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<article xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xmlns:ali="http://www.niso.org/schemas/ali/1.0/" article-type="research-article" dtd-version="1.2" xml:lang="en"><front><journal-meta><journal-id journal-id-type="publisher-id">Russian Journal of Allergy</journal-id><journal-title-group><journal-title xml:lang="en">Russian Journal of Allergy</journal-title><trans-title-group xml:lang="ru"><trans-title>Российский Аллергологический Журнал</trans-title></trans-title-group></journal-title-group><issn publication-format="print">1810-8830</issn><issn publication-format="electronic">2686-682X</issn><publisher><publisher-name xml:lang="en">Publishing House ABV Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="publisher-id">300</article-id><article-id pub-id-type="doi">10.36691/RJA300</article-id><article-categories><subj-group subj-group-type="toc-heading" xml:lang="en"><subject>Articles</subject></subj-group><subj-group subj-group-type="toc-heading" xml:lang="ru"><subject>Статьи</subject></subj-group><subj-group subj-group-type="article-type"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title xml:lang="en">EBASTINE. A REASONABLE CHOICE</article-title><trans-title-group xml:lang="ru"><trans-title>ЭБАСТИН. ОБОСНОВАННЫЙ ВЫБОР</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Gushchin</surname><given-names>I S</given-names></name><name xml:lang="ru"><surname>Гущин</surname><given-names>Игорь Сергеевич</given-names></name></name-alternatives><bio xml:lang="ru"><p>зав. отделом, член-корреспондент РАН, профессор, доктор медицинских наук.</p></bio><email>igushchin@yandex.ru</email><xref ref-type="aff" rid="aff1"/></contrib><contrib contrib-type="author"><name-alternatives><name xml:lang="en"><surname>Danilicheva</surname><given-names>I V</given-names></name><name xml:lang="ru"><surname>Данилычева</surname><given-names>Инна Владимировна</given-names></name></name-alternatives><bio xml:lang="ru"><p>ведущий научный сотрудник, кандидат медицинских наук.</p></bio><xref ref-type="aff" rid="aff1"/></contrib></contrib-group><aff-alternatives id="aff1"><aff><institution xml:lang="en">NRC Institute of Immunology FMBA of Russia</institution></aff><aff><institution xml:lang="ru">ФГБУ «ГНЦ Институт иммунологии» ФМБА России</institution></aff></aff-alternatives><pub-date date-type="pub" iso-8601-date="2017-10-15" publication-format="electronic"><day>15</day><month>10</month><year>2017</year></pub-date><volume>14</volume><issue>4-5</issue><issue-title xml:lang="en">VOL 14, NO4-5 (2017)</issue-title><issue-title xml:lang="ru">ТОМ 14, №4-5 (2017)</issue-title><fpage>89</fpage><lpage>97</lpage><history><date date-type="received" iso-8601-date="2020-03-10"><day>10</day><month>03</month><year>2020</year></date></history><permissions><copyright-statement xml:lang="en">Copyright ©; 2017, Pharmarus Print Media</copyright-statement><copyright-statement xml:lang="ru">Copyright ©; 2017, Фармарус Принт Медиа</copyright-statement><copyright-year>2017</copyright-year><copyright-holder xml:lang="en">Pharmarus Print Media</copyright-holder><copyright-holder xml:lang="ru">Фармарус Принт Медиа</copyright-holder><ali:free_to_read xmlns:ali="http://www.niso.org/schemas/ali/1.0/" start_date="2019-12-15"/></permissions><self-uri xlink:href="https://rusalljournal.ru/raj/article/view/300">https://rusalljournal.ru/raj/article/view/300</self-uri><abstract xml:lang="en"><p>Data on pharmacokinetics and pharmacodynamics, efficacy and safety of ebastin, a review of clinical studies of therapy of allergic rhinitis, chronic idiopathic urticaria and other dermatoses are presented.