Russian Journal of AllergyRussian Journal of AllergyРоссийский Аллергологический Журнал1810-88302686-682XPublishing House ABV Press28310.36691/RJA283ArticlesСтатьиResearch ArticleCLINICAL PROPERTIES OF FOOD ALLERGENSКЛИНИЧЕСКОЕ ЗНАЧЕНИЕ И СВОЙСТВА ПИЩЕВЫХ АЛЛЕРГЕНОВFedorovaO SФедороваОльга Сергеевна

доктор медицинских наук, профессор кафедры факультетской педиатрии с курсом детских болезней лечебного факультета.

olga.sergeevna.fedorova@gmail.comFedotovaM MФедотоваМарина Михайловна

кандидат медицинских наук, ассистент кафедры факультетской педиатрии с курсом детских болезней лечебного факультета.

OgorodovaL MОгородоваЛюдмила Михайловна

доктор медицинских наук, член.-корр. РАН, профессор кафедры факультетской педиатрии с курсом детских болезней лечебного факультета.

KamaltynovaE MКамалтыноваЕлена МихайловнаNagaevaT AНагаеваТатьяна Александровна

доктор медицинских наук, профессор кафедры пропедевтики детских болезней с курсами поликлинической педиатрии и инфекционных болезней детского возраста

Siberian State Medical University, Ministry of Health of the Russian FederationФГБОУ ВО «Сибирский государственный медицинский университет» Минздрава России14122017146NO6 (2017)№6 (2017)596810032020Copyright ©; 2017, Pharmarus Print MediaCopyright ©; 2017, Фармарус Принт Медиа2017Pharmarus Print MediaФармарус Принт Медиаhttps://rusalljournal.ru/raj/article/view/283

Food allergy is the problems of great interest in medical community. Usually food allergy starts in infants and it is one of the main reasons of severe allergic reactions, including death as a result of anaphylaxis. In the last two decades, the development of molecular allergology facilitated significant progress in understanding of basis of food allergy. Researches in field of molecular allergology revealed that a food source can contain several different proteins responsible for allergic reaction development. Molecular structure and stability of epitopes of allergenic proteins can lead to sensitization development and severity of clinical manifestations. The aim of the present paper is to review the latest data on molecular allergology in the field of perspective diagnostics and therapeutic approaches to food allergy.

Пищевая аллергия - актуальная проблема современности. Данная патология, манифестируя в раннем возрасте, занимает лидирующую позицию в структуре причин тяжелых форм аллергии, а также смерти в результате анафилаксии. В последние два десятилетия развитие молекулярной аллергологии обеспечило значительный прогресс в изучении фундаментальных основ пищевой аллергии. Проведенные исследования позволили установить, что в составе пищевого продукта может содержаться несколько белковых компонентов, способных приводить к развитию аллергической реакции. Установлено, что физико-химические особенности аллергенных молекул и эпитопов в значительной мере оказывают влияние на особенности формирования сенсибилизации и на выраженность клинических проявлений. Целью настоящей работы является обзор достижений молекулярной аллергологии и связанных с ними перспективных диагностических и терапевтических возможностей в области пищевой аллергии.

