Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press28410.36691/RJA284ArticlesСтатьиResearch ArticleACTUALIZED INFORMATION ON THE USE OF LEVOCETIRIZINE IN URTICARIAАКТУАЛИЗИРОВАННАЯ ИНФОРМАЦИЯ ПО ПРИМЕНЕНИЮ ЛЕВОЦЕТИРИЗИНА ПРИ КРАПИВНИЦЕAstafievaN GАстафьеваНаталья Григорьевна

доктор медицинских наук, профессор, зав. кафедрой клинической иммунологии и аллергологии

astang@mail.ruKobzevD YКобзевД Ю

профессор, директор бизнес-образования, школа здравоохранения и социальных наук.

GamovaI VГамоваИ В

кандидат медицинских наук, доцент кафедры клинической иммунологии и аллергологии.

PerfilovaI AПерфиловаИ А

кандидат медицинских наук, ассистент кафедры клинической иммунологии и аллергологии.

UdovichenkoE NУдовиченкоЕ Н

кандидат медицинских наук, ассистент кафедры клинической иммунологии и аллергологии.

MikhaylovaI EМихайловаИ Э

кандидат медицинских наук, ассистент кафедры клинической иммунологии и аллергологии.

SkuchaevaL VСкучаеваЛ В

ассистент кафедры клинической иммунологии и аллергологии

Federal state budgetary educational institution of higher professional education «Saratov state medical University named after V.I. Razumovsky» Ministry of health of the Russian FederationФГБОУ ВО «Саратовский государственный медицинский университет им. В.И. Разумовского» Минздрава РоссииLeeds Trinity UniversityЛидс Тринити университет14122017146NO6 (2017)№6 (2017)698210032020Copyright ©; 2017, Pharmarus Print MediaCopyright ©; 2017, Фармарус Принт Медиа2017Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/284

Urticaria is a widespread disease with various phenotypes, duration and severity of the course, a pronounced effect on the quality of life. Despite the heterogeneity of the disease, a huge variety of provoking triggers, the activation of mast cells is still considered the key link in pathogenesis, and therefore antihistamines of the 2nd generation remain effective and safe drugs for treatment of urticaria. The process of improving antihistamines actively continues, one of the directions is the search for molecules based on the release of more active and safe enantiomers from already known drugs (example: levocetirizine from cetirizine). Information on levocetirizine, the efficacy and safety of which in the treatment of urticaria in both adults and children, has been demonstrated in a number of well-planned randomized controlled clinical trials, as well as in various preclinical studies, due to the accumulation of new data, the advent of generic drugs, and also a new scale for assessing the quality of clinical data in the GRADE system needs to be updated. The present review is devoted to solving this problem.

Крапивница является широко распространенным заболеванием с различными фенотипами, длительностью и тяжестью течения, выраженным влиянием на качество жизни. Несмотря на гетерогенность заболевания, огромное разнообразие провоцирующих стимулов, ключевым звеном патогенеза по-прежнему рассматривается активация тучных клеток, в связи с чем эффективными и безопасными фармпрепаратами для лечения крапивницы остаются антигистаминные препараты 2-го поколения. Совершенствование антигистаминных препаратов активно продолжается, одним из направлений является поиск молекул на основе выделения более активных и безопасных энантиомеров из уже известных препаратов (например, левоцетиризин из цетиризина). Информация по левоцетиризину, эффективность и безопасность которого при лечении крапивницы как у взрослых пациентов, так и у детей продемонстрирована в ряде хорошо спланированных рандомизированных контролируемых клинических испытаний, а также в ходе различных доклинических исследований, в связи с накоплением новых данных, появлением генерических препаратов, а также новой шкалы оценки качества клинических данных в системе GRADE нуждается в обновлении, чему и посвящен настоящий обзор.

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