</p></abstract><trans-abstract xml:lang="ru"><p>Представлены данные о фармакокинетике и фармакодинамике, эффективности и безопасности эбастина, обзор клинических исследований терапии аллергического ринита, хронической идиопатической крапивницы и других дерматозов.</p></trans-abstract><kwd-group xml:lang="en"><kwd>ebastine</kwd><kwd>carebastine</kwd><kwd>pharmacokinetics</kwd><kwd>pharmacodynamics</kwd><kwd>allergic rhinitis</kwd><kwd>chronic idiopathic urticaria</kwd><kwd>efficacy and safety of therapy</kwd></kwd-group><kwd-group xml:lang="ru"><kwd>эбастин</kwd><kwd>каребастин</kwd><kwd>фармакокинетика</kwd><kwd>аллергический ринит</kwd><kwd>хроническая идиопатическая крапивница</kwd><kwd>эффективность и безопасность терапии</kwd></kwd-group></article-meta></front><body></body><back><ref-list><ref id="B1"><label>1.</label><mixed-citation>Rico S, Antonijoan RM, Barbanoj MJ. Ebastine in the light of CONGA recommendations for the development of third-generation antihistamines Journal of Asthma and Allergy. 2009;2:73-92.</mixed-citation></ref><ref id="B2"><label>2.</label><mixed-citation>Гущин ИС. Аллергическое воспаление и его фармакологический контроль. М.; «Фармарус Принт», 1998. 252 с.</mixed-citation></ref><ref id="B3"><label>3.</label><mixed-citation>Liu KH, Kim MG, Lee D, Yoon YJ, Kim MJ, Shon JH et al. Characterization of ebastine, hydroxyebastine, and carebastine metabolism by human liver microsomes and expressed cytochrome P450 enzymes: major roles for CYP2J2 and CYP3A. Drug Metabolism and Disposition. 2006;34:1793-1797.</mixed-citation></ref><ref id="B4"><label>4.</label><mixed-citation>Гущин ИС. Обратные агонисты Н1-рецепторов как перспективные противоаллергические средства (обзор). Химикофармацевтический журнал. 2010:(1):8388.</mixed-citation></ref><ref id="B5"><label>5.</label><mixed-citation>Wiseman LR, Faulds D. Ebastine. A review of its pharmacological properties and clinical efficacy in the treatment of allergic disorders. Drugs. 1996;51:260-277.</mixed-citation></ref><ref id="B6"><label>6.</label><mixed-citation>Simons FER, Simons KJ. Clinical pharmacolody of new antihistamine H1-receptor antagonists. Clin. Pharmacokinet. 1999;36:329-3521.</mixed-citation></ref><ref id="B7"><label>7.</label><mixed-citation>Hurst M, Spencer CM. Ebastine: an update ofits use in allergic disorders. Drugs. 2000;59:981-1006.</mixed-citation></ref><ref id="B8"><label>8.</label><mixed-citation>Pentikis HS, Huyang My Dorr MB, Heald DL. The effect of food on bioavailability of ebastine. Am. J. Ther. 1997;4:80-84.</mixed-citation></ref><ref id="B9"><label>9.</label><mixed-citation>Pasko P, Rodacki T, Domagala-Rodacka R, Palimonka K, Marcinkowska M, Owczarek D. Second generation H1-antihistamines interaction with food and alcohol-A systematic review. Biomedicine &amp; Pharmacotherapy. 2017;93:27-39.</mixed-citation></ref><ref id="B10"><label>10.</label><mixed-citation>Yamaguchi T, Hashizume T, Matsuda M, Sakashita M, Fujii T, Sekine Y et al. Pharmacokinetics of the H1-receptor antagonist ebastine and its active metabolite carebastine in healthy subjects. Arzneimittelforschung. 1994;44:59-64.</mixed-citation></ref><ref id="B11"><label>11.</label><mixed-citation>Frank H Jr, Gillen M, Rohatagi SS, Lim J, George G. Ebastine Study Group. A double-blind placebo-controlled study of the efficacy and safety of ebastine 20 mg once daily given with and without food in the treatment of seasonal allergic rhinitis. J. Clin. Pharmacol. 2002;42:1097-1104.</mixed-citation></ref><ref id="B12"><label>12.