Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press29010.36691/RJA290ArticlesСтатьиReview ArticleACTUAL CONCEPTION OF ALLERGEN-SPECIFIC IMMUNOTHERAPY MECHANISMS, POTENTIAL BIOMARKERS OF EFFICACY AND WAYS OF ENHANCEMENTАКТУАЛЬНЫЕ ПРЕДСТАВЛЕНИЯ О МЕХАНИЗМАХ АЛЛЕРГЕН-СПЕЦИФИЧЕСКОЙ ИММУНОТЕРАПИИ, ПОТЕНЦИАЛЬНЫХ МАРКЕРАХ ЭФФЕКТИВНОСТИ И ПУТЯХ СОВЕРШЕНСТВОВАНИЯPavlovaK SПавловаКсения Сергеевна

кандидат медицинских наук, старший научный сотрудник отделения бронхиальной астмы.

KurbachevaO MКурбачёваОксана Михайловна

зав. отделением бронхиальной астмы, профессор, доктор медицинских наук.

kurbacheva@gmail.comGalitskayaM AГалицкаяМариола Александровна

аспирант отделения бронхиальной астмы.

SmirnovD SСмирновДмитрий Сергеевич

аспирант отделения бронхиальной астмы.

NRC Institute of Immunology FMBA of RussiaФГБУ «ГНЦ Институт иммунологии» ФМБА России15102017144-5VOL 14, NO4-5 (2017)ТОМ 14, №4-5 (2017)51710032020Copyright ©; 2017, Pharmarus Print MediaCopyright ©; 2017, Фармарус Принт Медиа2017Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/290

The article analyzes international position papers on the allergen-specific immunotherapy mechanisms, discusses potential biomarkers for evaluation of ASIT efficacy, as well as the perspectives for ASIT enhancement.

В статье анализируются международные позиционные документы, посвященные механизму аллерген-специфической иммунотерапии (АСИТ), обсуждаются потенциальные биомаркеры эффективности АСИТ, а также перспективы ее развития.

allergen-specific immunotherapyASITInternational consensusICONASIT mechanismsbiomarkersASIT efficacy biomarkersallergyimmunotherapyfuture ASITallergovaccineallergic diseasesallergic rhinitisallergic conjunctivitisbronchial asthmaаллерген-специфическая иммунотерапия (АСИТ)Международный консенсусмеханизмы АСИТбиомаркерымаркеры эффективностиаллергияиммунотерапиябудущее АСИТаллерговакцинааллергические заболеванияаллергический риниталлергический конъюнктивитбронхиальная астмаAkdis M, Akdis CA. Mechanisms of allergen-specific immunotherapy. J Allergy Clin Immunol. 2007;(119):780-791. DOI: 10.1016/j.jaci.2007.01.022.Akdis M. Healthy immune response to allergens: T-regulatory cells and more. Curr Opin Immunol. 2006;(18):738-744. DOI: 10.1016/j.coi.2006.06.003.Larche M, Akdis CA, Valenta R. Immunological mechanisms of allergen-specific immunotherapy. Nat Rev Immunol. 2006;(6):761-771. DOI: 10.1038/nri1934.Durham SR, Walker SM, Varga EV, Jacobson MR, O’Brien F, Noble W et al. 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