food allergycomponent-resolved diagnosticcross reactivityfood allergenssensitizationmolecular allergologyпищевая аллергиякомпонентная аллергодиагностикаперекрестная реактивностьпищевые аллергенысенсибилизациямолекулярная аллергологияGupta R, Holdford D, Bilaver L, Dyer A, Holl JL, Meltzer D. The Economic Impact of Childhood Food Allergy in the United States. JAMA Pediatr. 2013; 167(11): 1026-1031. DOI: 10.1001/jamapediatrics.2013.2376.EAACI food allergy and anaphylaxis guidelines: diagnosis and management of food allergy. Muraro A, Werfel T, Hoffmann-Sommergruber K et al; EAACI Food Allergy and Anaphylaxis Guidelines Group. Allergy. 2014 Aug; 69: 1008-25. DOI: 10.1111/all.12429. Epub 2014 Jun 9. PMID: 24909706.Пампура АН, Варламов ЕЕ, Конюкова НГ Пищевая аллергия у детей раннего возраста. Педиатрия. Журнал им. ГН Сперанского. 2016; 95: 3: 152-157.Sampson HA. Food allergy: Past, present and future. Allergol Int, 2016; 65: 363-369. DOI: 10.1016/j.alit.2016.08.006.Food Facts From the US Food and Drug Administration. March 2017. Available at: www.fda.gov/downloads/food/resourcesforyou/consumers/ucm220117.pdf.Aalberse R.C. Structural biology of allergens. J Allergy Clin Immunol. 2000; 106: 228-38. DOI: 10.1067/mai.2000.108434.EAACI Molecular Allergology User’s Guide. Matricardi PM, Kleine-Tebbe J, Hoffmann HJ, Valenta R, Hilger C, Hofmaier S et al. Pediatr Allergy Immunol. 2016; 23: 1-250. DOI: 10.1111/pai.12563.Boyce JA, Assa’a A, Burks AW, Jones SM, Sampson HA, Wood RA, Plaut M et al. Guidelines for the diagnosis and management of food allergy in the United States: summary ofthe NIAID-Sponsored Expert Panel Report. NIAID-sponsored Expert Panel. Nutrition. 2011 Feb; 27(2): 253-67. DOI: 10.1016/j.nut.2010.12.001.Marsh DG, Goodfriend L, King TP, Lowenstein H, Platts-Mills TA. Allergen nomenclature. Bull World Health Organ 1986; 64: 767-74.King TP, Hoffman D, Lowenstein H et al. Allergen nomenclature. WHO/IUIS Allergen Nomenclature Subcommittee. Int Arch Allergy Immunol 1994; 105: 224-33.Breiteneder H. A classification of plant food allergens. J Allergy Clin Immunol. 2004 May; 113: 821-30; quiz 831. DOI: 10.1016/j.jaci.2004.01.779.Radauer C, Nandy A, Ferreira F, Goodman RE, Larsen JN, Lidholm J et al. Update of the WHO/IUIS Allergen Nomenclature Database based on analysis of allergen sequences. Allergy, 2014: 69: 413-419.Hauser M, Roulias A, Ferreira F, Egger M. Panallergens and their impact on the allergic patient. Allergy Asthma Clin Immunol. 2010; 18: 67-78. DOI: 10.1186/1710-1492-6-1.Ferreira F, Hawranek T, Gruber P, Wopfner N, Mari A. Allergic cross-reactivity: from gene to the clinic. Allergy. 2004; 59: 243-67. DOI: 10.1046/j.1398-9995.2003.00407.x.Mondoulet L, Paty E, Drumare MF, Ah-Leung S, Scheinmann P, Willemot RM, Wal JM, Bernard H. Influence of thermal processing on the allergenicity of peanut proteins. J Agric Food Chem. 2005; 53: 4547-53. DOI: 10.1021/jf050091p.Burks AW, Tang M, Sicherer S, Muraro A, Eigenmann PA, Ebisawa M et al. ICON: food allergy. J Allergy Clin Immunol. 2012 Apr; 129(4): 906-20. DOI: 10.1016/j.jaci.2012.02.001.Finkelman FD. Peanut allergy and anaphylaxis. Curr Opin Immunol. 2010; 22: 783-8. DOI: 10.1016/j.coi.2010.10.005.Fiocchi A, Brozek J, Sch nemann H, Bahna SL, von Berg A, Beyer K, Bozzola M et al. World Allergy Organization (WAO) Diagnosis and Rationale for Action against Cow’s Milk Allergy (DRACMA) Guidelines. World Allergy Organ J. 2010; 3: 57-161. DOI: 10.1097/WОX.0b013e3181defeb9.Hofmann A. Pollen food syndrome: update on the allergens. Curr Allergy Asthma Rep. 2008; 8: 413-417.Han Y Korean J Food allergy. Pediatr. 