</label><mixed-citation>Van Cauwenberge P, De Belder T, Sys L. A review of the second-generation antihistamine ebastine for the treatment of allergic disorders. Expert Opin. Pharmacother. 2004;5: 1807-1813.</mixed-citation></ref><ref id="B13"><label>13.</label><mixed-citation>Lasseter KC, Dilzer SC, Vargas R, Waldman S, Noveck RJ. Pharmacokinetics and safety of ebastine in patients with impaired hepatic function compared with healthy volunteers: a phase I open-label study. Clin. Pharmacokinet. 2004;43:121-129.</mixed-citation></ref><ref id="B14"><label>14.</label><mixed-citation>Noveck RJ, Preston RA, Swan SK. Pharmacokinetics and safety of ebastine in healthy subjects and patients with renal impairment. Clin. Pharmacokinet. 2007;46:525-534.</mixed-citation></ref><ref id="B15"><label>15.</label><mixed-citation>Torrent J, Barbanoj MJ, Lzquierdo L, Segura J, Jané F. Ebastine pharmacokinetics and antihistamine effect in man. Rev Pharmacol Clin Exp. 1988;5:181.</mixed-citation></ref><ref id="B16"><label>16.</label><mixed-citation>Vincent J, Liminana R, Meredith PA, Reid JL. The pharmacokinetics, antihistamine and concentration effect relationship of ebastine in healthy subjects. Br J Clin Pharmac. 1988;26:497-501.</mixed-citation></ref><ref id="B17"><label>17.</label><mixed-citation>Frossard N, Benabdesselam O, Purohit A, Mounedji N, Pauli G. Activity of ebastine (10 and 20 mg) and cetirizine at 24 hours of a steady state treatment in the skin of healthy volunteers. Fundam Clin Pharmacol. 2000;14:409-413.</mixed-citation></ref><ref id="B18"><label>18.</label><mixed-citation>Antonijoan R, Garcia-Gea C, Puntes M, Perez J, Esbri R, Serra C, Fortea J, Barbanoj MJ. Comparison of inhibition of cutaneous histamine reaction of ebastine fast-dissolving tablet (20 mg) versus desloratadine capsule (5 mg): a randomized, double-blind, double-dummy, placebo-controlled, three-period crossover study in healthy, nonatopic adults. Clin Ther. 2007;29:814-822.</mixed-citation></ref><ref id="B19"><label>19.</label><mixed-citation>Campbell A, Michel FB, Bremard-Oury C, Crampette L, Bousquet J. Overview of allergic mechanisms. Ebastine has more than an antihistamine effect. Drugs. 1996;52:15-19.</mixed-citation></ref><ref id="B20"><label>20.</label><mixed-citation>Nori M, Iwata S, Munakata Y et al. Ebastine inhibits T-cell migration, production of Th2-type cytokines and proinflammatory cytokines. Clin Exp Allergy. 2003;33:1544-1554.</mixed-citation></ref><ref id="B21"><label>21.</label><mixed-citation>Horiguchi T, Tachikawa S, Kasahara J, Shiga M, Kondo R, Miyazaki H. Effect of ebastine on serum eosinophil cationic protein levels in patients with bronchial asthma. Clin Drug Invest. 1999;17:435-440.</mixed-citation></ref><ref id="B22"><label>22.</label><mixed-citation>Ratner P, Hampel F Jr, Gispert J. Efficacy of ebastine in the control of nasal congestion associated with allergic rhinitis. Methods Find Exp Clin Pharmacol. 2003;25:111-115.</mixed-citation></ref><ref id="B23"><label>23.</label><mixed-citation>Ciprandi G, Cirillo I, Mora F, La Rosa M. Ebastine improves nasal symptoms and airflow and affects response to decongestion test in patients with persistent allergic rhinitis: a pilot study. Allergy Asthma Proc. 2007;28:578-581.</mixed-citation></ref><ref id="B24"><label>24.</label><mixed-citation>Storms WW. Clinical studies of the efficacy and tolerability of ebastine 10 or 20 mg once daily in the treatment of seasonal allergic rhinitis in the US. Drugs. 1996;52:20-25.</mixed-citation></ref><ref id="B25"><label>25.