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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="review-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">319</article-id><article-id pub-id-type="doi">10.36691/RJA319</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Review Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">Clinical contraindications to allergen immunotherapy</article-title><trans-title-group xml:lang="ru"><trans-title>Клинические противопоказания к АСИТ</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Kurbacheva</surname><given-names>O M</given-names></name><name xml:lang="ru"><surname>Курбачева</surname><given-names>Оксана Михайловна</given-names></name></name-alternatives><email>kurbacheva@gmail.com</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Pavlova</surname><given-names>K S</given-names></name><name xml:lang="ru"><surname>Павлова</surname><given-names>К С</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Galitskaya</surname><given-names>M A</given-names></name><name xml:lang="ru"><surname>Галицкая</surname><given-names>М А</given-names></name></name-alternatives><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">Institute of Immunology</institution></aff><aff><institution xml:lang="ru">ФГБУ «ГНЦ Институт иммунологии» ФМБА России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-04-15" publication-format="electronic"><day>15</day><month>04</month><year>2017</year></pub-date><volume>14</volume><issue>2</issue><issue-title xml:lang="en">VOL 14, NO2 (2017)</issue-title><issue-title xml:lang="ru">ТОМ 14, №2 (2017)</issue-title><fpage>10</fpage><lpage>21</lpage><history><date date-type="received" iso-8601-date="2020-03-10"><day>10</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Pharmarus Print Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, Фармарус Принт Медиа</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Pharmarus Print Media</copyright-holder><copyright-holder xml:lang="ru">Фармарус Принт Медиа</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2019-12-15"/></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/319">https://rusalljournal.ru/raj/article/view/319</self-uri><abstract xml:lang="en"><p>It presents an analysis of international position papers, federal clinical recommendations and national publications focused on contraindications to allergen immunotherapy (AIT) in recent years. In details absolute and relative clinical contraindications to allergen immunotherapy (AIT) are described.</p></abstract><trans-abstract xml:lang="ru"><p>Представлен анализ международных позиционных документов, Федеральных клинических рекомендаций и отечественных публикаций освещающих противопоказания к применению аллерген-специфической иммунотерапии (АСИТ) за последние годы. Подробно описаны абсолютные и относительные клинические противопоказания применения АСИТ.</p></trans-abstract><kwd-group xml:lang="en"><kwd>allergen immunotherapy (AIT)</kwd><kwd>subcutaneous immunotherapy (SCIT)</kwd><kwd>sublingual immunotherapy (SLIT)</kwd><kwd>venom immunotherapy (VIT)</kwd><kwd>absolute and relative clinic contraindications</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>аллерген-специфическая иммунотерапия (АСИТ)</kwd><kwd>подкожная иммунотерапия (ПКИТ)</kwd><kwd>сублингвальная иммунотерапия (СЛИТ)</kwd><kwd>иммунотерапия ядами перепончатокрылых насекомых (ИТЯ)</kwd><kwd>абсолютные и относительные клинические противопоказания к АСИТ</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>http://ec.europa.eu/health/files/eudralex/vol2/c/smpc_ guideline_rev2_en.pdf (assessed 2 April 2015).</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Pesek R.D., Lockey R.F. Treatment of Hymenoptera venom allergy: an update. Curr. Opin. Allergy Clin. Immunol. 2014, v. 14, p. 340-346.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Cox L., Nelson H., Lockey R. et al. Allergen immunotherapy: a practice parameter third update. J. Allergy Clin. Immunol. 2011, v. 127, p. 1-55.