2012 May; 55(5): 153-8. DOI: 10.3345/kjp.2012.55.5.153.Зайнетдинова ГМ. Перекрестные пищевые реакции у больных с пыльцевой аллергией. Практическая медицина, 2012,(63), с. 42Сергеев АВ, Мокроносова МА. Синдром оральной аллергии. Медицинская иммунология. 2011; (13): 17-28Movérare R, Westritschnig K, Svensson M, Hayek B, Bende M, Pauli G et al. Different IgE reactivity profiles in birch pollen-sensitive patients from six European populations revealed by recombinant allergens: an imprint of local sensitization. Int Arch Allergy Immunol. 2002; 128: 325-35.Огородова ЛМ, Фёдорова ОС, Федотова ММ, Евдокимова ТА. Формирование пищевой сенсибилизации у детей на фоне инвазии Opisthorchis felineus. Вестник РАМН. 2014; (1-2): 64-8Сергеев АВ. Аллергия к пищевым аллергенам растительного происхождения у больных поллинозом. А.В. Сергеев, М.А. Мокроносова. Аллергология. 2002; (1): 51-55Heine RG, Laske N, Hill DJ. The diagnosis and management of egg allergy. Curr Allergy Asthma Rep. 2006; 6: 145-152.Cooke SK, Sampson HA. Allergenic properties of ovomucoid in man. J Immunol. 1997; 159: 2026-32.Vance GH, Lewis SA, Grimshaw KE, Wood PJ, Briggs RA, Thornton CA, Warner JO. Exposure of the fetus and infant to hens’ egg ovalbumin via the placenta and breast milk in relation to maternal intake of dietary egg. Clin Exp Allergy. 2005; 35: 1318-26. DOI: 10.1111/j.1365-2222.2005.02346.x.Yamada K, Urisu A, Kakami M, Koyama H, Tokuda R, Wada E, Kondo Y, Ando H, Morita Y Torii S. IgE-binding activity to enzyme-digested ovomucoid distinguishes between patients with contact urticaria to egg with and without overt symptoms on ingestion. Allergy. 2000; 55: 565-9.Proctor VA, Cunningham FE. The chemistry of lysozyme and its use as a food preservative and a pharmaceutical. Crit Rev Food Sci Nutr. 1988; 26: 359-95. DOI: 10.1080/10408398809527473.Quirce S, Maranôn F, Umpiérrez A, de las Heras M, Fernández-Caldas E, Sastre J. Chicken serum albumin (Gal d 5*) is a partially heat-labile inhalant and food allergen implicated in the bird-egg syndrome. Allergy. 2001; 56: 754-62.Kattan JD, Sicherer SH. Optimizing the Diagnosis of Food allergy Immunol Allergy Clin North Am. 2015 Feb; 35: 61-76. DOI: 10.1016/j.iac.2014.09.009.Lara-Villoslada F, Olivares M, Xaus J. The balance between caseins and whey proteins in cow’s milk determines its al-lergenicity. J Dairy Sci. 2005; 88: 1654-60. DOI: 10.3168/jds.S0022-0302(05)72837-X.Monaci L, Tregoat V, van Hengel AJ, Anklam E. Milk allergens, their characteristics and their detection in food: A review. Eur. Food Res. Tech. 2006; 223: 149-179.Swaisgood HE. Review and update of casein chemistry. J Dairy Sci. 1993; 76: 3054-58. DOI: 10.3168/jds.S0022-0302(93)77645-661.Chatchatee P, Järvinen KM, Bardina L, Beyer K, Sampson HA. Identification of IgE- and IgG-binding epitopes on alpha(s1)-casein: differences in patients with persistent and transient cow’s milk allergy. J Allergy Clin Immunol. 2001; 107: 379-83. DOI: 10.1067/mai.2001.112372.Ehn BM, Ekstrand B, Bengtsson U, Ahlstedt S. Modification of IgE-binding during heat processing of the cow’s milk allergen beta-lactoglobulin. J Agric Food Chem. 2004; 52: 1398-403. DOI: 10.1021/jf0304371.Sawyer L, Holt C. The secondary structure of milk proteins and their biological function. J Dairy Sci. 1993; 76: 3062-78.Han GD, Matsuno M, Ito G, Ikeucht Y, Suzuki A. Meat allergy: investigation of potential allergenic proteins in beef. Biosci Biotechnol Biochem. 