</label><mixed-citation>Ratner PH, Lim JC, Georges GC. Comparison of once-daily ebastine 20 mg, ebastine 10 mg, loratadine 10 mg, and placebo in the treatment of seasonal allergic rhinitis. The Ebastine Study Group. J Allergy Clin Immunol. 2000;105:1101-1107.</mixed-citation></ref><ref id="B26"><label>26.</label><mixed-citation>Bousquet J, Gaudano EM, Palma Carlos AG, Staudinger H. A 12-week, placebo-controlled study of the efficacy and safety of ebastine, 10 and 20 mg once daily, in the treatment of perennial allergic rhinitis. Multicentre Study Group. Allergy. 1999;54:562-568.</mixed-citation></ref><ref id="B27"><label>27.</label><mixed-citation>Picado Valles C, Cadahia Garcia A, Cistero Bahima A, Cano Cantudo L, Sanz Amaro A, Zayas Sanza JM. Ebastine in perennial allergic rhinitis. Ann Allergy. 1991;67:615-618.</mixed-citation></ref><ref id="B28"><label>28.</label><mixed-citation>De Molina M, Cadahia Garcia A, Cano Cantudo L, Sanz Amaro A. Efficacy and tolerability of ebastine at two dose levels in the treatment of seasonal allergic rhinitis. Drug Invest. 1989;1:40-46.</mixed-citation></ref><ref id="B29"><label>29.</label><mixed-citation>Pelaez A. Clinical efficacy of ebastine in the treatment and prevention of seasonal allergic rhinitis. Drugs. 1996;52:35-38.</mixed-citation></ref><ref id="B30"><label>30.</label><mixed-citation>Gehanno P, Bremard-Oury C, Zeisser P Comparison of ebastine to cetirizine in seasonal allergic rhinitis in adults. Ann Allergy Asthma Immunol. 1996;76:507-512.</mixed-citation></ref><ref id="B31"><label>31.</label><mixed-citation>Hampel F Jr, Howland W, 3rd, Van Bavel J, Ratner P A randomized, double-blind, placebo-controlled study comparing the efficacy and safety of ebastine (20 mg and 10 mg) to loratadine 10 mg once daily in the treatment of seasonal allergic rhinitis. J Investig Allergol Clin Immunol. 2004;14:56-63.</mixed-citation></ref><ref id="B32"><label>32.</label><mixed-citation>Davies RJ. Efficacy and tolerability comparison of ebastine 10 and 20 mg with loratadine 10 mg: a double-blind, randomised study in patients with perennial allergic rhinitis. Clin Drug Investig. 1998;16:413-420.</mixed-citation></ref><ref id="B33"><label>33.</label><mixed-citation>Sastre J. Ebastine in allergic rhinitis and chronic idiopathic urticaria. Allergy. 2008; 89:1-20.</mixed-citation></ref><ref id="B34"><label>34.</label><mixed-citation>Ciprandi G. Clinical utility and patient adherence with ebastine for allergic rhinitis.Patient Prefer Adherence. 2010;4: 389-395.</mixed-citation></ref><ref id="B35"><label>35.</label><mixed-citation>Peyri J, Vidal J, Marron J, Fonseca E, Suarez E, Ledo A. Ebastine in chronic urticaria: a double-blind placebo-controlled study. J Dermatolog Treat. 1991;2:51-53.</mixed-citation></ref><ref id="B36"><label>36.</label><mixed-citation>Kalis B. Double-blind multicentre comparative study of ebastine, terfenadine and placebo in the treatment of chronic idiopathic urticaria in adults. Drugs. 1996;52:30-33.</mixed-citation></ref><ref id="B37"><label>37.</label><mixed-citation>Magerl M, Schmolke J, Siebenhaar F, Zuberbier T, Metz M, Maurer M. Acquired cold urticaria symptoms can be safely prevented by ebastine. Allergy. 2007;62:1465-1468.</mixed-citation></ref><ref id="B38"><label>38.</label><mixed-citation>Goyal V, Gupta A, Gupta O, Lal D, Gill M. Comparative Efficacy and Safety of Ebastine 20 mg, Ebastine 10 mg and Levocetirizine 5 mg in Acute Urticaria. J Clin Diagn Res. 2017;11:6-9.</mixed-citation></ref><ref id="B39"><label>39.</label><mixed-citation>Godse KV. Ebastine in chronic spontaneous urticaria in higher doses. Indian J Dermatol. 2011;56:597-598.</mixed-citation></ref><ref id="B40"><label>40.