фармарус Принт Медиа2016Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/347

Bronchial asthma (BA) is the most common chronic disease of the airways affecting up to 18% of population in different regions of the world. Respiratory viruses such as rhinoviruses and respiratory syncytial virus (RSV) are the main causes of BA exacerbations. Current data demonstrate the major role of Th1- and Th2-response and corresponding cytokines in the development of infectious and allergic inflammation of the airways. At the same time, there are no data available concerning changes in Th1/Th2-balance during virus-induced asthma exacerbations. In the current study, we evaluated Th1/Th2-balance using developed mouse model of RSV-induced BA exacerbation. In was demonstrated, that RSV infection does not increase Th2-immune response but enhances Th1-response that shifts Th1/Th2-balance towards Th1.

Бронхиальная астма (БА) - одно из самых распространенных хронических заболеваний дыхательных путей. Заболеваемость БА достигает 18% в разных регионах мира. Респираторные вирусы, такие как рино-вирусы и респираторно-синцитиальный вирус (РСВ), являются основной причиной осложнений БА. На сегодняшний день продемонстрирована важная роль Th1- и Тh2-иммунного ответа и соответствующих цитокинов в развитии инфекционного и аллергического воспаления дыхательных путей. В то же время недостаточно данных об изменениях Тh1/Тh2-баланса при вирус-индуцированных обострениях БА. В настоящем исследовании была разработана на мышах экспериментальная модель РСВ-индуцированных осложнений БА, которая была использована для изучения баланса Тh1/Тh2-иммунного ответа при развитии данной патологии. В результате проведенных исследований было показано, что РСВ-инфекция на фоне сенсибилизации к аллергену не вызывает усиления Тh2-имунного ответа, но усиливает Тh1-ответ, что в итоге сдвигает общий Тh1/Тh2-баланс в сторону Th1.

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