Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press33710.36691/RJA337ArticlesСтатьиResearch ArticleA case report of combination of asthma and allergic rhinitis caused by local household sensitization with a brief analysis of literatureСочетание бронхиальной астмы и аллергического ринита, вызванных локальной бытовой сенсибилизацией. Описание случая с кратким анализом литературыPrylutskyiA SПрилуцкийА Сaspr@mail.ruPrylutskayaI AПрилуцкаяИ АRohovaYu DРоговаяЮ ДLesnichenkoD AЛесниченкоД АDonetsk National Medical University named after GorkyДонецкий национальный медицинский университет им. М. Горького15022017141NO1 (2017)№1 (2017)475310032020Copyright ©; 2017, Pharmarus Print MediaCopyright ©; 2017, Фармарус Принт Медиа2017Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/337

Currently diagnosis of allergic diseases is based largely on results of skin tests and laboratory methods of quantification of total and specific immunoglobulins E in serum in addition to clinical and instrumental data. However, in recent years it has been showed that systemic atopy is not always registered with these methods and specific immunoglobulins E may not have diagnostic concentrations in serum that makes it difficult to diagnose allergic diseases. The article presents a clinical case of combination of asthma and allergic rhinitis caused by local IgE production with normal level of serum I-4, reduced levels of IgG1, IgG2 and serum and secretory IgA in child aged 3 years.

В настоящий момент диагностика аллергических заболеваний помимо клинико-инструментальных данных во многом основывается на результатах кожных проб и лабораторных методов количественного определения в сыворотке крови общего и аллерген-специфических иммуноглобулинов Е. Однако в последние годы показано, что системная атопия регистрируется при этом далеко не всегда, а аллерген-специфические иммуноглобулины E могут не иметь диагностических значений в сыворотке крови, что затрудняет диагностику заболеваний аллергической этиологии. В статье представлен клинический случай сочетания бронхиальной астмы и аллергического ринита у ребенка в возрасте 3 лет, вызванных локальной продукцией IgE при нормальном уровне IL-4 в сыворотке крови, снижении IgG1, IgG2 и сывороточного и секреторного IgA.

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