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Alvarez-Cuesta E., Bousquet J., Canonica G.W et al. EAACI, Immunotherapy Task Force. Standards for practical allergen-specific immunotherapy. J. Allergy. 2006, v. 61, p. 1-20.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Krishna M.T., Ewan P.W., Diwakar L. et al. Diagnosis and management of hymenoptera venom allergy: British Society for Allergy and Clinical Immunology (BSACI) guidelines. Clin. Exp. Allergy. 2011, v. 41, p. 1201-1220.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Shekelle P.G., Woolf S.H., Eccles M. et al. J. Clinical guidelines: developing guidelines. BMJ. 1999, v. 318, p. 593-596.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Bousquet J., Lockey R.F., Malling H.J. WHO, Position Paper. Allergen immunotherapy: therapeutic vaccines for allergic diseases. J. Allergy. 1998, v. 53, p. 1-42.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Wesley B.A., Calderon M.A., Casale T et al. Update on allergy immunotherapy: American Academy of Allergy, Asthma &amp; Immunology / European Academy of Allergy and Clinical Immunology / PRACTALL consensus report. J. Allergy Clin. Immunol. 2013, v. 131, p. 1288-1296.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Abramson M.J., Puy R.M., Weiner J.M. Injection allergen immunotherapy for asthma. Cochrane Database Syst Rev. 2010, v. 8, CD001186.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Penagos M., Passalacqua G., Compalati E. et al. Meta-analysis of the efficacy of sublingual immunotherapy in the treatment of allergic asthma in pediatric patients, 3 to 18 years of age. J. Chest. 2008, v. 133, p. 599-609.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Compalati E., Braido F., Canonica G.W An update on allergen immunotherapy and asthma. Curr. Opin. Pulm. Med. 2014, v. 20, p. 109-117.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Papadopoulos N.G., Arakawa H., Carlsen K.H. et al. International consensus on (ICON) pediatric asthma. J. Allergy. 2012, v. 67, p. 976-997.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Calderon M.A., Cox L., Casale T.B. et al. Multiple-allergen and single- allergen immunotherapy strategies in polysensitized patients: looking at the published evidence. J. Allergy Clin. Immunol. 2012, v. 129, p. 929-934.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Bousquet J., Hejjaoui A., Dhivert H. et al. Immunotherapy with a standardized Dermatophagoides pteronyssinus extract. Systemic reactions during the rush protocol in patients suffering from asthma. J. Allergy Clin. Immunol. 1989, v. 83, p. 797-802.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Lockey R.F., Nicoara-Kasti G.L., Theodoropoulos D.S. et al. Systemic reactions and fatalities associated with allergen immunotherapy. Ann. Allergy Asthma Immunol. 2001, v. 87, p. 47-55.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Bernstein D.I., Wanner M., Borish L. et al. Twelve-year survey of fatal reactions to allergen injections and skin testing: 1990-2001. J. Allergy Clin. Immunol. 2004, v. 113, p. 1129-1136.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Schiappoli M., Ridolo E., Senna G. et al. A prospective Italian survey on the safety of subcutaneous immunotherapy for respiratory allergy. Clin. Exp. Allergy. 2009, v. 39, p. 1569-1574.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Update CSM. Desensitising vaccines. Br. Med. J. 1986, v. 293, p. 948.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Bousquet J., Mantzouranis E., Cruz A.A. et al. Uniform definition of asthma severity, control, and exacerbations: document presented for the World Health Organization Consultation on severe asthma. J. Allergy Clin. Immunol. 2010, v. 126, p. 926-938.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Nielsen L., Johnsen C., Mosbech H. et al. Antihistamine premedication in specific cluster immunotherapy: a double-blind, placebo-controlled study. J. Allergy Clin. Immunol. 1996, v. 97, p. 1207-1213.