Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press32010.36691/RJA320ArticlesСтатьиReview ArticleProspects for studying of FOXP3 and its isoforms expression in allergic diseasesПерспективы изучения экспрессии молекулы FOXP3 и ее изоформ при аллергических заболеванияхSmirnovD SСмирновДмитрий Сергеевичfreeeezy@mail.ruKurbachevaO MКурбачеваО МPolnerS AПольнерС АPavlovaK SПавловаК СInstitute of ImmunologyФГБУ «ГНЦ Институт иммунологии» ФМБА России15042017142VOL 14, NO2 (2017)ТОМ 14, №2 (2017)222910032020Copyright ©; 2017, Pharmarus Print MediaCopyright ©; 2017, Фармарус Принт Медиа2017Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/320

In this review we describe FOXP3 (a specific marker of regulatory T-cells), nature of FOXP3 isoforms (with or without exon 2) expression and cooperation with other transcription factors under various immunopathological conditions and discuss the prospects for studying of FOXP3 isoforms expression in CD4+ T-cells in allergic diseases.

Обзор посвящен транскрипционному фактору FOXP3, специфическому маркеру регуляторных Т-лимфоцитов, и его кооперации с другими транскрипционными факторами, особенностям экспрессии изоформ молекулы FOXP3, содержащих продукт экзона 2 и лишенных его, при различных иммунопатологических состояниях, перспективам изучения экспрессии изоформ молекулы FOXP3 CD4+ Т-клетками при аллергических заболеваниях.

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