Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press34610.36691/RJA346ArticlesСтатьиReview ArticleTransepithelial initiation of allergic responseТрансэпителиальный запуск аллергического ответаGushchinI SГущинИгорь Сергеевичigushchin@yandex.ruInstitute of ImmunologyФГБУ «ГНЦ Институт иммунологии» ФМБА России15062016133NO3 (2016)№3 (2016)31010032020Copyright ©; 2016, Pharmarus Print MediaCopyright ©; 2016, Фармарус Принт Медиа2016Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/346

The paper is focused on structure and functions of airway epithelial barrier and allergen-mediated innate immune response of the epithelium leading to facilitation of allergy development.

Статья посвящена структуре и функции эпителиального барьера воздухоносных путей и врожденному иммунному ответу эпителия на аллергены, приводящему к облегчению формирования аллергии.

airway epithelial barrierallergensinnate immune responseГущин И.С. Об элементах биологической целесообразности аллергической реактивности. Пат. физиол. 1979, № 4, с. 3-11.Гущин И.С. Аллергенная проницаемость барьерных тканей - стратегическая проблема аллергологии. Пульмонология. 2006, № 3, с. 5-10.Гущин И.С. Эволюционное предупреждение: аллергия. Пат. физиол. 2014, № 1, с. 27-67.Гущин И.С. Эпидермальный барьер и аллергия. Рос. Аллергол. Журн. 2007, № 2, с. 3-16.Ganesan S., Comstock A.T., Sajjan U.S. Barrier function of airway tract epithelium. Tissue Barriers. 2013, v. 1, p. e24997-1 - e24997-9 (http://dx.doi.org/10.4161/tisb.24997).Sidhaye V.K., Schweitzer K.S., Caterina M.J. et al. Shear stress regulates aquaporin-5 and airway epithelial barrier function. Proc. Natl. Acad. Sci. USA. 2008, v. 105, p. 3345-3350.Vermeer P.D., Einwalter L.A., Moninger T.O. et al. Segregation of receptor and ligand regulates activation of epithelial growth factor receptor. Nature. 2003, v. 422, p. 322-326.Humlicek AQ.L., Manzel L.J., Chin C.L. et al. Paracellular permeability restricts airway epithelial responses to selectively allow activation by mediators at the basolateral surface. J. Immunol. 2007, v. 178, p. 6395-6403.McCarthy K.M., Francis S.A., McCormack J.M. et al. Inducible expression of claudin-1-mic but not occluding-VSV-G results in aberrant tight junction strand formation in MDCK cells. J. Cell. Sci. 2000, v. 113, p. 3387-3398.Benais-Pont G., Punn A., Flores-Maldonado C. et al. Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability. J. Cell. Biol. 2003, v. 160, p. 7129-740.Гущин И.С. Преодоление аллергенами тканевого барьера - решающая форма предрасположения к аллергии. Пат. физиол. 2009, № 1, с. 8-13.Zeitlin P.L. Cystic fibrosis and estrogens: a perfect storm. J. Clin. Invest. 2008, v. 118, p. 3841-3844.Maeda Y., Chen G., Xu Y et al. Airway epithelial transcription factor NK2 homeobox 1 inhibits mucous cell metaplasia and Th2 inflammation. Am. J. Respir. Crit. Care Med. 2011, v. 184, p. 421-429.Noone P.G., Leigh M.W., Sannuti A. et al. Primary ciliary dyskinesia: diagnostic and phenotypic features. Am. J. Respir. Crit. Care Med. 2004, v. 169, p. 459-467.Tamashiro E., Xiong G., Anselmo-Lima WT. et al. Cigarette smoke exposure impairs respiratory epithelial ciliogenesis. Am. J. Rhinol. Allergy. 2009, v. 23, p. 117-122.Pavia D., Bateman J.R.M., Sheahan N.F. et al. Tracheobronchial mucociliary clearance in asthma: impairment during remission. Thorax. 