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Massanari M., Nelson H., Casale T. et al. Effect of pretreatment with omalizumab on the tolerability of specific immunotherapy in allergic asthma. J. Allergy Clin. Immunol. 2010, v. 125, p. 383-389.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Garcia-Robaina J.C., Sanchez I., de la Torre F. et al. Successful management of mite-allergic asthma with modified extracts of Dermatophagoides pteronyssinus and Dermatophagoides farina in a double-blind, placebo-controlled study. J. Allergy Clin. Immunol. 2006, v. 118, p. 1026-1032.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Walker S.M., Durham S.R., Till S.J. et al. BSACI guidelines immunotherapy for allergic rhinitis. Clin. Exp. Allergy. 2011, v. 41, p. 1177-1200.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Alvarez-Cuesta E., Beristain A. Conduite pratique de l’immu-noth_erapie. Practical management of immunotherapy. Revue Française d’Allergologie et d’Immunologie Clinique. 2003, v. 43, p. 301-309.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Turkcapar N., Kinikli G., Sak S.D. et al. Specific immunotherapy-induced Sjogren’s syndrome. Rheumatol Int. 2005, v. 26, p. 182-184.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Nakajima H., Ohtsuka S., Nishina T. et al. Multiple sclerosis after allergen-specific immunotherapy and influenza vaccination. J. Eur. Neurol. 2003, v. 50, p. 248-249.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Maciel B.M., Morfin B.M. Specific immunotherapy - related scleroderma. Case report. Rev. Allerg. Mex. 2009, v. 56, p.135-144.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>Quirce S., Fernandez R.M., Losada E. et al. Recurrent pericarditis: a rare complication of allergen immunotherapy. J. Allergy. 1992, v. 47, p. 343-345.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Taylor R.J. Hypersensitivity vasculitis occurring in a patient receiving immunotherapy. J. Allergy Clin. Immunol. 1991, v. 87, p. 889-890.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Berbis P., Carena M.C., Auffranc J.C. et al. Cutaneo-systemic necrotizing vasculitis occurring during desensitization. J. Ann. Dermatol. Venereol. 1986, v. 113, p. 805-810.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Ghoreschi K., Fischer J., Biedermann T Manifestation of rheumatoid arthritis during subcutaneous allergen-specific immunotherapy with bee venom. J. Allergy Clin. Immunol. 2012, v. 130, p. 1438-1439.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Perricone C., Colafrancesco S., Mazor R.D. et al. Autoimmune/inflammatory syndrome induced by adjuvants (ASIA) 2013: unveiling the pathogenic, clinical and diagnostic aspects. J. Autoimmun. 2013, v. 47, p. 1-16.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Branco-Ferreira M., Clode M.H., Palma-Carlos A.G. Distal digital vasculitis induced by specific immunotherapy. J. Allergy. 1998, v. 53, p. 102-103.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Cabrera G.E., Citera G., Gutierrez M. et al. Digital vasculitis following allergic desensitization treatment. J. Rheumatol. 1993, v. 20, p. 1970-1972.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Fiorillo A., Fonacier L., Diola C. Safety of allergenic immunotherapy in systemic lupus erythematosus. J. Allergy Clin. Immunol. 2006, v. 117 (2 Suppl), p. 264.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Golden D.B., Moffitt J., Nicklas R.A. et al. Stinging insect hypersensitivity: a practice parameter update. J. Allergy Clin. Immunol. 2011, v. 127, p. 852-854.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Palomares O., Yaman G., Azkur A.K. et al. Role of T-regulatory cells in immune regulation of allergic diseases. Eur. J. Immunol. 2010, v. 40, p. 1-9.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Shereff R.H., Harwell W., Lieberman P. et.al. Effect of beta adrenergic stimulation and blockade on immediate hypersensitivity skin test reactions. J. Allergy Clin. Immunol. 1973, v. 52, p. 328-333.