2000; 64: 1887-95. DOI: 10.1271/bbb.64.1887.Van Do T, Elsayed S, Florvaag E, Hordvik I, Endresen C. Allergy to fish parvalbumins: studies on the cross-reactivity of allergens from 9 commonly consumed fish. J Allergy Clin Immunol. 2005; 116: 1314-20. DOI: 10.1016/j.jaci.2005.07.033.Khora SS. Seafood-Associated Shellfish Allergy: A Comprehensive Review. Immunol Invest. 2016; 45: 504-30. DOI: 10.1080/08820139.2016.1180301.Battais F, Pineau F, Popineau Y, Aparicio C, Kanny G, Guerin L et al. Food allergy to wheat: identification of immunogloglin E and immunoglobulin G-binding proteins with sequential extracts and purified proteins from wheat flour. Clinical and Experimental Allergy. 2003; 33: 962-970.Ito K, Futamura M, Borres MP, Takaoka Y, Dahlstrom J, Sakamoto T, Tanaka A et al. IgE antibodies to ω-5 gliadin associate with immediate symptoms on oral wheat challenge in Japanese children. Allergy. 2008; 63: 1536-1542. DOI: 10.1111/j.1398-9995.2008.01753.x.Holzhauser T, Wackermann O, Ballmer-Weber BK, Bindslev-Jensen C, Scibilia J, Perono-Garoffo L et al. Soybean (Glycine max) allergy in Europe: Gly m 5 (ß-conglycinin) and Gly m 6 (glycinin) are potential diagnostic markers for severe allergic reactions to soy. Journal of Allergy and Clinical Immunology. 2009; (2): 452.e4-458.e4. DOI: 10.1016/j.jaci.2008.09.034.Ito K, Sjölander S, Sato S, Movérare R, Tanaka A, Söderström L et al. IgE to Gly m 5 and Gly m 6 is associated with severe allergic reactions to soybean in Japanese children. Journal of Allergy and Clinical Immunology. 2011; 128: 673-675. DOI: 10.1016/j.jaci.2011.04.025.Hao GD, Zheng YW, Wang ZX, Kong XA, Song ZJ, Lai XX et al. High correlation of specific IgE sensitization between birch pollen, soy and apple allergens indicates pollen-food allergy syndrome among birch pollen allergic patients in northern China. J Zhejiang Univ Sci B. 2016; 17: 399-404. DOI: 10.1631/ jzus.B1500279.De Leon MP, Rolland JM, O’Hehir RE. The peanut allergy epidemic: allergen molecular characterisation and prospects for specific therapy. Expert Rev Mol Med. 2007; 9: 1-18. DOI: 10.1017/S1462399407000208.Asarnoj A, Movérare R, Ostblom E, Poorafshar M, Lilja G, Hedlin G et al. IgE to peanut allergen components: relation to peanut symptoms and pollen sensitization. Allergy. 2010; 65: 1189-95. DOI: 10.1111/j.1398-9995.2010.02334.x.Borres MP, Maruyama N, Sato S, Ebisawa M. Recent advances in component resolved diagnosis in food allergy. Allergol Int, 2016, Aug 16. pii: S1323-8930(16)30101-0. DOI: 10.1016/j.alit.2016.07.002.Kondo Y, Urisu A. Oral Allergy Syndrome. Allergol Int. 2009; 58: 485-91. DOI: 10.2332/allergolint.09-RAI-0136.Kamath SD, Johnston EB, Iyer S, Schaeffer PM, Koplin J, Allen K, Lopata AL. IgE reactivity to shrimp allergens in infants and their cross-reactivity to house dust mite. Pediatr Allergy Immunol. 2017; 7. DOI: 10.1111/pai.12764.Costa J, Mafra I, Carrapatoso I, Oliveira MB. Hazelnut Allergens: Molecular Characterization, Detection, and Clinical Relevance. Crit Rev Food Sci Nutr. 2016; 56: 2579-2605. DOI: 10.1080/10408398.2013.826173.Wolthers OD. Component-Resolved Diagnosis in Pediatrics ISRN Pediatr. 2012: 806-920. DOI: 10.5402/2012/806920.