</label><mixed-citation>Данилычева ИВ, Ильина НИ, Самцов АВ, Разнатовский АВ, Ващенко ЕВ. и соавт. Удвоенная доза Кестина 20 в лечении хронической крапивницы: результаты многоцентрового российского исследования эффективности и безопасности. Вестник дерматологии и венерологии. 2007;(5):6365.</mixed-citation></ref><ref id="B41"><label>41.</label><mixed-citation>Pecoraro L, Paiola G, Pietrobelli A. Ebastine overdose in a child, Clinical Case Reports, 2017;5:403-405.</mixed-citation></ref><ref id="B42"><label>42.</label><mixed-citation>Сидоренко ИВ, Захаржевская ТВ, Караулов АВ. Антигистаминные препараты в лечении крапивницы. Лечащий врач. 2004;(5):313.</mixed-citation></ref><ref id="B43"><label>43.</label><mixed-citation>Елисютина ОГ, Феденко ЕС, Земская ЕН, Штырбул ОВ. Опыт клинического применения эбастина в лечении больных спонтанной крапивницей. Российский Аллергологический Журнал. 2016;(4):81-86.</mixed-citation></ref><ref id="B44"><label>44.</label><mixed-citation>Roger A, Fortea J, Artés M, Montilla L. Preferred attributes of the new fast dissolving tablet (FDT) formulation of ebastine in patients with allergy. J Outcomes Res. 2006;10:13-22.</mixed-citation></ref><ref id="B45"><label>45.</label><mixed-citation>Львов А. Кестин в терапии зудящих дерматозов. Врач. 2004;(9):5556.</mixed-citation></ref><ref id="B46"><label>46.</label><mixed-citation>Перламутров ЮН, Ольховская КБ, Ляпон АО, Айвазова ТВ. Новые возможности в фармакотерапии атопического дерматита. Вестник дерматологии и венерологии. 2017;(3):68-75.</mixed-citation></ref><ref id="B47"><label>47.</label><mixed-citation>Плиева КТ, Мельниченко ОО, Невозинская ЗА, Корсунская ИМ. Возможности контроля кожных аллергических реакций. Эффективная фармакотерапия. Дерматовенерология и дерматокосметология. 2016;(3): 36.</mixed-citation></ref><ref id="B48"><label>48.</label><mixed-citation>Цикаришвили НВ, Цискаришвили НИ. Авен50 и эбастин в лечении и профилактике фотодерматозов. Georgian medical news. 2009;(2):5256.</mixed-citation></ref><ref id="B49"><label>49.</label><mixed-citation>Moss AJ, Chaikin P, Garcia JD, Gillen M, Roberts DJ, Morganroth J. A review of the cardiac systemic side-effects of antihistamines: ebastine. Clin Exp Allergy. 1999;29:200-205.</mixed-citation></ref><ref id="B50"><label>50.</label><mixed-citation>Gillen MS, Miller B, Chaikin P, Morganroth J. Effects of supratherapeutic doses of ebastine and terfenadine on the QT interval. Br J Clin Pharmacol. 2001;52:201-204.</mixed-citation></ref><ref id="B51"><label>51.</label><mixed-citation>Chaikin P, Gillen MS, Malik M, Pentikis H, Rhodes GR, Roberts DJ. Co-administration of ketoconazole with H1-antagonists ebastine and loratadine in healthy subjects: pharmacokinetic and pharmacodynamic effects. Br J Clin Pharmacol. 2005;59:346-354.</mixed-citation></ref><ref id="B52"><label>52.</label><mixed-citation>Vincent J, Sumner DJ, Reid JL. Ebastine: the effect of a new antihistamine on psychomotor performance and autonomic responses in healthy subjects. Br J Clin Pharmac 1988;26: 503-508.</mixed-citation></ref><ref id="B53"><label>53.</label><mixed-citation>Brookhuis KA, de Vries G, de Waard D. Acute and subchronic effects of the H1-histamine receptor antagonist ebastine in 10, 20 and 30 mg doses, and triprolidine 10 mg on car driving performance. Br J Clin Pharmac 1993;36:67-70.</mixed-citation></ref><ref id="B54"><label>54.</label><mixed-citation>Ebastin. Product Monograph. 2001 Almirall Prodesfarma S.A.</mixed-citation></ref><ref id="B55"><label>55.</label><mixed-citation>Study M/09020/02 Almirall Prodesfarma. Data on file.</mixed-citation></ref></ref-list></back></article>