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Hiatt W.R., Wolfel E.E., Stoll S. et al. Beta-2 adrenergic blockade evaluated with epinephrine after placebo, atenolol, and nadolol. Clin. Pharmacol. Ther. 1985, v. 37, p. 2-6.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Assem E.S., Schild H.O. Antagonism by beta-adrenoceptor blocking agents of the antianaphylactic effect of isoprenaline. Br. J. Pharmacol. 1971, v. 42, p. 620-630.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Matsumura Y., Tan E.M., Vaughan J.H. Hypersensitivity to histamine and systemic anaphylaxis in mice with pharmacologic beta adrenergic blockade: protection by nucleotides. J. Allergy Clin. Immunol. 1976, v. 58, p. 387-394.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Nisam M.R., Zbinden A., Chesrown S. et al. Distribution and pharmacological release of histamine in canine lung in vivo. J. Appl. Physiol. 1978, v. 44, p. 455-463.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Jacobs R.L., Rake G.W., Fournier D.C. et al. Potentiated anaphylaxis in patients with drug-induced beta-adrenergic blockade. J. Allergy Clin. Immunol. 1981, v. 68, p. 125-127.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Newman B.R., Schultz L.K. Epinephrineresistant anaphylaxis in a patient taking propranolol hydrochloride. Ann. Allergy. 1981, v. 47, p. 35-37.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Kivity S., Yarchovsky J. Relapsing anaphylaxis to bee sting in a patient treated with beta-blocker and Ca blocker. J. Allergy Clin. Immunol. 1990, v. 85, p. 669-670.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Toogood J.H. Beta-blocker therapy and the risk of anaphylaxis. CMAJ. 1987, v. 137, p. 587-588.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Cleaveland C.R., Rangno R.E., Shand D.G. A standardized isoproterenol sensitivity test. The effects of sinus arrhythmia, atropine, and propranolol. Arch. Intern. Med. 1972, v. 130, p. 47-52.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Lang D.M. Anaphylactoid and anaphylactic reactions. Hazards of beta-blockers. Drug Saf. 1995, v. 12, p. 299-304.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Lee S., Hess E.P., Nestler D.M. et al. Antihypertensive medication use is associated with increased organ system involvement and hospitalization in emergency department patients with anaphylaxis. J. Allergy Clin. Immunol. 2013, v. 131, p. 1103-1108.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Sasvary T., Muller U. Fatalities from insect stings in Switzerland 1978 to 1987. Schweiz Med. Wochenschr. 1994, v. 124, p. 1887-1894.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Bonifazi F., Jutel M., Bilo B.M. et al. Prevention and treatment of hymenoptera venom allergy: guidelines for clinical practice. J. Allergy. 2005, v. 60, p. 1459-1470.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Tunon-de-Lara J.M., Villanueva P., Marcos M. et al. ACE inhibitors and anaphylactoid reactions during venom immunotherapy. J. Lancet. 1992, v. 340, p. 908.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Ober A.I., MacLean J.A., Hannaway P.J. Lifethreatening anaphylaxis to venom immunotherapy in a patient taking an angiotensin-converting enzyme inhibitor. J. Allergy Clin. Immunol. 2003, v. 112, p. 1008-1009.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Hermann K., Ring J. The renin angiotensin system and hymenoptera venom anaphylaxis. Clin. Exp. Allergy. 1993, v. 23, p. 762-769.</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Hermann K., von Tschirschnitz M., Ebner von Eschenbach C. et al. Histamine, tryptase, norepinephrine, angiotensinogen, angiotensin-converting enzyme, angiotensin I and II in plasma of patients with hymenoptera venom anaphylaxis. Int. Arch Allergy Immunol. 1994, v. 104, p. 379-384.</mixed-citation></ref><ref id="B56"><label>56.</label><mixed-citation>Hermann K., Ring J. The renin-angiotensin system in patients with repeated anaphylactic reactions during hymenoptera venom hyposensitization and sting challenge. Int. Arch Allergy Immunol. 