1985, v. 40, p. 171-175.Wanner A., Salante M., O’Riordan T. Mucociliary clearance in the airway: state of art. Am. J. Respir. Crit. Care Med. 1996, v. 154, p. 1868-1902.Bennet W.D., Herbst M., Alexis N.E. et al. Effect of inhaled dust mite allergen on regional partical deposition and mucociliary clearance in allergic asthmatics. Clin. Exp. Allergy. 2011, v. 41, p. 1719-1728.Holgate S.T. Mechanisms of asthma and implications for its prevention and treatment: a personal journey. Allergy Asthma Immunol. Res. 2013, v. 5, p. 343-347.Gonzalez-Mariscal L., Batanzos A., Avila-Flores A. MAGUK proteins: structure and role in the tight junction. Semin. Cell. Dev. Biol. 2000, v. 11, p. 315-324.Kojima T., Go M., Takano K.-I. et al. Regulation of tight junctions in upper airway epithelium. BioMed Research International. 2013, Article ID 947072, 11 pages. (http://dx.doi. org/10.1155/2013/947072).Rezaee F., Georas S.N. Breaking barriers. New insight into airway epithelial barrier function in health and disease. Am. J. Respir. Cell Mol. Biol. 2014, v. 50, p. 857-869.Xiao C., Puddicombe S.M., Field S. et al. Defective epithelial barrier function in asthma. J. Allergy Clin. Immunol. 2011, v. 128, p. 549-556.Vinhas R., Cortes L., Cardoso I. et al. Pollen proteases compromise the airway epithelial barrier through degradation of transmembrane adhesion proteins and lung bioactive peptides. Allergy. 2011, v. 66, p. 1088-1098.Wan H., Winton H.L., Soeller C. et al. Der p 1 facilitates transepithelial allergen delivery by disruption of tight junctions. J. Clin. Invest. 1999, v. 104, p. 123-133.Gandhi V.D., Vliagoftis H. Airway epithelium interactions with aeroallergens: role of secreted cytokines and chemokines in innate immunity. Frontiers in Immunology. 2015, v. 6, article 147. doi: 10.3389/fimmu.2015.00147. eCollection 2015.Leino M.S., Loxham M., Blume C. et al. Barrier disrupting effects of Alternaria alternata extract on bronchial epithelium from asthmatic donors. PLoS One, 2013, v. 18, e71278, doi: 10.1371/journal.pone.0071278.Sha Q., Truong-Tran H.Q., Plitt J.R. et al. Activation of airway epithelial cells by toll-like receptor agonists. Am. J. Respir. Cell. Mol. Biol. 2004, v. 31, p. 359-364.Asokananthan N., Graham P.T., Fink J. et al. Activation of proteinase-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial calls. J. Immunol. 2002, v. 168, p. 3577-3585.Nathan A.T., Peterson E.A., Chakir J. et al. Innate immune responses of airway epithelium to house dust mite are mediated through beta-glucan-dependent pathways. J. Allergy Clin. Immunol. 2009, v. 123, p. 612-618.Ryu J.H., Yoo J.Y, Kim M.J., Hwang S.G. et al. Distinct TLR-mediated pathways regulate house dust mite-induced allergic disease in the upper and lower airways. J. Allergy Clin. Immunol. 2013, v. 131, p. 549-561.Chiou Y.L., Lin C.Y. Der p 2 activates airway smooth muscle cells in a TLR-2/MyD88-dependent manner to induce an inflammatory response. J. Cell. Physiol. 2009, v. 220, p. 311-318.Trompette A., Divanovic S., Visintin A. et al. Allergenicity resulting from functional mimicry of Toll-like receptor complex protein. Nature. 2009, v. 457, p. 585-588.Гущин И.С., Курбачева О.М. Аллергия и аллергенспецифическая иммунотерапия. М., «Фармарус Принт Медиа», 2010, с. 68-73.