1997, v. 112, p. 251-256.</mixed-citation></ref><ref id="B57"><label>57.</label><mixed-citation>Rueff F., Przybilla B., Bilo M.B. et al. Predictors of side effects during the buildup phase of venom immunotherapy for Hymenoptera venom allergy: the importance of baseline serum tryptase. J. Allergy Clin. Immunol. 2010, v. 126, p. 105-115.</mixed-citation></ref><ref id="B58"><label>58.</label><mixed-citation>Stoevesandt J., Hain J., Stolze I. et al. Angiotensin-converting enzyme inhibitors do not impair the safety of Hymenoptera venom immunotherapy build-up phase. Clin. Exp. Allergy. 2014, v. 44, p. 747-755.</mixed-citation></ref><ref id="B59"><label>59.</label><mixed-citation>Rueff F., Vos B., Elberink J.O. et al. Predictors of clinical effectiveness of Hymenoptera venom immunotherapy. J. Clin. Exp. Allergy. 2014, v. 44, p. 736-746.</mixed-citation></ref><ref id="B60"><label>60.</label><mixed-citation>Livingston M.G., Livingston H.M. Monoamine oxidase inhibitors. An update on drug interactions. J. Drug Saf. 1996, v. 14, p. 219-227.</mixed-citation></ref><ref id="B61"><label>61.</label><mixed-citation>Dawson J.K., Earnshaw S.M., Graham C.S. Dangerous monoamine oxidase inhibitor interactions are still occurring in the 1990s. J. Accid. Emerg. Med. 1995, v. 12, p. 49-51.</mixed-citation></ref><ref id="B62"><label>62.</label><mixed-citation>Linneberg A., Jacobsen R.K., Jespersen L. et al. Association of subcutaneous allergen-specific immunotherapy with incidence of autoimmune disease, ischemic heart disease, and mortality. J. Allergy Clin. Immunol. 2012, v. 129, p. 413-419.</mixed-citation></ref><ref id="B63"><label>63.</label><mixed-citation>Moriset M., Moneret-Vautrin D.A., Guenard L. et al. Oral desensitization in children with milk and egg allergies obtains recovery in a significant proportion of cases. A randomized study in 60 children with cow’s milk allergy and 90 children with egg allergy. Eur. Ann. Allergy Clin. Immunol. 2007, v. 39, p. 12-19.</mixed-citation></ref><ref id="B64"><label>64.</label><mixed-citation>Staden U., Rolink-Werning Haus C., Brewer F. et al. Specific oral tolerance induction in food allergy in children: efficacy and clinical pattern of reaction. J. Allergy. 2007, v. 62, p. 1261-1269.</mixed-citation></ref><ref id="B65"><label>65.</label><mixed-citation>Barbi E., Longo G., Berti I. et al. Adverse effects during specific oral induction: in hospital «rush» phase. Eur. Ann. Allergy Clin. Immunol. 2012, v. 44, p. 18-25.</mixed-citation></ref><ref id="B66"><label>66.</label><mixed-citation>Penagos M., Compalati E., Tarantini F. et al. Efficacy of sublingual immunotherapy in the treatment of allergic rhinitis in pediatric patients 3 to 18 years of age: a metaanalysis of randomized, placebo-controlled, double-blind trials. Ann. Allergy Asthma Immunol. 2006, v. 97, p. 141-148.</mixed-citation></ref><ref id="B67"><label>67.</label><mixed-citation>Rodriguez-Santos O. Sublingual immunotherapy in allergic rhinitis and asthma in 2-5-year-old children sensitized to mites. Rev. Allerg. Mex. 2008, v. 55, p. 71-75.</mixed-citation></ref><ref id="B68"><label>68.</label><mixed-citation>Rienzo V.D., Minelli M., Musarra A. et al. Post-marketing survey on the safety of sublingual immunotherapy in children below the age of 5 years. Clin. Exp. Allergy. 2005, v. 35, p. 560-564.</mixed-citation></ref><ref id="B69"><label>69.</label><mixed-citation>Agostinis F., Tellarini L., Canonica G.W et al. Safety of sublingual immunotherapy with a monomeric allergoid in very young children. J. Allergy. 2005, v. 60, p. 133-134.</mixed-citation></ref><ref id="B70"><label>70.</label><mixed-citation>Fiocchi A., Pajno G., La Grutta S. et al. Safety of sublingual-swallow immunotherapy in children aged 3 to 7 years. Ann. Allergy Asthma Immunol. 2005, v. 95, p. 254-258.</mixed-citation></ref><ref id="B71"><label>71.</label><mixed-citation>Martinez-Canavate A., Tabar A.I., Eseverri J.L. et al. An epidemiological survey of hymenoptera venom allergy in the Spanish paediatric population. J. Allergol. Immunopathol. (Madr.). 2010, v. 38, p. 259-262.</mixed-citation></ref><ref id="B72"><label>72.</label><mixed-citation>Valentine M.D., Schuberth K.C., Kagey-Sobotka A. et al. The value of immunotherapy with venom in children with allergy to insect stings. N. Engl. J. Med. 1990, v. 323, p. 1601-1603.</mixed-citation></ref><ref id="B73"><label>73.</label><mixed-citation>Webster W.S., Freeman J.A.D. Prescription drugs and pregnancy. Expert Opin. Pharmacother. 2003, v. 4, p. 949-961.</mixed-citation></ref><ref id="B74"><label>74.</label><mixed-citation>Simons F.E., Schatz M.J. Anaphylaxis during pregnancy. J. Allergy Clin. Immunol. 2012, v. 130, p. 597-606.</mixed-citation></ref><ref id="B75"><label>75.</label><mixed-citation>Helbling A., Muller U.R., Hausmann O. Uterine contractions are known side effects of venom immunotherapy. J. Investig. Allergol Clin. Immunol. 2011, v. 21, p. 330.</mixed-citation></ref><ref id="B76"><label>76.</label><mixed-citation>Cadavid A.P., Bannenberg G.L., Arck P.C. et al. Prevention and treatment of allergic asthma in pregnancy: from conventional drugs to new therapeutical approaches. Curr. Pharm. Biotechnol. 2011, v. 12, p. 758-764.</mixed-citation></ref><ref id="B77"><label>77.</label><mixed-citation>Gani F., Braida A., Lombardi C. et al. Rhinitis in pregnancy. Eur. Ann. Allergy Clin. Immunol. 2003, v. 35, p. 306-313.</mixed-citation></ref><ref id="B78"><label>78.</label><mixed-citation>Demoly P., Piette V., Daures J.P. Treatment of allergic rhinitis during pregnancy. J. Drugs. 2003, v. 16, p. 1813-1820.</mixed-citation></ref><ref id="B79"><label>79.</label><mixed-citation>Schwartz H.J., Golden D.B., Lockey R.F. Venom immunotherapy in the Hymenoptera- allergic pregnant patient. J. Allergy Clin. Immunol. 1990, v. 85, p. 709-712.</mixed-citation></ref><ref id="B80"><label>80.</label><mixed-citation>Shaikh W.A., Shaikh S.W A prospective study on the safety of sublingual immunotherapy in pregnancy. J. Allergy. 2012, v. 67, p. 741-743.</mixed-citation></ref><ref id="B81"><label>81.</label><mixed-citation>Metzger W.J., Turner E., Patterson R. The safety of immunotherapy during pregnancy. J. Allergy Clin. Immunol. 1978, v. 61, p. 268-272.</mixed-citation></ref><ref id="B82"><label>82.</label><mixed-citation>Shaikh W.A. A retrospective study on the safety of immunotherapy in pregnancy. Clin. Exp. Allergy. 1993, v. 23, p. 857-860.</mixed-citation></ref><ref id="B83"><label>83.</label><mixed-citation>Marshal G.D. Jr. Allergen immunotherapy in HIV-infected patients. Immunol. Allergy Clin. North Am. 1997, v. 2, p. 303-317.</mixed-citation></ref><ref id="B84"><label>84.</label><mixed-citation>Marshal G.D. Jr. AIDS, HIV-positive patients, and allergies. Allergy Asthma Proc. 1999, v. 20, p. 301-304.</mixed-citation></ref><ref id="B85"><label>85.</label><mixed-citation>From the Centers for Disease Control and Prevention. 1993. Revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. JAMA. 1993, v. 269, p. 729-730.</mixed-citation></ref><ref id="B86"><label>86.</label><mixed-citation>Marcoval J., Moreno A., Mana Titel J. Subcutaneous sarcoidosis localized to sites of previous desensitizing injections. Clin. Exp. Dermatol. 2007, v. 33, p. 132-134.</mixed-citation></ref><ref id="B87"><label>87.</label><mixed-citation>Schulze J., Rose M., Zielen S. Beekeepers anaphylaxis: successful immunotherapy covered by omalizumab. J. Allergy. 2007, v. 62, p. 963-964.</mixed-citation></ref><ref id="B88"><label>88.</label><mixed-citation>Kontou-Fili K., Filis C.I. Prolonged high dose omalizumab is required to control reactions to venom immunotherapy in mastocytosis. J. Allergy. 2009, v. 64, p. 1384-1385.</mixed-citation></ref><ref id="B89"><label>89.</label><mixed-citation>Casale T.B., Busse W.W., Kline J.N. et al. Omalizumab pretreatment decreases acute reactions after rush immunotherapy for ragweed-induced seasonal allergic rhinitis. J. Allergy Clin. Immunol. 2006, v. 117, p. 134-140.</mixed-citation></ref></ref-list></back></article>
